Lineage for Protein: GDP-mannose 4,6-dehydratase

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 819418Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 819419Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 819736Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 820318Protein GDP-mannose 4,6-dehydratase [51759] (4 species)

Species:

  1. 820319Escherichia coli [TaxId:562] [51760] (1 PDB entry)
  2. 820321Human (Homo sapiens) [TaxId:9606] [102135] (1 PDB entry)
  3. 820326Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)
  4. 820331Thale-cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)
    1. Domains for 1n7g:
      1. 820334Domain d1n7ga_: 1n7g A: [80246]
      2. 820335Domain d1n7gb_: 1n7g B: [80247]
      3. 820336Domain d1n7gc_: 1n7g C: [80248]
      4. 820337Domain d1n7gd_: 1n7g D: [80249]
        complexed with gdr, ndp
    2. Domains for 1n7h:
      1. 820332Domain d1n7ha_: 1n7h A: [80250]
      2. 820333Domain d1n7hb_: 1n7h B: [80251]
        complexed with gdp, ndp

More info for Protein GDP-mannose 4,6-dehydratase from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein GDP-mannose 4,6-dehydratase from c.2.1.2: Tyrosine-dependent oxidoreductases: