Lineage for Protein: Alcohol dehydrogenase

  1. Root: SCOP 1.65
  2. 305035Class c: Alpha and beta proteins (a/b) [51349] (121 folds)
  3. 307887Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 307888Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families) (S)
  5. 307889Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain [51736] (8 proteins)
    N-terminal all-beta domain defines family
  6. 307901Protein Alcohol dehydrogenase [51737] (6 species)

Species:

  1. 307902Archaeon Sulfolobus solfataricus [TaxId:2287] [82286] (1 PDB entry)
  2. 307904Cod (Gadus callarias) [TaxId:8053] [51741] (1 PDB entry)
  3. 307907Frog (Rana perezi) [TaxId:8403] [89511] (2 PDB entries)
    1. Domains for 1p0c:
      1. 307910Domain d1p0ca2: 1p0c A:1164-1337 [87639]
        Other proteins in same PDB: d1p0ca1, d1p0cb1
      2. 307911Domain d1p0cb2: 1p0c B:2164-2337 [87641]
        Other proteins in same PDB: d1p0ca1, d1p0cb1
        complexed with cry, po4, zn
    2. Domains for 1p0f:
      1. 307908Domain d1p0fa2: 1p0f A:1164-1337 [87643]
        Other proteins in same PDB: d1p0fa1, d1p0fb1
      2. 307909Domain d1p0fb2: 1p0f B:2164-2337 [87645]
        Other proteins in same PDB: d1p0fa1, d1p0fb1
        complexed with cry, nap, zn
  4. 307912Horse (Equus caballus) [TaxId:9796] [51738] (31 PDB entries)
    1. Domains for 1a71:
      1. 307941Domain d1a71a2: 1a71 A:164-339 [29689]
        Other proteins in same PDB: d1a71a1, d1a71b1
      2. 307942Domain d1a71b2: 1a71 B:164-339 [29690]
        Other proteins in same PDB: d1a71a1, d1a71b1
        complexed with etf, nad, zn; mutant
    2. Domain for 1a72:
    3. Domains for 1adb:
      1. 307956Domain d1adba2: 1adb A:164-339 [29699]
        Other proteins in same PDB: d1adba1, d1adbb1
      2. 307957Domain d1adbb2: 1adb B:164-339 [29700]
        Other proteins in same PDB: d1adba1, d1adbb1
        complexed with cnd, eoh, zn
    4. Domains for 1adc:
      1. 307974Domain d1adca2: 1adc A:164-339 [29718]
        Other proteins in same PDB: d1adca1, d1adcb1
      2. 307975Domain d1adcb2: 1adc B:164-339 [29719]
        Other proteins in same PDB: d1adca1, d1adcb1
        complexed with eoh, pad, zn
    5. Domain for 1adf:
    6. Domain for 1adg:
    7. Domains for 1axe:
      1. 307947Domain d1axea2: 1axe A:164-339 [29697]
        Other proteins in same PDB: d1axea1, d1axeb1
      2. 307948Domain d1axeb2: 1axe B:164-339 [29698]
        Other proteins in same PDB: d1axea1, d1axeb1
        complexed with etf, nad, zn; mutant
    8. Domains for 1axg:
      1. 307962Domain d1axga2: 1axg A:164-339 [29707]
        Other proteins in same PDB: d1axga1, d1axgb1, d1axgc1, d1axgd1
      2. 307963Domain d1axgb2: 1axg B:164-339 [29708]
        Other proteins in same PDB: d1axga1, d1axgb1, d1axgc1, d1axgd1
      3. 307964Domain d1axgc2: 1axg C:164-339 [29709]
        Other proteins in same PDB: d1axga1, d1axgb1, d1axgc1, d1axgd1
      4. 307965Domain d1axgd2: 1axg D:164-339 [29710]
        Other proteins in same PDB: d1axga1, d1axgb1, d1axgc1, d1axgd1
        complexed with etf, nad, zn; mutant
    9. Domains for 1bto:
      1. 307949Domain d1btoa2: 1bto A:164-339 [29693]
        Other proteins in same PDB: d1btoa1, d1btob1, d1btoc1, d1btod1
      2. 307950Domain d1btob2: 1bto B:164-339 [29694]
        Other proteins in same PDB: d1btoa1, d1btob1, d1btoc1, d1btod1
      3. 307951Domain d1btoc2: 1bto C:164-339 [29695]
        Other proteins in same PDB: d1btoa1, d1btob1, d1btoc1, d1btod1
      4. 307952Domain d1btod2: 1bto D:164-339 [29696]
        Other proteins in same PDB: d1btoa1, d1btob1, d1btoc1, d1btod1
        complexed with nad, ssb, zn
    10. Domains for 1ee2:
      1. 307923Domain d1ee2a2: 1ee2 A:163-338 [29679]
        Other proteins in same PDB: d1ee2a1, d1ee2b1
      2. 307924Domain d1ee2b2: 1ee2 B:163-338 [29680]
        Other proteins in same PDB: d1ee2a1, d1ee2b1
        steroid-active isozyme
        complexed with chd, nad, zn
    11. Domains for 1het:
      1. 307913Domain d1heta2: 1het A:164-339 [60976]
        Other proteins in same PDB: d1heta1, d1hetb1
      2. 307914Domain d1hetb2: 1het B:164-339 [60978]
        Other proteins in same PDB: d1heta1, d1hetb1
        complexed with mpd, nad, zn
    12. Domains for 1heu:
      1. 307915Domain d1heua2: 1heu A:164-339 [60980]
        Other proteins in same PDB: d1heua1, d1heub1
      2. 307916Domain d1heub2: 1heu B:164-339 [60982]
        Other proteins in same PDB: d1heua1, d1heub1
        complexed with cd, mpd, nad
    13. Domains for 1hf3:
      1. 307939Domain d1hf3a2: 1hf3 A:164-339 [61001]
        Other proteins in same PDB: d1hf3a1, d1hf3b1
      2. 307940Domain d1hf3b2: 1hf3 B:164-339 [61003]
        Other proteins in same PDB: d1hf3a1, d1hf3b1
        complexed with cd, mpd, nad
    14. Domains for 1hld:
      1. 307953Domain d1hlda2: 1hld A:164-339 [29691]
        Other proteins in same PDB: d1hlda1, d1hldb1
      2. 307954Domain d1hldb2: 1hld B:164-339 [29692]
        Other proteins in same PDB: d1hlda1, d1hldb1
        complexed with brb, nad, pfb, zn
    15. Domains for 1ju9:
      1. 307943Domain d1ju9a2: 1ju9 A:164-339 [63294]
        Other proteins in same PDB: d1ju9a1, d1ju9b1
      2. 307944Domain d1ju9b2: 1ju9 B:164-339 [63296]
        Other proteins in same PDB: d1ju9a1, d1ju9b1
        complexed with nad, zn; mutant
    16. Domains for 1lde:
      1. 307958Domain d1ldea2: 1lde A:164-339 [29702]
        Other proteins in same PDB: d1ldea1, d1ldeb1, d1ldec1, d1lded1
      2. 307959Domain d1ldeb2: 1lde B:164-339 [29703]
        Other proteins in same PDB: d1ldea1, d1ldeb1, d1ldec1, d1lded1
      3. 307960Domain d1ldec2: 1lde C:164-339 [29704]
        Other proteins in same PDB: d1ldea1, d1ldeb1, d1ldec1, d1lded1
      4. 307961Domain d1lded2: 1lde D:164-339 [29705]
        Other proteins in same PDB: d1ldea1, d1ldeb1, d1ldec1, d1lded1
