Lineage for Protein: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

  1. Root: SCOP 1.71
  2. 570216Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
  3. 570217Fold c.1: TIM beta/alpha-barrel [51350] (32 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 572455Superfamily c.1.10: Aldolase [51569] (6 families) (S)
    Common fold covers whole protein structure
  5. 572777Family c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51594] (1 protein)
    hybrid of classes I and II aldolase
  6. 572778Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51595] (5 species)

Species:

  1. 572779Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51596] (11 PDB entries)
    1. Domain for 1aw5:
    2. Domain for 1eb3:
    3. Domain for 1gjp:
    4. Domain for 1h7n:
    5. Domain for 1h7o:
    6. Domain for 1h7p:
    7. Domain for 1h7r:
    8. Domain for 1ohl:
    9. Domain for 1qml:
    10. Domain for 1qnv:
    11. Domain for 1ylv:
  2. 572791Escherichia coli [TaxId:562] [51598] (4 PDB entries)
    1. Domain for 1b4e:
    2. Domains for 1i8j:
      1. 572795Domain d1i8ja_: 1i8j A: [61968]
      2. 572796Domain d1i8jb_: 1i8j B: [61969]
        complexed with dsb, mg, zn
    3. Domains for 1l6s:
      1. 572792Domain d1l6sa_: 1l6s A: [73627]
      2. 572793Domain d1l6sb_: 1l6s B: [73628]
        complexed with cme, dsb, mg, zn
    4. Domains for 1l6y:
      1. 572797Domain d1l6ya_: 1l6y A: [73645]
      2. 572798Domain d1l6yb_: 1l6y B: [73646]
        complexed with 4ox, cme, gol, mg, zn
  3. 572799Human (Homo sapiens) [TaxId:9606] [63921] (2 PDB entries)
    1. Domains for 1e51:
      1. 572802Domain d1e51a_: 1e51 A: [59254]
      2. 572803Domain d1e51b_: 1e51 B: [59255]
        complexed with pbg, so4, zn
    2. Domains for 1pv8:
      1. 572800Domain d1pv8a_: 1pv8 A: [95155]
      2. 572801Domain d1pv8b_: 1pv8 B: [95156]
        complexed with pb1, zn; mutant
  4. 572804Prosthecochloris vibrioformis [TaxId:1098] [110362] (1 PDB entry)
  5. 572807Pseudomonas aeruginosa [TaxId:287] [51597] (2 PDB entries)
    1. Domains for 1b4k:
      1. 572810Domain d1b4ka_: 1b4k A: [29184]
      2. 572811Domain d1b4kb_: 1b4k B: [29185]
        complexed with lea, mg, so4
    2. Domains for 1gzg:
      1. 572808Domain d1gzga_: 1gzg A: [70805]
      2. 572809Domain d1gzgb_: 1gzg B: [70806]
        complexed with k, laf, mg, na, so4; mutant

More info for Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

Timeline for Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase):

  • Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) first appeared (with stable ids) in SCOP 1.55
  • Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) appears in SCOP 1.69
  • Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) appears in SCOP 1.73
  • Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) appears in the current release, SCOPe 2.08