Lineage for Protein: 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8P synthase)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2413227Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2420459Superfamily c.1.10: Aldolase [51569] (9 families) (S)
    Common fold covers whole protein structure
  5. 2421459Family c.1.10.4: Class I DAHP synthetase [51599] (3 protein domains)
  6. 2421536Protein 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8P synthase) [51602] (4 species)

Species:

  1. 2421537Aquifex aeolicus [TaxId:63363] [63922] (32 PDB entries)
    1. Domains for 1fwn:
      1. 2421560Domain d1fwna_: 1fwn A: [60060]
        complexed with pep, po4
      2. 2421561Domain d1fwnb_: 1fwn B: [60061]
        complexed with pep, po4
    2. Domains for 1fws:
      1. 2421620Domain d1fwsa_: 1fws A: [60063]
        complexed with cd, pep, po4
      2. 2421621Domain d1fwsb_: 1fws B: [60064]
        complexed with cd, pep, po4
    3. Domains for 1fwt:
      1. 2421624Domain d1fwta_: 1fwt A: [60065]
        complexed with cd, e4p, pep, po4
      2. 2421625Domain d1fwtb_: 1fwt B: [60066]
        complexed with cd, e4p, pep, po4
    4. Domains for 1fww:
      1. 2421616Domain d1fwwa_: 1fww A: [60067]
        complexed with a5p, cd, pep, po4
      2. 2421617Domain d1fwwb_: 1fww B: [60068]
        complexed with a5p, cd, pep, po4
    5. Domains for 1fx6:
      1. 2421628Domain d1fx6a_: 1fx6 A: [60086]
        complexed with po4
      2. 2421629Domain d1fx6b_: 1fx6 B: [60087]
        complexed with po4
    6. Domains for 1fxp:
      1. 2421602Domain d1fxpa_: 1fxp A: [60106]
        complexed with cd, po4
      2. 2421603Domain d1fxpb_: 1fxp B: [60107]
        complexed with cd, po4
    7. Domains for 1fxq:
      1. 2421596Domain d1fxqa_: 1fxq A: [60108]
        complexed with a5p, pep
      2. 2421597Domain d1fxqb_: 1fxq B: [60109]
        complexed with a5p, pep
    8. Domains for 1fy6:
      1. 2421618Domain d1fy6a_: 1fy6 A: [60111]
        complexed with a5p, cd, po4
      2. 2421619Domain d1fy6b_: 1fy6 B: [60112]
        complexed with a5p, cd, po4
    9. Domains for 1jcx:
      1. 2421598Domain d1jcxa_: 1jcx A: [66510]
        complexed with cd, pai
      2. 2421599Domain d1jcxb_: 1jcx B: [66511]
        complexed with cd, pai
    10. Domains for 1jcy:
      1. 2421622Domain d1jcya_: 1jcy A: [66512]
        complexed with cd, pep, po4, r5p
      2. 2421623Domain d1jcyb_: 1jcy B: [66513]
        complexed with cd, pep, po4, r5p
    11. Domains for 1lrn:
      1. 2421630Domain d1lrna_: 1lrn A: [78159]
        complexed with cd, po4; mutant
      2. 2421631Domain d1lrnb_: 1lrn B: [78160]
        complexed with cd, po4; mutant
    12. Domains for 1lro:
      1. 2421594Domain d1lroa_: 1lro A: [78161]
        complexed with cd, pep, po4; mutant
      2. 2421595Domain d1lrob_: 1lro B: [78162]
        complexed with cd, pep, po4; mutant
    13. Domains for 1lrq:
      1. 2421592Domain d1lrqa_: 1lrq A: [78163]
        complexed with a5p, cd, pep, po4; mutant
      2. 2421593Domain d1lrqb_: 1lrq B: [78164]
        complexed with a5p, cd, pep, po4; mutant
    14. Domains for 1pck:
      1. 2421548Domain d1pcka_: 1pck A: [94438]
        complexed with cd, pez, po4
      2. 2421549Domain d1pckb_: 1pck B: [94439]
        complexed with cd, pez, po4
    15. Domains for 1pcw:
      1. 2421550Domain d1pcwa_: 1pcw A: [94495]
        complexed with cd, h4p
      2. 2421551Domain d1pcwb_: 1pcw B: [94496]
        complexed with cd, h4p
    16. Domains for 1pe1:
      1. 2421544Domain d1pe1a_: 1pe1 A: [94591]
        complexed with 2pg, cd, po4
      2. 2421545Domain d1pe1b_: 1pe1 B: [94592]
        complexed with 2pg, cd, po4
    17. Domains for 1t8x:
      1. 2421546Domain d1t8xa_: 1t8x A: [161750]
        automated match to d1pe1a_
        complexed with a5p, cd, pep, po4
      2. 2421547Domain d1t8xb_: 1t8x B: [161751]
        automated match to d1pe1a_
        complexed with a5p, cd, pep, po4
    18. Domains for 1t96:
      1. 2421554Domain d1t96a_: 1t96 A: [161753]
        automated match to d1pe1a_
        complexed with cd, pep, po4
      2. 2421555Domain d1t96b_: 1t96 B: [161754]
        automated match to d1pe1a_
        complexed with cd, pep, po4
    19. Domains for 1t99:
      1. 2421556Domain d1t99a_: 1t99 A: [161755]
        automated match to d1pe1a_
        complexed with cd, po4
      2. 2421557Domain d1t99b_: 1t99 B: [161756]
        automated match to d1pe1a_
        complexed with cd, po4
    20. Domains for 1zha:
      1. 2421588Domain d1zhaa_: 1zha A: [162477]
        automated match to d1pe1a_
        complexed with cd, pep, po4, r5p; mutant
      2. 2421589Domain d1zhab_: 1zha B: [162478]
        automated match to d1pe1a_
        complexed with cd, pep, po4, r5p; mutant
    21. Domains for 1zji:
      1. 2421590Domain d1zjia_: 1zji A: [162490]
        automated match to d1pe1a_
        complexed with 2pg, cd, po4, r5p; mutant
      2. 2421591Domain d1zjib_: 1zji B: [162491]
        automated match to d1pe1a_
        complexed with 2pg, cd, po4, r5p; mutant
    22. Domains for 2a21:
      1. 2421600Domain d2a21a_: 2a21 A: [126023]
        automated match to d1pe1a_
        complexed with pep, po4, zn
      2. 2421601Domain d2a21b_: 2a21 B: [126024]
        automated match to d1pe1a_
        complexed with pep, po4, zn
    23. Domains for 2a2i:
      1. 2421626Domain d2a2ia_: 2a2i A: [126031]
        automated match to d1pe1a_
        complexed with a5p, pep, zn
      2. 2421627Domain d2a2ib_: 2a2i B: [126032]
        automated match to d1pe1a_
        complexed with a5p, pep, zn
    24. Domains for 2nwr:
      1. 2421540Domain d2nwra_: 2nwr A: [166386]
        automated match to d1pe1a_
        complexed with pep, po4; mutant
      2. 2421541Domain d2nwrb_: 2nwr B: [166387]
        automated match to d1pe1a_
        complexed with pep, po4; mutant
    25. Domains for 2nws:
      1. 2421558Domain d2nwsa_: 2nws A: [166388]
        automated match to d1pe1a_
        complexed with a5p, pep
      2. 2421559Domain d2nwsb_: 2nws B: [166389]
        automated match to d1pe1a_
        complexed with a5p, pep
    26. Domains for 2nx1:
      1. 2421552Domain d2nx1a_: 2nx1 A: [166393]
        automated match to d1pe1a_
        complexed with pep, rp5
      2. 2421553Domain d2nx1b_: 2nx1 B: [166394]
        automated match to d1pe1a_
        complexed with pep, rp5
    27. Domains for 2nx3:
      1. 2421576Domain d2nx3a_: 2nx3 A: [166395]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
      2. 2421577Domain d2nx3b_: 2nx3 B: [166396]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
      3. 2421578Domain d2nx3c_: 2nx3 C: [166397]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
      4. 2421579Domain d2nx3d_: 2nx3 D: [166398]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
      5. 2421580Domain d2nx3e_: 2nx3 E: [166399]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
      6. 2421581Domain d2nx3f_: 2nx3 F: [166400]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
      7. 2421582Domain d2nx3g_: 2nx3 G: [166401]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
      8. 2421583Domain d2nx3h_: 2nx3 H: [166402]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
      9. 2421584Domain d2nx3i_: 2nx3 I: [166403]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
      10. 2421585Domain d2nx3j_: 2nx3 J: [166404]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
      11. 2421586Domain d2nx3k_: 2nx3 K: [166405]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
      12. 2421587Domain d2nx3l_: 2nx3 L: [166406]
        automated match to d1pe1a_
        complexed with 1nt, a5p, pep
    28. Domains for 2nxg:
      1. 2421562Domain d2nxga_: 2nxg A: [166413]
        automated match to d1fwna_
        complexed with 1nt, a5p, pep
      2. 2421563Domain d2nxgb_: 2nxg B: [166414]
        automated match to d1fwsa_
        complexed with 1nt, a5p, pep
    29. Domains for 2nxh:
      1. 2421564Domain d2nxha_: 2nxh A: [166415]
        automated match to d1fwna_
        complexed with pep, po4
      2. 2421565Domain d2nxhb_: 2nxh B: [166416]
        automated match to d1fwna_
        complexed with pep, po4
      3. 2421566Domain d2nxhc_: 2nxh C: [166417]
        automated match to d1fwna_
        complexed with pep, po4
      4. 2421567Domain d2nxhd_: 2nxh D: [166418]
        automated match to d1fwna_
        complexed with pep, po4
      5. 2421568Domain d2nxhe_: 2nxh E: [166419]
        automated match to d1fwna_
        complexed with pep, po4
      6. 2421569Domain d2nxhf_: 2nxh F: [166420]
        automated match to d1fwna_
        complexed with pep, po4
      7. 2421570Domain d2nxhg_: 2nxh G: [166421]
        automated match to d1fwna_
        complexed with pep, po4
      8. 2421571Domain d2nxhh_: 2nxh H: [166422]
        automated match to d1fwna_
        complexed with pep, po4
      9. 2421572Domain d2nxhi_: 2nxh I: [166423]
        automated match to d1fwna_
        complexed with pep, po4
      10. 2421573Domain d2nxhj_: 2nxh J: [166424]
        automated match to d1fwna_
        complexed with pep, po4
      11. 2421574Domain d2nxhk_: 2nxh K: [166425]
        automated match to d1fwna_
        complexed with pep, po4
      12. 2421575Domain d2nxhl_: 2nxh L: [166426]
        automated match to d1fwna_
        complexed with pep, po4
    30. Domains for 2nxi:
      1. 2421604Domain d2nxia_: 2nxi A: [166427]
        automated match to d1fwna_
        complexed with pep, po4
      2. 2421605Domain d2nxib_: 2nxi B: [166428]
        automated match to d1fwna_
        complexed with pep, po4
      3. 2421606Domain d2nxic_: 2nxi C: [166429]
        automated match to d1fwna_
        complexed with pep, po4
      4. 2421607Domain d2nxid_: 2nxi D: [166430]
        automated match to d1fwna_
        complexed with pep, po4
      5. 2421608Domain d2nxie_: 2nxi E: [166431]
        automated match to d1fwna_
        complexed with pep, po4
      6. 2421609Domain d2nxif_: 2nxi F: [166432]
        automated match to d1fwna_
        complexed with pep, po4
      7. 2421610Domain d2nxig_: 2nxi G: [166433]
        automated match to d1fwna_
        complexed with pep, po4
      8. 2421611Domain d2nxih_: 2nxi H: [166434]
        automated match to d1fwna_
        complexed with pep, po4
      9. 2421612Domain d2nxii_: 2nxi I: [166435]
        automated match to d1fwna_
        complexed with pep, po4
      10. 2421613Domain d2nxij_: 2nxi J: [166436]
        automated match to d1fwna_
        complexed with pep, po4
      11. 2421614Domain d2nxik_: 2nxi K: [166437]
        automated match to d1fwna_
        complexed with pep, po4
      12. 2421615Domain d2nxil_: 2nxi L: [166438]
        automated match to d1fwna_
        complexed with pep, po4
    31. Domains for 3e0i:
      1. 2421538Domain d3e0ia_: 3e0i A: [174433]
        automated match to d1pe1a_
        complexed with cu, pep, po4
      2. 2421539Domain d3e0ib_: 3e0i B: [174434]
        automated match to d1pe1a_
        complexed with cu, pep, po4
    32. Domains for 3e12:
      1. 2421542Domain d3e12a_: 3e12 A: [174445]
        automated match to d1pe1a_
        complexed with act, cu, kd0, po4
      2. 2421543Domain d3e12b_: 3e12 B: [174446]
        automated match to d1pe1a_
        complexed with act, cu, kd0, po4
  2. 2421632Escherichia coli [TaxId:562] [51603] (10 PDB entries)
    Uniprot P17579
    1. Domains for 1d9e:
      1. 2421636Domain d1d9ea_: 1d9e A: [29195]
        complexed with so4
      2. 2421637Domain d1d9eb_: 1d9e B: [29196]
        complexed with so4
      3. 2421638Domain d1d9ec_: 1d9e C: [29197]
        complexed with so4
      4. 2421639Domain d1d9ed_: 1d9e D: [29198]
        complexed with so4
    2. Domain for 1g7u:
    3. Domain for 1g7v:
    4. Domain for 1gg0:
    5. Domain for 1phq:
    6. Domain for 1phw:
    7. Domain for 1pl9:
    8. Domain for 1q3n:
    9. Domain for 1x6u:
    10. Domain for 1x8f:
  3. 2421646Haemophilus influenzae [TaxId:727] [102095] (1 PDB entry)
  4. 2421651Neisseria meningitidis [TaxId:487] [188482] (1 PDB entry)

More info for Protein 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8P synthase) from c.1.10.4: Class I DAHP synthetase

Timeline for Protein 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8P synthase) from c.1.10.4: Class I DAHP synthetase: