SCOPe 2.02: Protein: Dihydropteridin reductase (pteridine reductase)

Lineage for Protein: Dihydropteridin reductase (pteridine reductase)

Root: SCOPe 2.02
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species)

Species:

Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
- Domain for 1hdr:
  - Domain d1hdra_: 1hdr A: [29837]
    complexed with nad
Leishmania major [TaxId:5664] [63926] (10 PDB entries)
Uniprot Q01782
1. Domains for 1e7w:
  1. Domain d1e7wa_: 1e7w A: [59373]
    complexed with edo, mtx, ndp
  2. Domain d1e7wb_: 1e7w B: [59374]
    complexed with edo, mtx, ndp
2. Domains for 1e92:
  1. Domain d1e92a_: 1e92 A: [64798]
    complexed with edo, hbi, nap
  2. Domain d1e92b_: 1e92 B: [64799]
    complexed with edo, hbi, nap
  3. Domain d1e92c_: 1e92 C: [64800]
    complexed with edo, hbi, nap
  4. Domain d1e92d_: 1e92 D: [64801]
    complexed with edo, hbi, nap
3. Domains for 1w0c:
  1. Domain d1w0ca_: 1w0c A: [114052]
    complexed with nap, taq
  2. Domain d1w0cb_: 1w0c B: [114053]
    complexed with nap, taq
  3. Domain d1w0cc_: 1w0c C: [114054]
    complexed with nap, taq
  4. Domain d1w0cd_: 1w0c D: [114055]
    complexed with nap, taq
  5. Domain d1w0ce_: 1w0c E: [114056]
    complexed with nap, taq
  6. Domain d1w0cf_: 1w0c F: [114057]
    complexed with nap, taq
  7. Domain d1w0cg_: 1w0c G: [114058]
    complexed with nap, taq
  8. Domain d1w0ch_: 1w0c H: [114059]
    complexed with nap, taq
4. Domains for 2bf7:
  1. Domain d2bf7a_: 2bf7 A: [128407]
    automated match to d1e7wa_
    complexed with edo, hbi, nap
  2. Domain d2bf7b_: 2bf7 B: [128408]
    automated match to d1e7wa_
    complexed with edo, hbi, nap
  3. Domain d2bf7c_: 2bf7 C: [128409]
    automated match to d1e7wa_
    complexed with edo, hbi, nap
  4. Domain d2bf7d_: 2bf7 D: [128410]
    automated match to d1e7wa_
    complexed with edo, hbi, nap
5. Domains for 2bfa:
  1. Domain d2bfaa_: 2bfa A: [128413]
    automated match to d1e7wa_
    complexed with cb3, edo, ndp
  2. Domain d2bfab_: 2bfa B: [128414]
    automated match to d1e7wa_
    complexed with cb3, edo, ndp
  3. Domain d2bfac_: 2bfa C: [128415]
    automated match to d1e7wa_
    complexed with cb3, edo, ndp
  4. Domain d2bfad_: 2bfa D: [128416]
    automated match to d1e7wa_
    complexed with cb3, edo, ndp
6. Domains for 2bfm:
  1. Domain d2bfma_: 2bfm A: [128439]
    automated match to d1e7wa_
    complexed with ndp, top
  2. Domain d2bfmb_: 2bfm B: [128440]
    automated match to d1e7wa_
    complexed with ndp, top
  3. Domain d2bfmc_: 2bfm C: [128441]
    automated match to d1e7wa_
    complexed with ndp, top
  4. Domain d2bfmd_: 2bfm D: [128442]
    automated match to d1e7wa_
    complexed with ndp, top
7. Domains for 2bfo:
  1. Domain d2bfoa_: 2bfo A: [128444]
    automated match to d1e7wa_
    complexed with edo, ndp
  2. Domain d2bfob_: 2bfo B: [128445]
    automated match to d1e7wa_
    complexed with edo, ndp
  3. Domain d2bfoc_: 2bfo C: [128446]
    automated match to d1e7wa_
    complexed with edo, ndp
  4. Domain d2bfod_: 2bfo D: [128447]
    automated match to d1e7wa_
    complexed with edo, ndp
8. Domains for 2bfp:
  1. Domain d2bfpa_: 2bfp A: [128448]
    automated match to d1e7wa_
    complexed with edo, h4b, nap
  2. Domain d2bfpb_: 2bfp B: [128449]
    automated match to d1e7wa_
    complexed with edo, h4b, nap
  3. Domain d2bfpc_: 2bfp C: [128450]
    automated match to d1e7wa_
    complexed with edo, h4b, nap
  4. Domain d2bfpd_: 2bfp D: [128451]
    automated match to d1e7wa_
    complexed with edo, h4b, nap
9. Domains for 2qhx:
  1. Domain d2qhxa1: 2qhx A:5-288 [150796]
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
  2. Domain d2qhxb1: 2qhx B:5-288 [150797]
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
  3. Domain d2qhxc1: 2qhx C:6-288 [150798]
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
  4. Domain d2qhxd1: 2qhx D:5-288 [150799]
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
10. Domains for 3h4v:
  1. Domain d3h4va_: 3h4v A: [177181]
    automated match to d1e7wa_
    complexed with dvp, nap
  2. Domain d3h4vb_: 3h4v B: [177182]
    automated match to d1e7wa_
    complexed with dvp, nap
  3. Domain d3h4vc_: 3h4v C: [177183]
    automated match to d1e7wa_
    complexed with dvp, nap
  4. Domain d3h4vd_: 3h4v D: [177184]
    automated match to d1e7wa_
    complexed with dvp, nap
  5. Domain d3h4ve_: 3h4v E: [177185]
    automated match to d1e7wa_
    complexed with dvp, nap
  6. Domain d3h4vf_: 3h4v F: [177186]
    automated match to d1e7wa_
    complexed with dvp, nap
  7. Domain d3h4vg_: 3h4v G: [177187]
    automated match to d1e7wa_
    complexed with dvp, nap
  8. Domain d3h4vh_: 3h4v H: [177188]
    automated match to d1e7wa_
    complexed with dvp, nap
Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
- Domains for 1p33:
  1. Domain d1p33a_: 1p33 A: [93966]
    complexed with mtx, ndp
  2. Domain d1p33b_: 1p33 B: [93967]
    complexed with mtx, ndp
  3. Domain d1p33c_: 1p33 C: [93968]
    complexed with mtx, ndp
  4. Domain d1p33d_: 1p33 D: [93969]
    complexed with mtx, ndp
Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
- Domains for 1ooe:
  1. Domain d1ooea_: 1ooe A: [87196]
    structural genomics
    complexed with mes
  2. Domain d1ooeb_: 1ooe B: [87197]
    structural genomics
    complexed with mes
Norway rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
1. Domain for 1dhr:
  - Domain d1dhra_: 1dhr A: [29832]
    complexed with nad
2. Domains for 1dir:
  1. Domain d1dira_: 1dir A: [29833]
    complexed with nad
  2. Domain d1dirb_: 1dir B: [29834]
    complexed with nad
  3. Domain d1dirc_: 1dir C: [29835]
    complexed with nad
  4. Domain d1dird_: 1dir D: [29836]
    complexed with nad
Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
1. Domains for 1mxf:
  1. Domain d1mxfa_: 1mxf A: [91486]
    complexed with mtx, ndp
  2. Domain d1mxfb_: 1mxf B: [91487]
    complexed with mtx, ndp
  3. Domain d1mxfc_: 1mxf C: [91488]
    complexed with mtx, ndp
  4. Domain d1mxfd_: 1mxf D: [91489]
    complexed with mtx, ndp
2. Domains for 1mxh:
  1. Domain d1mxha_: 1mxh A: [91490]
    complexed with dhf, nap
  2. Domain d1mxhb_: 1mxh B: [91491]
    complexed with dhf, nap
  3. Domain d1mxhc_: 1mxh C: [91492]
    complexed with dhf, nap
  4. Domain d1mxhd_: 1mxh D: [91493]
    complexed with dhf, nap

More info for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases first appeared (with stable ids) in SCOP 1.55, called Protein Dihydropteridin reductase from c.2.1.2: Tyrosine-dependent oxidoreductases
Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOPe 2.01
Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOPe 2.03
Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in the current release, SCOPe 2.08