        complexed with fpi, nad, zn
    17. Domains for 1ldy:
      1. 307969Domain d1ldya2: 1ldy A:164-339 [29711]
        Other proteins in same PDB: d1ldya1, d1ldyb1, d1ldyc1, d1ldyd1
      2. 307970Domain d1ldyb2: 1ldy B:164-339 [29712]
        Other proteins in same PDB: d1ldya1, d1ldyb1, d1ldyc1, d1ldyd1
      3. 307971Domain d1ldyc2: 1ldy C:164-339 [29713]
        Other proteins in same PDB: d1ldya1, d1ldyb1, d1ldyc1, d1ldyd1
      4. 307972Domain d1ldyd2: 1ldy D:164-339 [29714]
        Other proteins in same PDB: d1ldya1, d1ldyb1, d1ldyc1, d1ldyd1
        complexed with cxf, nad, zn
    18. Domains for 1mg0:
      1. 307933Domain d1mg0a2: 1mg0 A:164-339 [79052]
        Other proteins in same PDB: d1mg0a1, d1mg0b1, d1mg0c1, d1mg0d1
      2. 307934Domain d1mg0b2: 1mg0 B:164-339 [79054]
        Other proteins in same PDB: d1mg0a1, d1mg0b1, d1mg0c1, d1mg0d1
      3. 307935Domain d1mg0c2: 1mg0 C:164-339 [79056]
        Other proteins in same PDB: d1mg0a1, d1mg0b1, d1mg0c1, d1mg0d1
      4. 307936Domain d1mg0d2: 1mg0 D:164-339 [79058]
        Other proteins in same PDB: d1mg0a1, d1mg0b1, d1mg0c1, d1mg0d1
        complexed with dfb, nad, zn
    19. Domains for 1mgo:
      1. 307919Domain d1mgoa2: 1mgo A:164-339 [79095]
        Other proteins in same PDB: d1mgoa1, d1mgob1
      2. 307920Domain d1mgob2: 1mgo B:164-339 [79097]
        Other proteins in same PDB: d1mgoa1, d1mgob1
        complexed with mpd, nad, pfb, zn; mutant
    20. Domains for 1n8k:
      1. 307917Domain d1n8ka2: 1n8k A:164-339 [80299]
        Other proteins in same PDB: d1n8ka1, d1n8kb1
      2. 307918Domain d1n8kb2: 1n8k B:164-339 [80301]
        Other proteins in same PDB: d1n8ka1, d1n8kb1
        complexed with mpd, naj, pzo, zn; mutant
    21. Domains for 1n92:
      1. 307921Domain d1n92a2: 1n92 A:164-339 [80328]
        Other proteins in same PDB: d1n92a1, d1n92b1
      2. 307922Domain d1n92b2: 1n92 B:164-339 [80330]
        Other proteins in same PDB: d1n92a1, d1n92b1
        complexed with mpd, naj, pyz, zn
    22. Domains for 1p1r:
      1. 307925Domain d1p1ra2: 1p1r A:164-339 [87704]
        Other proteins in same PDB: d1p1ra1, d1p1rb1, d1p1rc1, d1p1rd1
      2. 307926Domain d1p1rb2: 1p1r B:164-339 [87706]
        Other proteins in same PDB: d1p1ra1, d1p1rb1, d1p1rc1, d1p1rd1
      3. 307927Domain d1p1rc2: 1p1r C:164-339 [87708]
        Other proteins in same PDB: d1p1ra1, d1p1rb1, d1p1rc1, d1p1rd1
      4. 307928Domain d1p1rd2: 1p1r D:164-339 [87710]
        Other proteins in same PDB: d1p1ra1, d1p1rb1, d1p1rc1, d1p1rd1
        complexed with mpd, naj, nmh, zn
    23. Domain for 1qlh:
    24. Domain for 1qlj:
    25. Domains for 2ohx:
      1. 307937Domain d2ohxa2: 2ohx A:164-339 [29685]
        Other proteins in same PDB: d2ohxa1, d2ohxb1
      2. 307938Domain d2ohxb2: 2ohx B:164-339 [29686]
        Other proteins in same PDB: d2ohxa1, d2ohxb1
        complexed with dms, nad, zn
