SCOPe 2.02: Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain

Lineage for Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain

1. Root: SCOPe 2.02

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain [51736] (16 proteins)
   N-terminal all-beta domain defines family

Proteins:

1. 2,4-dienoyl-CoA reductase [89517] (1 species)

   • Species Yeast (Candida tropicalis) [TaxId:5482] [89518] (5 PDB entries)

2. Alcohol dehydrogenase [51737] (9 species)

   1. Species Aeropyrum pernix [TaxId:56636] [102121] (1 PDB entry)

   2. Species Bacillus stearothermophilus [TaxId:1422] [102123] (1 PDB entry)

   3. Species Cod (Gadus callarias) [TaxId:8053] [51741] (1 PDB entry)

   4. Species Frog (Rana perezi) [TaxId:8403] [89511] (2 PDB entries)

   5. Species Horse (Equus caballus) [TaxId:9796] [51738] (36 PDB entries)
      Uniprot P00327

   6. Species Human (Homo sapiens), different isozymes [TaxId:9606] [51739] (24 PDB entries)
      Uniprot P00326 ! Uniprot P00325 ! Uniprot P07327

   7. Species Mouse (Mus musculus), class II [TaxId:10090] [51740] (3 PDB entries)

   8. Species Pseudomonas aeruginosa [TaxId:287] [102122] (1 PDB entry)

   9. Species Sulfolobus solfataricus [TaxId:2287] [82286] (4 PDB entries)

3. B. subtilis YhfP homologue [117403] (1 species)

   • Species Bacillus stearothermophilus [TaxId:1422] [117404] (1 PDB entry)
     Uniprot Q5L022; 96% sequence identity; Geobacillus kaustophilus TaxID:1462

4. Bacterial secondary alcohol dehydrogenase [51742] (2 species)

   1. Species Clostridium beijerinckii [TaxId:1520] [51743] (4 PDB entries)

   2. Species Thermoanaerobacter brockii [TaxId:29323] [51744] (3 PDB entries)

5. Benzyl alcohol dehydrogenase [89512] (1 species)

   • Species Acinetobacter calcoaceticus [TaxId:471] [89513] (1 PDB entry)

6. Cinnamyl alcohol dehydrogenase, ADH6 [110403] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [110404] (3 PDB entries)
     Uniprot Q04894

7. Formaldehyde dehydrogenase [82287] (1 species)

   • Species Pseudomonas putida [TaxId:303] [82288] (1 PDB entry)

8. Hypothetical protein TM0436 [102124] (1 species)

   • Species Thermotoga maritima [TaxId:2336] [102125] (1 PDB entry)

9. Hypothetical protein YahK [102128] (1 species)

   • Species Escherichia coli [TaxId:562] [102129] (1 PDB entry)

10. Hypothetical protein YhdH [102126] (1 species)

    • Species Escherichia coli [TaxId:562] [102127] (2 PDB entries)
      Uniprot P26646

11. Hypothetical protein YhfP [117405] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [117406] (2 PDB entries)
      Uniprot O07615

12. Ketose reductase (sorbitol dehydrogenase) [51745] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [102130] (3 PDB entries)

    2. Species Silverleaf whitefly (Bemisia argentifolii) [TaxId:77855] [51746] (1 PDB entry)

13. Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase [110405] (1 species)

    • Species Guinea pig (Cavia porcellus) [TaxId:10141] [110406] (4 PDB entries)
      Uniprot Q9EQZ5

14. Putative enoyl reductase domain of polyketide synthase [89515] (1 species)

    • Species Mycobacterium tuberculosis [TaxId:1773] [89516] (1 PDB entry)

15. Putative zinc-binding alcohol dehydrogenase [102131] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [102132] (1 PDB entry)

16. Quinone oxidoreductase [51747] (3 species)

    1. Species Escherichia coli [TaxId:562] [51748] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [117402] (1 PDB entry)
       Uniprot Q08257

    3. Species Thermus thermophilus [TaxId:274] [89514] (2 PDB entries)

More info for Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain

Timeline for Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain:

• Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain first appeared (with stable ids) in SCOP 1.55, called Family c.2.1.1: Alcohol/glucose dehydrogenases, C-terminal domain
  
• Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain appears in SCOPe 2.01
  
• Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain appears in SCOPe 2.03
  
• Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain appears in the current release, SCOPe 2.08