SCOP 1.67: Protein: GDP-mannose 4,6-dehydratase

Lineage for Protein: GDP-mannose 4,6-dehydratase

Root: SCOP 1.67
Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (11 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (40 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein GDP-mannose 4,6-dehydratase [51759] (4 species)

Species:

Escherichia coli [TaxId:562] [51760] (1 PDB entry)
- Domain for 1db3:
  - Domain d1db3a_: 1db3 A: [29813]
Human (Homo sapiens) [TaxId:9606] [102135] (1 PDB entry)
- Domains for 1t2a:
  1. Domain d1t2aa_: 1t2a A: [99078]
  2. Domain d1t2ab_: 1t2a B: [99079]
  3. Domain d1t2ac_: 1t2a C: [99080]
  4. Domain d1t2ad_: 1t2a D: [99081]
    complexed with gdp, ndp
Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)
- Domains for 1rpn:
  1. Domain d1rpna_: 1rpn A: [97708]
  2. Domain d1rpnb_: 1rpn B: [97709]
  3. Domain d1rpnc_: 1rpn C: [97710]
  4. Domain d1rpnd_: 1rpn D: [97711]
    complexed with gdp, ndp
Thale-cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)
1. Domains for 1n7g:
  1. Domain d1n7ga_: 1n7g A: [80246]
  2. Domain d1n7gb_: 1n7g B: [80247]
  3. Domain d1n7gc_: 1n7g C: [80248]
  4. Domain d1n7gd_: 1n7g D: [80249]
    complexed with gdr, ndp
2. Domains for 1n7h:
  1. Domain d1n7ha_: 1n7h A: [80250]
  2. Domain d1n7hb_: 1n7h B: [80251]
    complexed with gdp, ndp

More info for Protein GDP-mannose 4,6-dehydratase from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein GDP-mannose 4,6-dehydratase from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein GDP-mannose 4,6-dehydratase from c.2.1.2: Tyrosine-dependent oxidoreductases first appeared (with stable ids) in SCOP 1.55
Protein GDP-mannose 4,6-dehydratase from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOP 1.65
Protein GDP-mannose 4,6-dehydratase from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOP 1.69
Protein GDP-mannose 4,6-dehydratase from c.2.1.2: Tyrosine-dependent oxidoreductases appears in the current release, SCOPe 2.08