Lineage for Family c.2.1.2: Tyrosine-dependent oxidoreductases

  1. Root: SCOP 1.71
  2. 570216Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
  3. 574151Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 574152Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 574451Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (53 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Proteins:

  1. 574452(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294] (1 species)
    peroxisomal multifunctional enzyme type 2
    segment swapping involving a C-terminal extension to the family fold
  2. 5744581,3,6,8-tetrahydroxynaphthalene reductase [63929] (1 species)
  3. 5744611,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798] (1 species)
  4. 57447311-beta-hydroxysteroid dehydrogenase 1 [117423] (2 species)
    1. 574474Species Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (1 PDB entry)
    2. 574477Species Human (Homo sapiens) [TaxId:9606] [117424] (3 PDB entries)
  5. 57449017-beta-hydroxysteroid dehydrogenase type XI [117426] (1 species)
  6. 5744942,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421] (1 species)
  7. 5745083-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)
  8. 5745183-alpha-hydroxysteroid dehydrogenase [51778] (1 species)
  9. 5745243beta/17beta hydroxysteroid dehydrogenase [82290] (1 species)
  10. 5745307-alpha-hydroxysteroid dehydrogenase [51774] (1 species)
  11. 574538ADP-L-glycero-D-mannoheptose 6-epimerase [51761] (1 species)
  12. 574550Aldehyde reductase II [117413] (1 species)
  13. 574554beta-keto acyl carrier protein reductase [51788] (5 species)
    1. 574555Species Escherichia coli [TaxId:562] [51790] (3 PDB entries)
    2. 574570Species Oil seed rape (Brassica napus) [TaxId:3708] [51789] (1 PDB entry)
    3. 574572Species Streptomyces coelicolor [TaxId:1902] [117408] (3 PDB entries)
    4. 574579Species Thermotoga maritima [TaxId:243274] [102150] (1 PDB entry)
      TM1169
    5. 574584Species Thermus thermophilus [TaxId:274] [117407] (1 PDB entry)
  14. 574593Biliverdin IX beta reductase [63931] (1 species)
    Histidine in the active site instead of the Tyr-Lys dyad
  15. 574600Carbonyl reductase [51765] (2 species)
    1. 574601Species Human (Homo sapiens) [TaxId:9606] [102144] (1 PDB entry)
      dicarbonyl/L-xylulose reductase
    2. 574604Species Mouse (Mus musculus) [TaxId:10090] [51766] (1 PDB entry)
  16. 574609Carbonyl reductase sniffer [110413] (1 species)
  17. 574612Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935] (1 species)
  18. 574615CDP-glucose-4,6-dehydratase [102136] (1 species)
  19. 574621CDP-tyvelose-2-epimerase [102138] (1 species)
  20. 574627Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780] (1 species)
  21. 574630Dihydropteridin reductase (pteridine reductase) [51769] (6 species)
    1. 574631Species Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
    2. 574633Species Leishmania major [TaxId:5664] [63926] (3 PDB entries)
    3. 574648Species Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
    4. 574653Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
    5. 574656Species Rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
    6. 574662Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
  22. 574671Drosophila alcohol dehydrogenase [51782] (2 species)
    1. 574672Species Fruit fly (Drosophila lebanonensis) [51783] (5 PDB entries)
    2. 574682Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [102147] (1 PDB entry)
  23. 574685DTDP-4-dehydrorhamnose reductase RfbD [110409] (1 species)
  24. 574690dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102] (1 species)
  25. 574696dTDP-glucose 4,6-dehydratase (RmlB) [51755] (4 species)
    1. 574697Species Escherichia coli [TaxId:562] [51756] (1 PDB entry)
    2. 574700Species Salmonella enterica [TaxId:28901] [63925] (1 PDB entry)
    3. 574705Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (6 PDB entries)
    4. 574718Species Streptomyces venezuelae [TaxId:54571] [102133] (2 PDB entries)
  26. 574721Enoyl-ACP reductase [51791] (6 species)
    1. 574722Species Escherichia coli [TaxId:562] [51794] (12 PDB entries)
    2. 574757Species Helicobacter pylori [TaxId:210] [102151] (2 PDB entries)
    3. 574766Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (6 PDB entries)
    4. 574779Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (6 PDB entries)
    5. 574797Species Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)
    6. 574803Species scop new_sp Thermus thermophilus [117409] (1 PDB entry)
  27. 574808GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757] (1 species)
  28. 574818GDP-mannose 4,6-dehydratase [51759] (4 species)
    1. 574819Species Escherichia coli [TaxId:562] [51760] (1 PDB entry)
    2. 574821Species Human (Homo sapiens) [TaxId:9606] [102135] (1 PDB entry)
    3. 574826Species Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)
    4. 574831Species Thale-cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)
  29. 574838Gluconate 5-dehydrogenase [110411] (1 species)
  30. 574842Glucose dehydrogenase [51784] (1 species)
  31. 574860Glucose dehydrogenase (5l265) [102155] (1 species)
  32. 574863Halohydrin dehalogenase HheC [102153] (1 species)
    haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
  33. 574875Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)
  34. 574900Hypothetical protein At5g02240 (T7H20_290) [117417] (1 species)
  35. 574904Hypothetical protein F25D1.5 [110415] (1 species)
  36. 574908Hypothetical protein R05D8.7 [117415] (1 species)
  37. 574914Levodione reductase [89523] (1 species)
  38. 574924Mannitol dehydrogenase [63927] (1 species)
  39. 574938meso-2,3-butanediol dehydrogenase [51786] (1 species)
  40. 574948Negative transcriptional regulator NmrA [69407] (1 species)
    has an UDP-galactose 4-epimerase-like structure but evolved a different function
  41. 574956Phenylcoumaran benzylic ether reductase [102140] (1 species)
  42. 574960Pinoresinol-lariciresinol reductase [102142] (1 species)
  43. 574966Polymyxin resistance protein ArnA (PrmI) [117419] (1 species)
    evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
  44. 574969Putative dehydrogenase ARPG836 (MGC4172) [117411] (1 species)
  45. 574975Putative oxidoreductase Rv2002 [82292] (1 species)
  46. 574987R-specific alcohol dehydrogenase [89521] (1 species)
  47. 574990Sepiapterin reductase [51767] (1 species)
  48. 574995Sorbitol dehydrogenase [102148] (1 species)
  49. 574999Sulfolipid biosynthesis protein SQD1 [51763] (1 species)
  50. 575005Tropinone reductase [51795] (3 species)
    1. 575006Species Jimsonweed (Datura stramonium), I [TaxId:4076] [51796] (1 PDB entry)
    2. 575009Species Jimsonweed (Datura stramonium), II [TaxId:4076] [51797] (4 PDB entries)
    3. 575017Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [117410] (1 PDB entry)
  51. 575019Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)
    1. 575020Species Human (Homo sapiens) [TaxId:9606] [102152] (2 PDB entries)
    2. 575026Species Rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)
    3. 575039Species Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)
  52. 575042UDP-N-acetylglucosamine 4-epimerase WbpP [110407] (1 species)
  53. 575046Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (3 species)
    1. 575047Species Escherichia coli [TaxId:562] [51753] (17 PDB entries)
    2. 575066Species Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)
    3. 575080Species Trypanosoma brucei [TaxId:5691] [89519] (1 PDB entry)

More info for Family c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Family c.2.1.2: Tyrosine-dependent oxidoreductases: