Lineage for Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain

  1. Root: SCOPe 2.08
  2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain [51736] (19 proteins)
    N-terminal all-beta domain defines family

Proteins:

  1. 2,4-dienoyl-CoA reductase [89517] (1 species)
  2. Alcohol dehydrogenase [51737] (9 species)
    1. Species Aeropyrum pernix [TaxId:56636] [102121] (1 PDB entry)
    2. Species Bacillus stearothermophilus [TaxId:1422] [102123] (1 PDB entry)
    3. Species Cod (Gadus callarias) [TaxId:8053] [51741] (1 PDB entry)
    4. Species Frog (Rana perezi) [TaxId:8403] [89511] (2 PDB entries)
    5. Species Horse (Equus caballus) [TaxId:9796] [51738] (52 PDB entries)
      Uniprot P00327
    6. Species Human (Homo sapiens), different isozymes [TaxId:9606] [51739] (24 PDB entries)
      Uniprot P00326 ! Uniprot P00325 ! Uniprot P07327
    7. Species Mouse (Mus musculus), class II [TaxId:10090] [51740] (3 PDB entries)
    8. Species Pseudomonas aeruginosa [TaxId:287] [102122] (1 PDB entry)
    9. Species Sulfolobus solfataricus [TaxId:2287] [82286] (4 PDB entries)
  3. B. subtilis YhfP homologue [117403] (1 species)
  4. Bacterial secondary alcohol dehydrogenase [51742] (2 species)
    1. Species Clostridium beijerinckii [TaxId:1520] [51743] (4 PDB entries)
    2. Species Thermoanaerobacter brockii [TaxId:29323] [51744] (3 PDB entries)
  5. Benzyl alcohol dehydrogenase [89512] (1 species)
  6. Cinnamyl alcohol dehydrogenase, ADH6 [110403] (1 species)
  7. Formaldehyde dehydrogenase [82287] (1 species)
  8. Hypothetical protein TM0436 [102124] (1 species)
  9. Hypothetical protein YahK [102128] (1 species)
  10. Hypothetical protein YhdH [102126] (1 species)
  11. Hypothetical protein YhfP [117405] (1 species)
  12. Ketose reductase (sorbitol dehydrogenase) [51745] (2 species)
    1. Species Human (Homo sapiens) [TaxId:9606] [102130] (3 PDB entries)
    2. Species Silverleaf whitefly (Bemisia argentifolii) [TaxId:77855] [51746] (1 PDB entry)
  13. Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase [110405] (1 species)
  14. Putative enoyl reductase domain of polyketide synthase [89515] (1 species)
  15. Putative zinc-binding alcohol dehydrogenase [102131] (1 species)
  16. Quinone oxidoreductase [51747] (3 species)
    1. Species Escherichia coli [TaxId:562] [51748] (1 PDB entry)
    2. Species Human (Homo sapiens) [TaxId:9606] [117402] (1 PDB entry)
      Uniprot Q08257
    3. Species Thermus thermophilus [TaxId:274] [89514] (2 PDB entries)
  17. automated matches [275621] (1 species)
    not a true protein
  18. Enoylreductase substrate-binding domain from fatty acid synthase (FAS) [419110] (1 species)
  19. Enoylreductase nucleotide-binding domain from fatty acid synthase (FAS) [419111] (1 species)

More info for Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain

Timeline for Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain: