Lineage for Protein: Dihydropteridin reductase (pteridine reductase)

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 975118Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 975119Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 975436Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 975760Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species)

Species:

  1. 975761Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
  2. 975763Leishmania major [TaxId:5664] [63926] (10 PDB entries)
    Uniprot Q01782
    1. Domains for 1e7w:
      1. 975764Domain d1e7wa_: 1e7w A: [59373]
        complexed with edo, mtx, ndp
      2. 975765Domain d1e7wb_: 1e7w B: [59374]
        complexed with edo, mtx, ndp
    2. Domains for 1e92:
      1. 975766Domain d1e92a_: 1e92 A: [64798]
        complexed with edo, hbi, nap
      2. 975767Domain d1e92b_: 1e92 B: [64799]
        complexed with edo, hbi, nap
      3. 975768Domain d1e92c_: 1e92 C: [64800]
        complexed with edo, hbi, nap
      4. 975769Domain d1e92d_: 1e92 D: [64801]
        complexed with edo, hbi, nap
    3. Domains for 1w0c:
      1. 975802Domain d1w0ca_: 1w0c A: [114052]
        complexed with nap, taq
      2. 975803Domain d1w0cb_: 1w0c B: [114053]
        complexed with nap, taq
      3. 975804Domain d1w0cc_: 1w0c C: [114054]
        complexed with nap, taq
      4. 975805Domain d1w0cd_: 1w0c D: [114055]
        complexed with nap, taq
      5. 975806Domain d1w0ce_: 1w0c E: [114056]
        complexed with nap, taq
      6. 975807Domain d1w0cf_: 1w0c F: [114057]
        complexed with nap, taq
      7. 975808Domain d1w0cg_: 1w0c G: [114058]
        complexed with nap, taq
      8. 975809Domain d1w0ch_: 1w0c H: [114059]
        complexed with nap, taq
    4. Domains for 2bf7:
      1. 975774Domain d2bf7a_: 2bf7 A: [128407]
        automated match to d1e7wa_
        complexed with edo, hbi, nap
      2. 975775Domain d2bf7b_: 2bf7 B: [128408]
        automated match to d1e7wa_
        complexed with edo, hbi, nap
      3. 975776Domain d2bf7c_: 2bf7 C: [128409]
        automated match to d1e7wa_
        complexed with edo, hbi, nap
      4. 975777Domain d2bf7d_: 2bf7 D: [128410]
        automated match to d1e7wa_
        complexed with edo, hbi, nap
    5. Domains for 2bfa:
      1. 975786Domain d2bfaa_: 2bfa A: [128413]
        automated match to d1e7wa_
        complexed with cb3, edo, ndp
      2. 975787Domain d2bfab_: 2bfa B: [128414]
        automated match to d1e7wa_
        complexed with cb3, edo, ndp
      3. 975788Domain d2bfac_: 2bfa C: [128415]
        automated match to d1e7wa_
        complexed with cb3, edo, ndp
      4. 975789Domain d2bfad_: 2bfa D: [128416]
        automated match to d1e7wa_
        complexed with cb3, edo, ndp
    6. Domains for 2bfm:
      1. 975790Domain d2bfma_: 2bfm A: [128439]
        automated match to d1e7wa_
        complexed with ndp, top
      2. 975791Domain d2bfmb_: 2bfm B: [128440]
        automated match to d1e7wa_
        complexed with ndp, top
      3. 975792Domain d2bfmc_: 2bfm C: [128441]
        automated match to d1e7wa_
        complexed with ndp, top
      4. 975793Domain d2bfmd_: 2bfm D: [128442]
        automated match to d1e7wa_
        complexed with ndp, top
    7. Domains for 2bfo:
      1. 975782Domain d2bfoa_: 2bfo A: [128444]
        automated match to d1e7wa_
        complexed with edo, ndp
      2. 975783Domain d2bfob_: 2bfo B: [128445]
        automated match to d1e7wa_
        complexed with edo, ndp
      3. 975784Domain d2bfoc_: 2bfo C: [128446]
        automated match to d1e7wa_
        complexed with edo, ndp
      4. 975785Domain d2bfod_: 2bfo D: [128447]
        automated match to d1e7wa_
        complexed with edo, ndp
    8. Domains for 2bfp:
      1. 975778Domain d2bfpa_: 2bfp A: [128448]
        automated match to d1e7wa_
        complexed with edo, h4b, nap
      2. 975779Domain d2bfpb_: 2bfp B: [128449]
        automated match to d1e7wa_
        complexed with edo, h4b, nap
      3. 975780Domain d2bfpc_: 2bfp C: [128450]
        automated match to d1e7wa_
        complexed with edo, h4b, nap
      4. 975781Domain d2bfpd_: 2bfp D: [128451]
        automated match to d1e7wa_
        complexed with edo, h4b, nap
    9. Domains for 2qhx:
      1. 975770Domain d2qhxa1: 2qhx A:5-288 [150796]
        automatically matched to d1e7wa_
        complexed with fe1, iod, nap
      2. 975771Domain d2qhxb1: 2qhx B:5-288 [150797]
        automatically matched to d1e7wa_
        complexed with fe1, iod, nap
      3. 975772Domain d2qhxc1: 2qhx C:6-288 [150798]
        automatically matched to d1e7wa_
        complexed with fe1, iod, nap
      4. 975773Domain d2qhxd1: 2qhx D:5-288 [150799]
        automatically matched to d1e7wa_
        complexed with fe1, iod, nap
    10. Domains for 3h4v:
      1. 975794Domain d3h4va_: 3h4v A: [177181]
        automated match to d1e7wa_
        complexed with dvp, nap
      2. 975795Domain d3h4vb_: 3h4v B: [177182]
        automated match to d1e7wa_
        complexed with dvp, nap
      3. 975796Domain d3h4vc_: 3h4v C: [177183]
        automated match to d1e7wa_
        complexed with dvp, nap
      4. 975797Domain d3h4vd_: 3h4v D: [177184]
        automated match to d1e7wa_
        complexed with dvp, nap
      5. 975798Domain d3h4ve_: 3h4v E: [177185]
        automated match to d1e7wa_
        complexed with dvp, nap
      6. 975799Domain d3h4vf_: 3h4v F: [177186]
        automated match to d1e7wa_
        complexed with dvp, nap
      7. 975800Domain d3h4vg_: 3h4v G: [177187]
        automated match to d1e7wa_
        complexed with dvp, nap
      8. 975801Domain d3h4vh_: 3h4v H: [177188]
        automated match to d1e7wa_
        complexed with dvp, nap
  3. 975810Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
  4. 975815Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
  5. 975818Norway rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
    1. Domain for 1dhr:
    2. Domains for 1dir:
      1. 975820Domain d1dira_: 1dir A: [29833]
        complexed with nad
      2. 975821Domain d1dirb_: 1dir B: [29834]
        complexed with nad
      3. 975822Domain d1dirc_: 1dir C: [29835]
        complexed with nad
      4. 975823Domain d1dird_: 1dir D: [29836]
        complexed with nad
  6. 975824Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
    1. Domains for 1mxf:
      1. 975829Domain d1mxfa_: 1mxf A: [91486]
        complexed with mtx, ndp
      2. 975830Domain d1mxfb_: 1mxf B: [91487]
        complexed with mtx, ndp
      3. 975831Domain d1mxfc_: 1mxf C: [91488]
        complexed with mtx, ndp
      4. 975832Domain d1mxfd_: 1mxf D: [91489]
        complexed with mtx, ndp
    2. Domains for 1mxh:
      1. 975825Domain d1mxha_: 1mxh A: [91490]
        complexed with dhf, nap
      2. 975826Domain d1mxhb_: 1mxh B: [91491]
        complexed with dhf, nap
      3. 975827Domain d1mxhc_: 1mxh C: [91492]
        complexed with dhf, nap
      4. 975828Domain d1mxhd_: 1mxh D: [91493]
        complexed with dhf, nap

More info for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases: