SCOP 1.75: Protein: Dihydropteridin reductase (pteridine reductase)

Lineage for Protein: Dihydropteridin reductase (pteridine reductase)

Root: SCOP 1.75
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species)

Species:

Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
- Domain for 1hdr:
  - Domain d1hdra_: 1hdr A: [29837]
    complexed with nad
Leishmania major [TaxId:5664] [63926] (10 PDB entries)
Uniprot Q01782
1. Domains for 1e7w:
  1. Domain d1e7wa_: 1e7w A: [59373]
  2. Domain d1e7wb_: 1e7w B: [59374]
    complexed with edo, mtx, ndp
2. Domains for 1e92:
  1. Domain d1e92a_: 1e92 A: [64798]
  2. Domain d1e92b_: 1e92 B: [64799]
  3. Domain d1e92c_: 1e92 C: [64800]
  4. Domain d1e92d_: 1e92 D: [64801]
    complexed with edo, hbi, nap
3. Domains for 1w0c:
  1. Domain d1w0ca_: 1w0c A: [114052]
  2. Domain d1w0cb_: 1w0c B: [114053]
  3. Domain d1w0cc_: 1w0c C: [114054]
  4. Domain d1w0cd_: 1w0c D: [114055]
  5. Domain d1w0ce_: 1w0c E: [114056]
  6. Domain d1w0cf_: 1w0c F: [114057]
  7. Domain d1w0cg_: 1w0c G: [114058]
  8. Domain d1w0ch_: 1w0c H: [114059]
    complexed with nap, taq
4. Domains for 2bf7:
  1. Domain d2bf7a1: 2bf7 A:6-288 [128407]
    automatically matched to d1e7wa_
    complexed with edo, hbi, nap
  2. Domain d2bf7b1: 2bf7 B:6-288 [128408]
    automatically matched to d1e7wa_
    complexed with edo, hbi, nap
  3. Domain d2bf7c1: 2bf7 C:6-288 [128409]
    automatically matched to d1e7wa_
    complexed with edo, hbi, nap
  4. Domain d2bf7d1: 2bf7 D:6-288 [128410]
    automatically matched to d1e7wa_
    complexed with edo, hbi, nap
5. Domains for 2bfa:
  1. Domain d2bfaa1: 2bfa A:6-288 [128413]
    automatically matched to d1e7wa_
    complexed with cb3, edo, ndp
  2. Domain d2bfab1: 2bfa B:6-288 [128414]
    automatically matched to d1e7wa_
    complexed with cb3, edo, ndp
  3. Domain d2bfac1: 2bfa C:6-288 [128415]
    automatically matched to d1e7wa_
    complexed with cb3, edo, ndp
  4. Domain d2bfad1: 2bfa D:6-288 [128416]
    automatically matched to d1e7wa_
    complexed with cb3, edo, ndp
6. Domains for 2bfm:
  1. Domain d2bfma1: 2bfm A:6-288 [128439]
    automatically matched to d1e7wa_
    complexed with ndp, top
  2. Domain d2bfmb1: 2bfm B:6-288 [128440]
    automatically matched to d1e7wa_
    complexed with ndp, top
  3. Domain d2bfmc1: 2bfm C:6-288 [128441]
    automatically matched to d1e7wa_
    complexed with ndp, top
  4. Domain d2bfmd1: 2bfm D:6-288 [128442]
    automatically matched to d1e7wa_
    complexed with ndp, top
7. Domains for 2bfo:
  1. Domain d2bfoa1: 2bfo A:6-288 [128444]
    automatically matched to d1e7wa_
    complexed with edo, ndp
  2. Domain d2bfob1: 2bfo B:6-288 [128445]
    automatically matched to d1e7wa_
    complexed with edo, ndp
  3. Domain d2bfoc1: 2bfo C:6-288 [128446]
    automatically matched to d1e7wa_
    complexed with edo, ndp
  4. Domain d2bfod1: 2bfo D:6-288 [128447]
    automatically matched to d1e7wa_
    complexed with edo, ndp
8. Domains for 2bfp:
  1. Domain d2bfpa1: 2bfp A:6-288 [128448]
    automatically matched to d1e7wa_
    complexed with edo, h4b, nap
  2. Domain d2bfpb1: 2bfp B:6-288 [128449]
    automatically matched to d1e7wa_
    complexed with edo, h4b, nap
  3. Domain d2bfpc1: 2bfp C:6-288 [128450]
    automatically matched to d1e7wa_
    complexed with edo, h4b, nap
  4. Domain d2bfpd1: 2bfp D:6-288 [128451]
    automatically matched to d1e7wa_
    complexed with edo, h4b, nap
9. Domains for 2p8k:
  1. Domain d2p8ka1: 2p8k A:5-288 [149305]
    automatically matched to d1e7wa_
    complexed with dyp, nap
  2. Domain d2p8kb1: 2p8k B:5-288 [149306]
    automatically matched to d1e7wa_
    complexed with dyp, nap
  3. Domain d2p8kc1: 2p8k C:6-288 [149307]
    automatically matched to d1e7wa_
    complexed with dyp, nap
  4. Domain d2p8kd1: 2p8k D:5-288 [149308]
    automatically matched to d1e7wa_
    complexed with dyp, nap
  5. Domain d2p8ke1: 2p8k E:6-288 [149309]
    automatically matched to d1e7wa_
    complexed with dyp, nap
  6. Domain d2p8kf1: 2p8k F:5-288 [149310]
    automatically matched to d1e7wa_
    complexed with dyp, nap
  7. Domain d2p8kg1: 2p8k G:6-288 [149311]
    automatically matched to d1e7wa_
    complexed with dyp, nap
  8. Domain d2p8kh1: 2p8k H:5-288 [149312]
    automatically matched to d1e7wa_
    complexed with dyp, nap
10. Domains for 2qhx:
  1. Domain d2qhxa1: 2qhx A:5-288 [150796]
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
  2. Domain d2qhxb1: 2qhx B:5-288 [150797]
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
  3. Domain d2qhxc1: 2qhx C:6-288 [150798]
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
  4. Domain d2qhxd1: 2qhx D:5-288 [150799]
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
- Domains for 1p33:
  1. Domain d1p33a_: 1p33 A: [93966]
  2. Domain d1p33b_: 1p33 B: [93967]
  3. Domain d1p33c_: 1p33 C: [93968]
  4. Domain d1p33d_: 1p33 D: [93969]
    complexed with mtx, ndp
Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
- Domains for 1ooe:
  1. Domain d1ooea_: 1ooe A: [87196]
    structural genomics
  2. Domain d1ooeb_: 1ooe B: [87197]
    structural genomics
    complexed with mes
Rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
1. Domain for 1dhr:
  - Domain d1dhra_: 1dhr A: [29832]
    complexed with nad
2. Domains for 1dir:
  1. Domain d1dira_: 1dir A: [29833]
  2. Domain d1dirb_: 1dir B: [29834]
  3. Domain d1dirc_: 1dir C: [29835]
  4. Domain d1dird_: 1dir D: [29836]
    complexed with nad
Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
1. Domains for 1mxf:
  1. Domain d1mxfa_: 1mxf A: [91486]
  2. Domain d1mxfb_: 1mxf B: [91487]
  3. Domain d1mxfc_: 1mxf C: [91488]
  4. Domain d1mxfd_: 1mxf D: [91489]
    complexed with mtx, ndp
2. Domains for 1mxh:
  1. Domain d1mxha_: 1mxh A: [91490]
  2. Domain d1mxhb_: 1mxh B: [91491]
  3. Domain d1mxhc_: 1mxh C: [91492]
  4. Domain d1mxhd_: 1mxh D: [91493]
    complexed with dhf, nap

More info for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases first appeared (with stable ids) in SCOP 1.55, called Protein Dihydropteridin reductase from c.2.1.2: Tyrosine-dependent oxidoreductases
Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOP 1.73
Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOPe 2.01
Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in the current release, SCOPe 2.08