SCOP 1.75: Family c.1.12.5: HpcH/HpaI aldolase

Lineage for Family c.1.12.5: HpcH/HpaI aldolase

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.12: Phosphoenolpyruvate/pyruvate domain [51621] (7 families)

5. Family c.1.12.5: HpcH/HpaI aldolase [51638] (3 proteins)
   forms a swapped dimer; contains a PK-type metal-binding site

Proteins:

1. 2-dehydro-3-deoxy-galactarate aldolase [51639] (1 species)

   • Species Escherichia coli [TaxId:562] [51640] (2 PDB entries)

2. Citrate lyase, beta subunit [110375] (2 species)
   non-swapped trimer

   1. Species Deinococcus radiodurans [TaxId:1299] [110376] (1 PDB entry)
      Uniprot Q9RUZ0 4-234

   2. Species Mycobacterium tuberculosis [TaxId:1773] [117388] (2 PDB entries)
      Uniprot O06162

3. Macrophomate synthase [89501] (1 species)
   Intermolecular Diels-Alderase

   • Species Macrophoma commelinae [TaxId:108330] [89502] (1 PDB entry)

More info for Family c.1.12.5: HpcH/HpaI aldolase

Timeline for Family c.1.12.5: HpcH/HpaI aldolase:

• Family c.1.12.5: HpcH/HpaI aldolase first appeared (with stable ids) in SCOP 1.55, called Family c.1.12.5: 2-dehydro-3-deoxy-galactarate aldolase
  
• Family c.1.12.5: HpcH/HpaI aldolase appears in SCOP 1.73
  
• Family c.1.12.5: HpcH/HpaI aldolase appears in SCOPe 2.01
  
• Family c.1.12.5: HpcH/HpaI aldolase appears in the current release, SCOPe 2.08