SCOPe 2.05: Family c.1.23.1: Methylenetetrahydrofolate reductase

Lineage for Family c.1.23.1: Methylenetetrahydrofolate reductase

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.23: FAD-linked oxidoreductase [51730] (2 families)
   distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation

5. Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 proteins)
   automatically mapped to Pfam PF02219

Proteins:

1. Methylenetetrahydrofolate reductase [51732] (2 species)

   1. Species Escherichia coli [TaxId:562] [51733] (7 PDB entries)

   2. Species Thermus thermophilus [TaxId:274] [102106] (1 PDB entry)

2. automated matches [193645] (2 species)
   not a true protein

   1. Species Escherichia coli K-12 [TaxId:83333] [225710] (2 PDB entries)

   2. Species Thermus thermophilus HB8 [TaxId:300852] [193648] (2 PDB entries)

More info for Family c.1.23.1: Methylenetetrahydrofolate reductase

Timeline for Family c.1.23.1: Methylenetetrahydrofolate reductase:

• Family c.1.23.1: Methylenetetrahydrofolate reductase first appeared (with stable ids) in SCOP 1.55
  
• Family c.1.23.1: Methylenetetrahydrofolate reductase appears in SCOPe 2.04
  
• Family c.1.23.1: Methylenetetrahydrofolate reductase appears in SCOPe 2.06
  
• Family c.1.23.1: Methylenetetrahydrofolate reductase appears in the current release, SCOPe 2.08