SCOPe 2.06: Protein: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

Lineage for Protein: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

Root: SCOPe 2.06
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites

Superfamily c.1.10: Aldolase [51569] (9 families)
Common fold covers whole protein structure
Family c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51594] (2 proteins)
hybrid of classes I and II aldolase
automatically mapped to Pfam PF00490
Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51595] (5 species)

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51596] (12 PDB entries)
1. Domain for 1aw5:
  - Domain d1aw5a_: 1aw5 A: [29181]
    complexed with zn
2. Domain for 1eb3:
  - Domain d1eb3a_: 1eb3 A: [59403]
    complexed with dsb, zn
3. Domain for 1gjp:
  - Domain d1gjpa_: 1gjp A: [60577]
    complexed with 4ox, zn
4. Domain for 1h7n:
  - Domain d1h7na_: 1h7n A: [60726]
    complexed with shf, zn
5. Domain for 1h7o:
  - Domain d1h7oa_: 1h7o A: [60727]
    complexed with dav, zn
6. Domain for 1h7p:
  - Domain d1h7pa_: 1h7p A: [60728]
    complexed with kah, zn
7. Domain for 1h7r:
  - Domain d1h7ra_: 1h7r A: [60729]
    complexed with shu, zn
8. Domain for 1ohl:
  - Domain d1ohla_: 1ohl A: [87035]
    complexed with bme, pbg, zn
9. Domain for 1qmk:
  - Domain d1qmka_: 1qmk A: [302954]
    automated match to d1h7ra_
    complexed with pb
10. Domain for 1qml:
  - Domain d1qmla_: 1qml A: [29183]
    complexed with hg
11. Domain for 1qnv:
  - Domain d1qnva_: 1qnv A: [29182]
    complexed with pb
12. Domain for 1ylv:
  - Domain d1ylva_: 1ylv A: [29180]
    complexed with shf, zn
Escherichia coli [TaxId:562] [51598] (4 PDB entries)
1. Domain for 1b4e:
  - Domain d1b4ea_: 1b4e A: [29186]
    complexed with gol, shf, so4, zn
2. Domains for 1i8j:
  1. Domain d1i8ja_: 1i8j A: [61968]
    complexed with dsb, mg, zn
  2. Domain d1i8jb_: 1i8j B: [61969]
    complexed with dsb, mg, zn
3. Domains for 1l6s:
  1. Domain d1l6sa_: 1l6s A: [73627]
    complexed with dsb, mg, zn
  2. Domain d1l6sb_: 1l6s B: [73628]
    complexed with dsb, mg, zn
4. Domains for 1l6y:
  1. Domain d1l6ya_: 1l6y A: [73645]
    complexed with 4ox, gol, mg, zn
  2. Domain d1l6yb_: 1l6y B: [73646]
    complexed with 4ox, gol, mg, zn
Human (Homo sapiens) [TaxId:9606] [63921] (4 PDB entries)
1. Domains for 1e51:
  1. Domain d1e51a_: 1e51 A: [59254]
    complexed with pbg, so4, zn
  2. Domain d1e51b_: 1e51 B: [59255]
    complexed with pbg, so4, zn
2. Domains for 1pv8:
  1. Domain d1pv8a_: 1pv8 A: [95155]
    complexed with pb1, zn; mutant
  2. Domain d1pv8b_: 1pv8 B: [95156]
    complexed with pb1, zn; mutant
3. Domains for 5hms:
  1. Domain d5hmsa_: 5hms A: [314757]
    automated match to d1e51a_
    complexed with zn
  2. Domain d5hmsb_: 5hms B: [314758]
    automated match to d1e51a_
    complexed with zn
4. Domains for 5hnr:
  1. Domain d5hnra_: 5hnr A: [314831]
    automated match to d1e51a_
    complexed with dav, so4, zn
  2. Domain d5hnrb_: 5hnr B: [314803]
    automated match to d1e51a_
    complexed with dav, so4, zn
Prosthecochloris vibrioformis [TaxId:1098] [110362] (2 PDB entries)
Uniprot Q59334
1. Domains for 1w1z:
  1. Domain d1w1za_: 1w1z A: [109081]
    complexed with mg, shf
  2. Domain d1w1zb_: 1w1z B: [109082]
    complexed with mg, shf
2. Domains for 2c1h:
  1. Domain d2c1ha_: 2c1h A: [129634]
    automated match to d1w1za_
    complexed with dsb, mg
  2. Domain d2c1hb_: 2c1h B: [129635]
    automated match to d1w1za_
    complexed with dsb, mg
Pseudomonas aeruginosa [TaxId:287] [51597] (2 PDB entries)
1. Domains for 1b4k:
  1. Domain d1b4ka_: 1b4k A: [29184]
    complexed with mg, shf, so4
  2. Domain d1b4kb_: 1b4k B: [29185]
    complexed with mg, shf, so4
2. Domains for 1gzg:
  1. Domain d1gzga_: 1gzg A: [70805]
    complexed with k, laf, mg, na, so4; mutant
  2. Domain d1gzgb_: 1gzg B: [70806]
    complexed with k, laf, mg, na, so4; mutant

More info for Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

Timeline for Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase):

Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) first appeared (with stable ids) in SCOP 1.55
Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) appears in SCOPe 2.05
Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) appears in SCOPe 2.07
Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) appears in the current release, SCOPe 2.08