    26. Domains for 2oxi:
      1. 307945Domain d2oxia2: 2oxi A:164-339 [29687]
        Other proteins in same PDB: d2oxia1, d2oxib1
      2. 307946Domain d2oxib2: 2oxi B:164-339 [29688]
        Other proteins in same PDB: d2oxia1, d2oxib1
        complexed with cu, dms, nad, zn
    27. Domains for 3bto:
      1. 307929Domain d3btoa2: 3bto A:164-339 [29681]
        Other proteins in same PDB: d3btoa1, d3btob1, d3btoc1, d3btod1
      2. 307930Domain d3btob2: 3bto B:164-339 [29682]
        Other proteins in same PDB: d3btoa1, d3btob1, d3btoc1, d3btod1
      3. 307931Domain d3btoc2: 3bto C:164-339 [29683]
        Other proteins in same PDB: d3btoa1, d3btob1, d3btoc1, d3btod1
      4. 307932Domain d3btod2: 3bto D:164-339 [29684]
        Other proteins in same PDB: d3btoa1, d3btob1, d3btoc1, d3btod1
        complexed with nad, ssb, zn
    28. Domain for 5adh:
    29. Domains for 6adh:
      1. 307978Domain d6adha2: 6adh A:164-339 [29722]
        Other proteins in same PDB: d6adha1, d6adhb1
      2. 307979Domain d6adhb2: 6adh B:164-339 [29723]
        Other proteins in same PDB: d6adha1, d6adhb1
        complexed with dms, nad, zn
    30. Domain for 7adh:
    31. Domain for 8adh:
  5. 307981Human (Homo sapiens), different isozymes [TaxId:9606] [51739] (18 PDB entries)
    1. Domains for 1agn:
      1. 308018Domain d1agna2: 1agn A:163-338 [29753]
        Other proteins in same PDB: d1agna1, d1agnb1, d1agnc1, d1agnd1
      2. 308019Domain d1agnb2: 1agn B:163-338 [29754]
        Other proteins in same PDB: d1agna1, d1agnb1, d1agnc1, d1agnd1
      3. 308020Domain d1agnc2: 1agn C:163-338 [29755]
        Other proteins in same PDB: d1agna1, d1agnb1, d1agnc1, d1agnd1
      4. 308021Domain d1agnd2: 1agn D:163-338 [29756]
        Other proteins in same PDB: d1agna1, d1agnb1, d1agnc1, d1agnd1
        sigma isozyme
        complexed with act, nad, zn
    2. Domains for 1d1s:
      1. 308010Domain d1d1sa2: 1d1s A:163-338 [29743]
        Other proteins in same PDB: d1d1sa1, d1d1sb1, d1d1sc1, d1d1sd1
      2. 308011Domain d1d1sb2: 1d1s B:163-338 [29744]
        Other proteins in same PDB: d1d1sa1, d1d1sb1, d1d1sc1, d1d1sd1
      3. 308012Domain d1d1sc2: 1d1s C:163-338 [29745]
        Other proteins in same PDB: d1d1sa1, d1d1sb1, d1d1sc1, d1d1sd1
      4. 308013Domain d1d1sd2: 1d1s D:163-338 [29746]
        Other proteins in same PDB: d1d1sa1, d1d1sb1, d1d1sc1, d1d1sd1
        sigma isozyme
        complexed with act, cac, nad, zn
    3. Domains for 1d1t:
      1. 307998Domain d1d1ta2: 1d1t A:163-338 [29735]
        Other proteins in same PDB: d1d1ta1, d1d1tb1, d1d1tc1, d1d1td1
      2. 307999Domain d1d1tb2: 1d1t B:163-338 [29736]
        Other proteins in same PDB: d1d1ta1, d1d1tb1, d1d1tc1, d1d1td1
      3. 308000Domain d1d1tc2: 1d1t C:163-338 [29737]
        Other proteins in same PDB: d1d1ta1, d1d1tb1, d1d1tc1, d1d1td1
      4. 308001Domain d1d1td2: 1d1t D:163-338 [29738]
