Lineage for Protein: Dihydropteridin reductase (pteridine reductase)

  1. Root: SCOP 1.71
  2. 570216Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
  3. 574151Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 574152Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 574451Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (53 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 574630Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species)

Species:

  1. 574631Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
  2. 574633Leishmania major [TaxId:5664] [63926] (3 PDB entries)
    1. Domains for 1e7w:
      1. 574634Domain d1e7wa_: 1e7w A: [59373]
      2. 574635Domain d1e7wb_: 1e7w B: [59374]
        complexed with edo, mtx, ndp
    2. Domains for 1e92:
      1. 574636Domain d1e92a_: 1e92 A: [64798]
      2. 574637Domain d1e92b_: 1e92 B: [64799]
      3. 574638Domain d1e92c_: 1e92 C: [64800]
      4. 574639Domain d1e92d_: 1e92 D: [64801]
        complexed with edo, hbi, nap
    3. Domains for 1w0c:
      1. 574640Domain d1w0ca_: 1w0c A: [114052]
      2. 574641Domain d1w0cb_: 1w0c B: [114053]
      3. 574642Domain d1w0cc_: 1w0c C: [114054]
      4. 574643Domain d1w0cd_: 1w0c D: [114055]
      5. 574644Domain d1w0ce_: 1w0c E: [114056]
      6. 574645Domain d1w0cf_: 1w0c F: [114057]
      7. 574646Domain d1w0cg_: 1w0c G: [114058]
      8. 574647Domain d1w0ch_: 1w0c H: [114059]
        complexed with nap, taq
  3. 574648Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
  4. 574653Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
  5. 574656Rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
    1. Domain for 1dhr:
    2. Domains for 1dir:
      1. 574658Domain d1dira_: 1dir A: [29833]
      2. 574659Domain d1dirb_: 1dir B: [29834]
      3. 574660Domain d1dirc_: 1dir C: [29835]
      4. 574661Domain d1dird_: 1dir D: [29836]
        complexed with nad
  6. 574662Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
    1. Domains for 1mxf:
      1. 574667Domain d1mxfa_: 1mxf A: [91486]
      2. 574668Domain d1mxfb_: 1mxf B: [91487]
      3. 574669Domain d1mxfc_: 1mxf C: [91488]
      4. 574670Domain d1mxfd_: 1mxf D: [91489]
        complexed with mtx, ndp
    2. Domains for 1mxh:
      1. 574663Domain d1mxha_: 1mxh A: [91490]
      2. 574664Domain d1mxhb_: 1mxh B: [91491]
      3. 574665Domain d1mxhc_: 1mxh C: [91492]
      4. 574666Domain d1mxhd_: 1mxh D: [91493]
        complexed with dhf, nap

More info for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases: