SCOPe 2.05: Protein: Isocitrate lyase

Lineage for Protein: Isocitrate lyase

Root: SCOPe 2.05
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites

Superfamily c.1.12: Phosphoenolpyruvate/pyruvate domain [51621] (8 families)
Family c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like [88704] (4 proteins)
forms a swapped dimer
Protein Isocitrate lyase [51642] (3 species)
elaborated with additional subdomains

Species:

Emericella nidulans (Aspergillus nidulans) [TaxId:162425] [51643] (1 PDB entry)
- Domain for 1dqu:
  - Domain d1dqua_: 1dqu A: [29314]
Escherichia coli [TaxId:562] [63923] (1 PDB entry)
- Domains for 1igw:
  1. Domain d1igwa_: 1igw A: [62370]
    complexed with hg, mg, pyr; mutant
  2. Domain d1igwb_: 1igw B: [62371]
    complexed with hg, mg, pyr; mutant
  3. Domain d1igwc_: 1igw C: [62372]
    complexed with hg, mg, pyr; mutant
  4. Domain d1igwd_: 1igw D: [62373]
    complexed with hg, mg, pyr; mutant
Mycobacterium tuberculosis [TaxId:1773] [51644] (3 PDB entries)
1. Domains for 1f61:
  1. Domain d1f61a_: 1f61 A: [29319]
    complexed with mg
  2. Domain d1f61b_: 1f61 B: [29320]
    complexed with mg
2. Domains for 1f8i:
  1. Domain d1f8ia_: 1f8i A: [29321]
    complexed with glv, mg, sin
  2. Domain d1f8ib_: 1f8i B: [29322]
    complexed with glv, mg, sin
  3. Domain d1f8ic_: 1f8i C: [29323]
    complexed with glv, mg, sin
  4. Domain d1f8id_: 1f8i D: [29324]
    complexed with glv, mg, sin
3. Domains for 1f8m:
  1. Domain d1f8ma_: 1f8m A: [29315]
    complexed with mg, pyr
  2. Domain d1f8mb_: 1f8m B: [29316]
    complexed with mg, pyr
  3. Domain d1f8mc_: 1f8m C: [29317]
    complexed with mg, pyr
  4. Domain d1f8md_: 1f8m D: [29318]
    complexed with mg, pyr

More info for Protein Isocitrate lyase from c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like

Timeline for Protein Isocitrate lyase from c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like:

Protein Isocitrate lyase from c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like first appeared (with stable ids) in SCOP 1.55, called Protein Isocitrate lyase from c.1.12.6: Isocitrate lyase
Protein Isocitrate lyase from c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like appears in SCOPe 2.04
Protein Isocitrate lyase from c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like appears in SCOPe 2.06
Protein Isocitrate lyase from c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like appears in the current release, SCOPe 2.08