        Other proteins in same PDB: d1d1ta1, d1d1tb1, d1d1tc1, d1d1td1
        sigma isozyme
        complexed with act, cac, nad, zn; mutant
    4. Domains for 1deh:
      1. 307990Domain d1deha2: 1deh A:163-338 [29729]
        Other proteins in same PDB: d1deha1, d1dehb1
      2. 307991Domain d1dehb2: 1deh B:163-338 [29730]
        Other proteins in same PDB: d1deha1, d1dehb1
        complexed with cl, nad, pyz, zn
    5. Domains for 1hdx:
      1. 308002Domain d1hdxa2: 1hdx A:163-338 [29733]
        Other proteins in same PDB: d1hdxa1, d1hdxb1
      2. 308003Domain d1hdxb2: 1hdx B:163-338 [29734]
        Other proteins in same PDB: d1hdxa1, d1hdxb1
        complexed with cl, cxl, nad, zn
    6. Domains for 1hdy:
      1. 308004Domain d1hdya2: 1hdy A:163-338 [29739]
        Other proteins in same PDB: d1hdya1, d1hdyb1
      2. 308005Domain d1hdyb2: 1hdy B:163-338 [29740]
        Other proteins in same PDB: d1hdya1, d1hdyb1
        complexed with cl, nad, pyz, zn
    7. Domains for 1hdz:
      1. 308006Domain d1hdza2: 1hdz A:163-338 [29741]
        Other proteins in same PDB: d1hdza1, d1hdzb1
      2. 308007Domain d1hdzb2: 1hdz B:163-338 [29742]
        Other proteins in same PDB: d1hdza1, d1hdzb1
        complexed with cl, nad, zn; mutant
    8. Domains for 1hso:
      1. 308014Domain d1hsoa2: 1hso A:163-338 [29747]
        Other proteins in same PDB: d1hsoa1, d1hsob1
      2. 308015Domain d1hsob2: 1hso B:163-338 [29748]
        Other proteins in same PDB: d1hsoa1, d1hsob1
        alpha isozyme
        complexed with nad, pyz, zn
    9. Domains for 1hsz:
      1. 307986Domain d1hsza2: 1hsz A:163-338 [29727]
        Other proteins in same PDB: d1hsza1, d1hszb1
      2. 307987Domain d1hszb2: 1hsz B:163-338 [29728]
        Other proteins in same PDB: d1hsza1, d1hszb1
        beta-1 isozyme
        complexed with nad, po4, zn
    10. Domains for 1ht0:
      1. 307982Domain d1ht0a2: 1ht0 A:163-338 [29725]
        Other proteins in same PDB: d1ht0a1, d1ht0b1
      2. 307983Domain d1ht0b2: 1ht0 B:163-338 [29726]
        Other proteins in same PDB: d1ht0a1, d1ht0b1
        gamma-2 isozyme
        complexed with nad, zn; mutant
    11. Domains for 1htb:
      1. 307996Domain d1htba2: 1htb A:163-338 [29731]
        Other proteins in same PDB: d1htba1, d1htbb1
      2. 307997Domain d1htbb2: 1htb B:163-338 [29732]
        Other proteins in same PDB: d1htba1, d1htbb1
        complexed with cl, nad, pyz, zn
    12. Domains for 1m6h:
      1. 307984Domain d1m6ha2: 1m6h A:163-338 [74530]
        Other proteins in same PDB: d1m6ha1, d1m6hb1
      2. 307985Domain d1m6hb2: 1m6h B:163-338 [74532]
        Other proteins in same PDB: d1m6ha1, d1m6hb1
        glutathione-dependent formaldehyde dehydrogenase
        complexed with k, po4, zn
    13. Domains for 1m6w:
      1. 307992Domain d1m6wa2: 1m6w A:163-338 [74569]
        Other proteins in same PDB: d1m6wa1, d1m6wb1
