SCOPe 2.07: Protein: Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)

Lineage for Protein: Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)

Root: SCOPe 2.07
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (4 species)

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [141872] (1 PDB entry)
Uniprot P04397 11-357
N-terminal domain of bifunctional Gal10 protein
- Domain for 1z45:
  - Domain d1z45a2: 1z45 A:11-357 [124428]
    Other proteins in same PDB: d1z45a1
    complexed with gal, na, nad, upg
Escherichia coli [TaxId:562] [51753] (17 PDB entries)
1. Domain for 1a9y:
  - Domain d1a9ya_: 1a9y A: [29789]
    complexed with na, nad, upg; mutant
2. Domain for 1a9z:
  - Domain d1a9za_: 1a9z A: [29795]
    complexed with na, nad, pge, upg; mutant
3. Domain for 1kvq:
  - Domain d1kvqa_: 1kvq A: [29797]
    complexed with edo, na, nad, upg
4. Domain for 1kvr:
  - Domain d1kvra_: 1kvr A: [29793]
    complexed with edo, na, nad, peg, udp
5. Domain for 1kvs:
  - Domain d1kvsa_: 1kvs A: [29799]
    complexed with na, nad, peg, upg
6. Domain for 1kvt:
  - Domain d1kvta_: 1kvt A: [29798]
    complexed with na, nad, peg, upg
7. Domain for 1kvu:
  - Domain d1kvua_: 1kvu A: [29794]
    complexed with edo, na, nad, peg, upg
8. Domain for 1lrj:
  - Domain d1lrja_: 1lrj A: [74224]
    complexed with na, nad, pge, ud1
9. Domain for 1lrk:
  - Domain d1lrka_: 1lrk A: [74225]
    complexed with na, nad, pge, ud1; mutant
10. Domain for 1lrl:
  - Domain d1lrla_: 1lrl A: [74226]
    complexed with na, nad, pge, upg; mutant
11. Domain for 1nah:
  - Domain d1naha_: 1nah A: [29788]
    complexed with edo, na, nad, peg, udp
12. Domain for 1nai:
  - Domain d1naia_: 1nai A: [29796]
    complexed with na, nad, pdo, peg, udp
13. Domain for 1uda:
  - Domain d1udaa_: 1uda A: [29790]
    complexed with edo, na, nad, pge, ufg
14. Domain for 1udb:
  - Domain d1udba_: 1udb A: [29787]
    complexed with edo, na, nad, peg, ufg
15. Domain for 1udc:
  - Domain d1udca_: 1udc A: [29785]
    complexed with edo, na, nad, pge, ufm
16. Domain for 1xel:
  - Domain d1xela_: 1xel A: [29786]
    complexed with edo, na, nad, peg, upg
17. Domains for 2udp:
  1. Domain d2udpa_: 2udp A: [29791]
    complexed with edo, na, nad, upp
  2. Domain d2udpb_: 2udp B: [29792]
    complexed with edo, na, nad, upp
Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)
1. Domain for 1ek5:
  - Domain d1ek5a_: 1ek5 A: [29802]
    complexed with nad
2. Domains for 1ek6:
  1. Domain d1ek6a_: 1ek6 A: [29800]
    complexed with mg, nai, tma, upg
  2. Domain d1ek6b_: 1ek6 B: [29801]
    complexed with mg, nai, tma, upg
3. Domains for 1hzj:
  1. Domain d1hzja_: 1hzj A: [61450]
    complexed with cl, mg, nad, ud1
  2. Domain d1hzjb_: 1hzj B: [61451]
    complexed with cl, mg, nad, ud1
4. Domains for 1i3k:
  1. Domain d1i3ka_: 1i3k A: [61595]
    complexed with cl, edo, mg, nad, upg
  2. Domain d1i3kb_: 1i3k B: [61596]
    complexed with cl, edo, mg, nad, upg
5. Domains for 1i3l:
  1. Domain d1i3la_: 1i3l A: [61597]
    complexed with cl, edo, gdu, mg, nad
  2. Domain d1i3lb_: 1i3l B: [61598]
    complexed with cl, edo, gdu, mg, nad
6. Domains for 1i3m:
  1. Domain d1i3ma_: 1i3m A: [61599]
    complexed with cl, mg, nad, ud1
  2. Domain d1i3mb_: 1i3m B: [61600]
    complexed with cl, mg, nad, ud1
7. Domains for 1i3n:
  1. Domain d1i3na_: 1i3n A: [61601]
    complexed with cl, mg, nad, ud1
  2. Domain d1i3nb_: 1i3n B: [61602]
    complexed with cl, mg, nad, ud1
Trypanosome (Trypanosoma brucei) [TaxId:5691] [89519] (1 PDB entry)
- Domains for 1gy8:
  1. Domain d1gy8a_: 1gy8 A: [83376]
    complexed with nad, udp
  2. Domain d1gy8b_: 1gy8 B: [83377]
    complexed with nad, udp
  3. Domain d1gy8c_: 1gy8 C: [83378]
    complexed with nad, udp
  4. Domain d1gy8d_: 1gy8 D: [83379]
    complexed with nad, udp

More info for Protein Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) from c.2.1.2: Tyrosine-dependent oxidoreductases first appeared (with stable ids) in SCOP 1.55
Protein Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOPe 2.06
Protein Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) from c.2.1.2: Tyrosine-dependent oxidoreductases appears in the current release, SCOPe 2.08