SCOP 1.65: Protein: Dihydropteridin reductase (pteridine reductase)

Lineage for Protein: Dihydropteridin reductase (pteridine reductase)

Root: SCOP 1.65
Class c: Alpha and beta proteins (a/b) [51349] (121 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (33 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Dihydropteridin reductase (pteridine reductase) [51769] (4 species)

Species:

Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
- Domain for 1hdr:
  - Domain d1hdr__: 1hdr - [29837]
    complexed with nad
Leishmania major [TaxId:5664] [63926] (2 PDB entries)
1. Domains for 1e7w:
  1. Domain d1e7wa_: 1e7w A: [59373]
  2. Domain d1e7wb_: 1e7w B: [59374]
    complexed with edo, mtx, ndp
2. Domains for 1e92:
  1. Domain d1e92a_: 1e92 A: [64798]
  2. Domain d1e92b_: 1e92 B: [64799]
  3. Domain d1e92c_: 1e92 C: [64800]
  4. Domain d1e92d_: 1e92 D: [64801]
    complexed with edo, hbi, nap
Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
- Domains for 1ooe:
  1. Domain d1ooea_: 1ooe A: [87196]
  2. Domain d1ooeb_: 1ooe B: [87197]
    structural genomics
    complexed with mes
Rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
1. Domain for 1dhr:
  - Domain d1dhr__: 1dhr - [29832]
    complexed with nad
2. Domains for 1dir:
  1. Domain d1dira_: 1dir A: [29833]
  2. Domain d1dirb_: 1dir B: [29834]
  3. Domain d1dirc_: 1dir C: [29835]
  4. Domain d1dird_: 1dir D: [29836]
    complexed with nad

More info for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases first appeared (with stable ids) in SCOP 1.55, called Protein Dihydropteridin reductase from c.2.1.2: Tyrosine-dependent oxidoreductases
Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOP 1.63
Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOP 1.67
Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in the current release, SCOPe 2.08