Lineage for Protein: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

  1. Root: SCOP 1.63
  2. 235644Class c: Alpha and beta proteins (a/b) [51349] (117 folds)
  3. 235645Fold c.1: TIM beta/alpha-barrel [51350] (26 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 237126Superfamily c.1.10: Aldolase [51569] (4 families) (S)
    Common fold covers whole protein structure
  5. 237313Family c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51594] (1 protein)
    hybrid of classes I and II aldolase
  6. 237314Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51595] (4 species)

Species:

  1. 237315Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51596] (10 PDB entries)
    1. Domain for 1aw5:
    2. Domain for 1eb3:
    3. Domain for 1gjp:
    4. Domain for 1h7n:
    5. Domain for 1h7o:
    6. Domain for 1h7p:
    7. Domain for 1h7r:
    8. Domain for 1qml:
    9. Domain for 1qnv:
    10. Domain for 1ylv:
  2. 237326Escherichia coli [TaxId:562] [51598] (4 PDB entries)
    1. Domain for 1b4e:
    2. Domains for 1i8j:
      1. 237330Domain d1i8ja_: 1i8j A: [61968]
      2. 237331Domain d1i8jb_: 1i8j B: [61969]
        complexed with dsb, mg, zn
    3. Domains for 1l6s:
      1. 237327Domain d1l6sa_: 1l6s A: [73627]
      2. 237328Domain d1l6sb_: 1l6s B: [73628]
        complexed with cme, dsb, mg, zn
    4. Domains for 1l6y:
      1. 237332Domain d1l6ya_: 1l6y A: [73645]
      2. 237333Domain d1l6yb_: 1l6y B: [73646]
        complexed with 4ox, cme, gol, mg, zn
  3. 237334Human (Homo sapiens) [TaxId:9606] [63921] (1 PDB entry)
  4. 237337Pseudomonas aeruginosa [TaxId:287] [51597] (2 PDB entries)
    1. Domains for 1b4k:
      1. 237340Domain d1b4ka_: 1b4k A: [29184]
      2. 237341Domain d1b4kb_: 1b4k B: [29185]
        complexed with lea, mg, so4
    2. Domains for 1gzg:
      1. 237338Domain d1gzga_: 1gzg A: [70805]
      2. 237339Domain d1gzgb_: 1gzg B: [70806]
        complexed with k, laf, mg, na, so4; mutant

More info for Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

Timeline for Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase):

  • Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) first appeared (with stable ids) in SCOP 1.55
  • Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) appears in SCOP 1.61
  • Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) appears in SCOP 1.65
  • Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) appears in the current release, SCOPe 2.08