SCOP 1.75: Protein: GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase)

Lineage for Protein: GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase)

Root: SCOP 1.75
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757] (1 species)

Species:

Escherichia coli [TaxId:562] [51758] (8 PDB entries)
1. Domain for 1bsv:
  - Domain d1bsva_: 1bsv A: [29809]
    complexed with ndp
2. Domain for 1bws:
  - Domain d1bwsa_: 1bws A: [29812]
    complexed with ndp
3. Domain for 1e6u:
  - Domain d1e6ua_: 1e6u A: [29805]
    complexed with nap, so4, trs, uvw
4. Domain for 1e7q:
  - Domain d1e7qa_: 1e7q A: [29807]
    complexed with nap, so4, trs, uvw; mutant
5. Domain for 1e7r:
  - Domain d1e7ra_: 1e7r A: [29808]
    complexed with nap, so4, trs, uvw; mutant
6. Domain for 1e7s:
  - Domain d1e7sa_: 1e7s A: [29806]
    complexed with nap, so4, trs, uvw; mutant
7. Domain for 1fxs:
  - Domain d1fxsa_: 1fxs A: [29810]
    complexed with nap
8. Domain for 1gfs:
  - Domain d1gfsa_: 1gfs A: [29811]

More info for Protein GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) from c.2.1.2: Tyrosine-dependent oxidoreductases first appeared (with stable ids) in SCOP 1.55
Protein GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOP 1.73
Protein GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOPe 2.01
Protein GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in the current release, SCOPe 2.08