Lineage for Family c.2.1.2: Tyrosine-dependent oxidoreductases

  1. Root: SCOP 1.65
  2. 305035Class c: Alpha and beta proteins (a/b) [51349] (121 folds)
  3. 307887Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 307888Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families) (S)
  5. 308075Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (33 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Proteins:

  1. 308076(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294] (1 species)
    peroxisomal multifunctional enzyme type 2
    segment swapping involving a C-terminal extension to the family fold
  2. 3080821,3,6,8-tetrahydroxynaphthalene reductase [63929] (1 species)
  3. 3080851,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798] (1 species)
  4. 3080973-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)
  5. 3081073-alpha-hydroxysteroid dehydrogenase [51778] (1 species)
  6. 3081133-hydroxyacyl-CoA dehydrogenase [63933] (2 species)
    1. 308114Species Rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)
    2. 308127Species Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)
  7. 3081303beta/17beta hydroxysteroid dehydrogenase [82290] (1 species)
  8. 3081367-alpha-hydroxysteroid dehydrogenase [51774] (1 species)
  9. 308144ADP-L-glycero-D-mannoheptose 6-epimerase [51761] (1 species)
  10. 308156beta-keto acyl carrier protein reductase [51788] (2 species)
    1. 308157Species Escherichia coli [TaxId:562] [51790] (1 PDB entry)
    2. 308166Species Oil seed rape (Brassica napus) [TaxId:3708] [51789] (1 PDB entry)
  11. 308168Biliverdin IX beta reductase [63931] (1 species)
    Histidine in the active site instead of the Tyr-Lys dyad
  12. 308175Carbonyl reductase [51765] (1 species)
  13. 308181Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935] (1 species)
  14. 308184Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780] (1 species)
  15. 308187Dihydropteridin reductase (pteridine reductase) [51769] (4 species)
    1. 308188Species Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
    2. 308190Species Leishmania major [TaxId:5664] [63926] (2 PDB entries)
    3. 308197Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
    4. 308200Species Rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
  16. 308206Drosophila alcohol dehydrogenase [51782] (1 species)
  17. 308217dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102] (1 species)
  18. 308223dTDP-glucose 4,6-dehydratase (RmlB) [51755] (3 species)
    1. 308224Species Escherichia coli [TaxId:562] [51756] (1 PDB entry)
    2. 308227Species Salmonella enterica [TaxId:28901] [63925] (1 PDB entry)
    3. 308232Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (5 PDB entries)
  19. 308243Enoyl-ACP reductase [51791] (4 species)
    1. 308244Species Escherichia coli [TaxId:562] [51794] (12 PDB entries)
    2. 308279Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (4 PDB entries)
    3. 308288Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (4 PDB entries)
    4. 308298Species Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)
  20. 308304GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757] (1 species)
  21. 308314GDP-mannose 4,6-dehydratase [51759] (2 species)
    1. 308315Species Escherichia coli [TaxId:562] [51760] (1 PDB entry)
    2. 308317Species Thale-cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)
  22. 308324Glucose dehydrogenase [51784] (1 species)
  23. 308330Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)
  24. 308352Levodione reductase [89523] (1 species)
  25. 308362Mannitol dehydrogenase [63927] (1 species)
  26. 308376meso-2,3-butanediol dehydrogenase [51786] (1 species)
  27. 308386Negative transcriptional regulator NmrA [69407] (1 species)
    has an UDP-galactose 4-epimerase-like structure but evolved a different function
  28. 308393Putative oxidoreductase Rv2002 [82292] (1 species)
  29. 308405R-specific alcohol dehydrogenase [89521] (1 species)
  30. 308408Sepiapterin reductase [51767] (1 species)
  31. 308413Sulfolipid biosynthesis protein SQD1 [51763] (1 species)
  32. 308419Tropinone reductase [51795] (2 species)
    1. 308420Species Jimsonweed (Datura stramonium), I [TaxId:4076] [51796] (1 PDB entry)
    2. 308423Species Jimsonweed (Datura stramonium), II [TaxId:4076] [51797] (4 PDB entries)
  33. 308431Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (3 species)
    1. 308432Species Escherichia coli [TaxId:562] [51753] (17 PDB entries)
    2. 308451Species Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)
    3. 308465Species Trypanosoma brucei [TaxId:5691] [89519] (1 PDB entry)

More info for Family c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Family c.2.1.2: Tyrosine-dependent oxidoreductases: