SCOP 1.67: Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain

Lineage for Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (11 families)

5. Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain [51736] (12 proteins)
   N-terminal all-beta domain defines family

Proteins:

1. 2,4-dienoyl-CoA reductase [89517] (1 species)

   • Species Yeast (Candida tropicalis) [TaxId:5482] [89518] (5 PDB entries)

2. Alcohol dehydrogenase [51737] (9 species)

   1. Species Archaeon Aeropyrum pernix [TaxId:56636] [102121] (1 PDB entry)

   2. Species Archaeon Sulfolobus solfataricus [TaxId:2287] [82286] (4 PDB entries)

   3. Species Bacillus stearothermophilus [TaxId:1422] [102123] (1 PDB entry)

   4. Species Cod (Gadus callarias) [TaxId:8053] [51741] (1 PDB entry)

   5. Species Frog (Rana perezi) [TaxId:8403] [89511] (2 PDB entries)

   6. Species Horse (Equus caballus) [TaxId:9796] [51738] (33 PDB entries)

   7. Species Human (Homo sapiens), different isozymes [TaxId:9606] [51739] (18 PDB entries)

   8. Species Mouse (Mus musculus), class II [TaxId:10090] [51740] (3 PDB entries)

   9. Species Pseudomonas aeruginosa [TaxId:287] [102122] (1 PDB entry)

3. Bacterial secondary alcohol dehydrogenase [51742] (2 species)

   1. Species Clostridium beijerinckii [51743] (3 PDB entries)

   2. Species Thermoanaerobacter brockii [TaxId:29323] [51744] (2 PDB entries)

4. Benzyl alcohol dehydrogenase [89512] (1 species)

   • Species Acinetobacter calcoaceticus [TaxId:471] [89513] (1 PDB entry)

5. Formaldehyde dehydrogenase [82287] (1 species)

   • Species Pseudomonas putida [TaxId:303] [82288] (1 PDB entry)

6. Hypothetical protein TM0436 [102124] (1 species)

   • Species Thermotoga maritima [TaxId:243274] [102125] (1 PDB entry)

7. Hypothetical protein YahK [102128] (1 species)

   • Species Escherichia coli [TaxId:562] [102129] (1 PDB entry)

8. Hypothetical protein YhdH [102126] (1 species)

   • Species Escherichia coli [TaxId:562] [102127] (1 PDB entry)

9. Ketose reductase (sorbitol dehydrogenase) [51745] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [102130] (3 PDB entries)

   2. Species Silverleaf whitefly (Bemisia argentifolii) [TaxId:77855] [51746] (1 PDB entry)

10. Putative enoyl reductase domain of polyketide synthase [89515] (1 species)

    • Species Mycobacterium tuberculosis [TaxId:1773] [89516] (1 PDB entry)

11. Putative zinc-binding alcohol dehydrogenase [102131] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [102132] (1 PDB entry)

12. Quinone oxidoreductase [51747] (2 species)

    1. Species Escherichia coli [TaxId:562] [51748] (1 PDB entry)

    2. Species Thermus thermophilus [TaxId:274] [89514] (2 PDB entries)

More info for Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain

Timeline for Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain:

• Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain first appeared (with stable ids) in SCOP 1.55, called Family c.2.1.1: Alcohol/glucose dehydrogenases, C-terminal domain
  
• Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain appears in SCOP 1.65
  
• Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain appears in SCOP 1.69
  
• Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain appears in the current release, SCOPe 2.08