      2. 307993Domain d1m6wb2: 1m6w B:163-338 [74571]
        Other proteins in same PDB: d1m6wa1, d1m6wb1
        glutathione-dependent formaldehyde dehydrogenase
        complexed with 12h, k, po4, zn
    14. Domains for 1ma0:
      1. 307994Domain d1ma0a2: 1ma0 A:163-338 [74606]
        Other proteins in same PDB: d1ma0a1, d1ma0b1
      2. 307995Domain d1ma0b2: 1ma0 B:163-338 [74608]
        Other proteins in same PDB: d1ma0a1, d1ma0b1
        glutathione-dependent formaldehyde dehydrogenase
        complexed with k, lau, nad, po4, zn
    15. Domains for 1mc5:
      1. 308008Domain d1mc5a2: 1mc5 A:163-338 [84930]
        Other proteins in same PDB: d1mc5a1, d1mc5b1
      2. 308009Domain d1mc5b2: 1mc5 B:163-338 [84932]
        Other proteins in same PDB: d1mc5a1, d1mc5b1
        glutathione-dependent formaldehyde dehydrogenase
        complexed with ahe, k, nad, po4, zn
    16. Domains for 1mp0:
      1. 307988Domain d1mp0a2: 1mp0 A:163-338 [79371]
        Other proteins in same PDB: d1mp0a1, d1mp0b1
      2. 307989Domain d1mp0b2: 1mp0 B:163-338 [79373]
        Other proteins in same PDB: d1mp0a1, d1mp0b1
        glutathione-dependent formaldehyde dehydrogenase
        complexed with k, nad, po4, zn
    17. Domains for 1teh:
      1. 308016Domain d1teha2: 1teh A:163-338 [29749]
        Other proteins in same PDB: d1teha1, d1tehb1
      2. 308017Domain d1tehb2: 1teh B:163-338 [29750]
        Other proteins in same PDB: d1teha1, d1tehb1
        glutathione-dependent formaldehyde dehydrogenase
        complexed with nad, zn
    18. Domains for 3hud:
      1. 308022Domain d3huda2: 3hud A:163-338 [29751]
        Other proteins in same PDB: d3huda1, d3hudb1
      2. 308023Domain d3hudb2: 3hud B:163-338 [29752]
        Other proteins in same PDB: d3huda1, d3hudb1
        complexed with nad, zn
  6. 308024Mouse (Mus musculus), class II [TaxId:10090] [51740] (3 PDB entries)
    1. Domains for 1e3e:
      1. 308027Domain d1e3ea2: 1e3e A:168-341 [29759]
        Other proteins in same PDB: d1e3ea1, d1e3eb1
      2. 308028Domain d1e3eb2: 1e3e B:168-341 [29760]
        Other proteins in same PDB: d1e3ea1, d1e3eb1
        complexed with nad, zn
    2. Domains for 1e3i:
      1. 308025Domain d1e3ia2: 1e3i A:168-341 [29757]
        Other proteins in same PDB: d1e3ia1, d1e3ib1
      2. 308026Domain d1e3ib2: 1e3i B:168-341 [29758]
        Other proteins in same PDB: d1e3ia1, d1e3ib1
        complexed with cxf, nad, zn
    3. Domains for 1e3l:
      1. 308029Domain d1e3la2: 1e3l A:168-341 [29761]
        Other proteins in same PDB: d1e3la1, d1e3lb1
      2. 308030Domain d1e3lb2: 1e3l B:168-341 [29762]
        Other proteins in same PDB: d1e3la1, d1e3lb1
        complexed with nad, zn; mutant

More info for Protein Alcohol dehydrogenase from c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain

Timeline for Protein Alcohol dehydrogenase from c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain: