Lineage for Protein: Fructose-1,6-bisphosphate aldolase

  1. Root: SCOPe 2.05
  2. 1815291Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1815292Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 1821671Superfamily c.1.10: Aldolase [51569] (9 families) (S)
    Common fold covers whole protein structure
  5. 1821672Family c.1.10.1: Class I aldolase [51570] (13 proteins)
    the catalytic lysine forms schiff-base intermediate with substrate
    possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels
  6. 1821887Protein Fructose-1,6-bisphosphate aldolase [51576] (11 species)

Species:

  1. 1821888Fruit fly (Drosophila melanogaster) [TaxId:7227] [51579] (1 PDB entry)
  2. 1821893Human (Homo sapiens) [TaxId:9606] [254964] (2 PDB entries)
    1. Domains for 1xdl:
      1. 1821902Domain d1xdlb_: 1xdl B: [121873]
        automated match to d1fdja_
        complexed with so4
      2. 1821903Domain d1xdlc_: 1xdl C: [121874]
        automated match to d1fdja_
        complexed with so4
      3. 1821904Domain d1xdld_: 1xdl D: [121875]
        automated match to d1fdja_
        complexed with so4
      4. 1821905Domain d1xdlw_: 1xdl W: [121876]
        automated match to d1fdja_
        complexed with so4
      5. 1821906Domain d1xdlx_: 1xdl X: [121877]
        automated match to d1fdja_
        complexed with so4
      6. 1821907Domain d1xdly_: 1xdl Y: [121878]
        automated match to d1fdja_
        complexed with so4
      7. 1821908Domain d1xdlz_: 1xdl Z: [121879]
        automated match to d1fdja_
        complexed with so4
    2. Domains for 1xdm:
      1. 1821894Domain d1xdma_: 1xdm A: [121880]
        automated match to d1fdja_
        complexed with so4
      2. 1821895Domain d1xdmb_: 1xdm B: [121881]
        automated match to d1fdja_
        complexed with so4
      3. 1821896Domain d1xdmc_: 1xdm C: [121882]
        automated match to d1fdja_
        complexed with so4
      4. 1821897Domain d1xdmd_: 1xdm D: [121883]
        automated match to d1fdja_
        complexed with so4
      5. 1821898Domain d1xdmw_: 1xdm W: [121884]
        automated match to d1fdja_
        complexed with so4
      6. 1821899Domain d1xdmx_: 1xdm X: [121885]
        automated match to d1fdja_
        complexed with so4
      7. 1821900Domain d1xdmy_: 1xdm Y: [121886]
        automated match to d1fdja_
        complexed with so4
      8. 1821901Domain d1xdmz_: 1xdm Z: [121887]
        automated match to d1fdja_
        complexed with so4
  3. 1821909Human (Homo sapiens), brain isozyme [TaxId:9606] [141834] (1 PDB entry)
    Uniprot P09972 2-343
  4. 1821911Human (Homo sapiens), liver isozyme [TaxId:9606] [51578] (2 PDB entries)
    1. Domains for 1qo5:
      1. 1821912Domain d1qo5a_: 1qo5 A: [29102]
        complexed with so4
      2. 1821913Domain d1qo5b_: 1qo5 B: [29103]
        complexed with so4
      3. 1821914Domain d1qo5c_: 1qo5 C: [29104]
        complexed with so4
      4. 1821915Domain d1qo5d_: 1qo5 D: [29105]
        complexed with so4
      5. 1821916Domain d1qo5e_: 1qo5 E: [29106]
        complexed with so4
      6. 1821917Domain d1qo5f_: 1qo5 F: [29107]
        complexed with so4
      7. 1821918Domain d1qo5g_: 1qo5 G: [29108]
        complexed with so4
      8. 1821919Domain d1qo5h_: 1qo5 H: [29109]
        complexed with so4
      9. 1821920Domain d1qo5i_: 1qo5 I: [29110]
        complexed with so4
      10. 1821921Domain d1qo5j_: 1qo5 J: [29111]
        complexed with so4
      11. 1821922Domain d1qo5k_: 1qo5 K: [29112]
        complexed with so4
      12. 1821923Domain d1qo5l_: 1qo5 L: [29113]
        complexed with so4
      13. 1821924Domain d1qo5m_: 1qo5 M: [29114]
        complexed with so4
      14. 1821925Domain d1qo5n_: 1qo5 N: [29115]
        complexed with so4
      15. 1821926Domain d1qo5o_: 1qo5 O: [29116]
        complexed with so4
      16. 1821927Domain d1qo5p_: 1qo5 P: [29117]
        complexed with so4
      17. 1821928Domain d1qo5q_: 1qo5 Q: [29118]
        complexed with so4
      18. 1821929Domain d1qo5r_: 1qo5 R: [29119]
        complexed with so4
    2. Domain for 1xdl:
  5. 1821931Human (Homo sapiens), muscle isozyme [TaxId:9606] [51577] (3 PDB entries)
    1. Domain for 1ald:
    2. Domain for 2ald:
    3. Domain for 4ald:
  6. 1821935Malaria parasite (Plasmodium falciparum) [TaxId:5833] [51581] (1 PDB entry)
  7. 1821938Plasmodium yoelii yoelii [TaxId:73239] [141833] (1 PDB entry)
    Uniprot Q7RMC9 3-258
  8. 1821941Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId:9986] [63920] (1 PDB entry)
  9. 1821946Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId:9986] [51580] (25 PDB entries)
    1. Domains for 1ado:
      1. 1821976Domain d1adoa_: 1ado A: [29124]
        complexed with 13p, so4
      2. 1821977Domain d1adob_: 1ado B: [29125]
        complexed with 13p, so4
      3. 1821978Domain d1adoc_: 1ado C: [29126]
        complexed with 13p, so4
      4. 1821979Domain d1adod_: 1ado D: [29127]
        complexed with 13p, so4
    2. Domains for 1ewd:
      1. 1822028Domain d1ewda_: 1ewd A: [29132]
      2. 1822029Domain d1ewdb_: 1ewd B: [29133]
      3. 1822030Domain d1ewdc_: 1ewd C: [29134]
      4. 1822031Domain d1ewdd_: 1ewd D: [29135]
    3. Domains for 1ewe:
      1. 1822032Domain d1ewea_: 1ewe A: [29136]
        complexed with so4
      2. 1822033Domain d1eweb_: 1ewe B: [29137]
        complexed with so4
      3. 1822034Domain d1ewec_: 1ewe C: [29138]
        complexed with so4
      4. 1822035Domain d1ewed_: 1ewe D: [29139]
        complexed with so4
    4. Domains for 1ex5:
      1. 1822024Domain d1ex5a_: 1ex5 A: [29140]
      2. 1822025Domain d1ex5b_: 1ex5 B: [29141]
      3. 1822026Domain d1ex5c_: 1ex5 C: [29142]
      4. 1822027Domain d1ex5d_: 1ex5 D: [29143]
    5. Domains for 1j4e:
      1. 1822040Domain d1j4ea_: 1j4e A: [66375]
        complexed with 13p
      2. 1822041Domain d1j4eb_: 1j4e B: [66376]
        complexed with 13p
      3. 1822042Domain d1j4ec_: 1j4e C: [66377]
        complexed with 13p
      4. 1822043Domain d1j4ed_: 1j4e D: [66378]
        complexed with 13p
    6. Domains for 1zah:
      1. 1821960Domain d1zaha1: 1zah A:1-363 [124824]
      2. 1821961Domain d1zahb_: 1zah B: [124825]
        automated match to d1adoa_
      3. 1821962Domain d1zahc_: 1zah C: [124826]
        automated match to d1adoa_
      4. 1821963Domain d1zahd_: 1zah D: [124827]
        automated match to d1adoa_
    7. Domains for 1zai:
      1. 1821948Domain d1zaia_: 1zai A: [124828]
        automated match to d1adoa_
        complexed with 2fp
      2. 1821949Domain d1zaib_: 1zai B: [124829]
        automated match to d1adoa_
        complexed with 2fp
      3. 1821950Domain d1zaic_: 1zai C: [124830]
        automated match to d1adoa_
        complexed with 2fp
      4. 1821951Domain d1zaid_: 1zai D: [124831]
        automated match to d1adoa_
        complexed with 2fp
    8. Domains for 1zaj:
      1. 1821980Domain d1zaja_: 1zaj A: [124832]
        automated match to d1adoa_
        complexed with m2p
      2. 1821981Domain d1zajb_: 1zaj B: [124833]
        automated match to d1adoa_
        complexed with m2p
      3. 1821982Domain d1zajc_: 1zaj C: [124834]
        automated match to d1adoa_
        complexed with m2p
      4. 1821983Domain d1zajd_: 1zaj D: [124835]
        automated match to d1adoa_
        complexed with m2p
    9. Domains for 1zal:
      1. 1821984Domain d1zala_: 1zal A: [124836]
        automated match to d1adoa_
        complexed with po4
      2. 1821985Domain d1zalb_: 1zal B: [124837]
        automated match to d1adoa_
        complexed with po4
      3. 1821986Domain d1zalc_: 1zal C: [124838]
        automated match to d1adoa_
        complexed with po4
      4. 1821987Domain d1zald_: 1zal D: [124839]
        automated match to d1adoa_
        complexed with po4
    10. Domains for 2ot0:
      1. 1822008Domain d2ot0a_: 2ot0 A: [139303]
        automated match to d1adoa_
      2. 1822009Domain d2ot0b_: 2ot0 B: [139304]
        automated match to d1adoa_
      3. 1822010Domain d2ot0c_: 2ot0 C: [139305]
        automated match to d1adoa_
      4. 1822011Domain d2ot0d_: 2ot0 D: [139306]
        automated match to d1adoa_
    11. Domains for 2ot1:
      1. 1822000Domain d2ot1a_: 2ot1 A: [139307]
        automated match to d1adoa_
        complexed with n3p
      2. 1822001Domain d2ot1b_: 2ot1 B: [139308]
        automated match to d1adoa_
        complexed with n3p
      3. 1822002Domain d2ot1c_: 2ot1 C: [139309]
        automated match to d1adoa_
        complexed with n3p
      4. 1822003Domain d2ot1d_: 2ot1 D: [139310]
        automated match to d1adoa_
        complexed with n3p
    12. Domains for 2qut:
      1. 1821964Domain d2quta_: 2qut A: [151376]
        automated match to d1adoa_
        complexed with 13p
      2. 1821965Domain d2qutb_: 2qut B: [151377]
        automated match to d1adoa_
        complexed with 13p
      3. 1821966Domain d2qutc_: 2qut C: [151378]
        automated match to d1adoa_
        complexed with 13p
      4. 1821967Domain d2qutd_: 2qut D: [151379]
        automated match to d1adoa_
        complexed with 13p
    13. Domains for 2quu:
      1. 1821992Domain d2quua_: 2quu A: [167814]
        automated match to d1adoa_
        complexed with 13p; mutant
      2. 1821993Domain d2quub_: 2quu B: [167815]
        automated match to d1adoa_
        complexed with 13p; mutant
      3. 1821994Domain d2quuc_: 2quu C: [167816]
        automated match to d1adoa_
        complexed with 13p; mutant
      4. 1821995Domain d2quud_: 2quu D: [167817]
        automated match to d1adoa_
        complexed with 13p; mutant
    14. Domains for 2quv:
      1. 1822012Domain d2quva_: 2quv A: [151380]
        automated match to d1adoa_
        complexed with po4
      2. 1822013Domain d2quvb_: 2quv B: [151381]
        automated match to d1adoa_
        complexed with po4
      3. 1822014Domain d2quvc_: 2quv C: [151382]
        automated match to d1adoa_
        complexed with po4
      4. 1822015Domain d2quvd_: 2quv D: [151383]
        automated match to d1adoa_
        complexed with po4
    15. Domains for 3b8d:
      1. 1822020Domain d3b8da_: 3b8d A: [154951]
        automated match to d1adoa_
        complexed with so4
      2. 1822021Domain d3b8db_: 3b8d B: [154952]
        automated match to d1adoa_
        complexed with so4
      3. 1822022Domain d3b8dc_: 3b8d C: [154953]
        automated match to d1adoa_
        complexed with so4
      4. 1822023Domain d3b8dd_: 3b8d D: [154954]
        automated match to d1adoa_
        complexed with so4
    16. Domain for 3bv4:
    17. Domains for 3dfn:
      1. 1821956Domain d3dfna_: 3dfn A: [173892]
        automated match to d1adoa_
        mutant
      2. 1821957Domain d3dfnb_: 3dfn B: [173893]
        automated match to d1adoa_
        mutant
      3. 1821958Domain d3dfnc_: 3dfn C: [173894]
        automated match to d1adoa_
        mutant
      4. 1821959Domain d3dfnd_: 3dfn D: [173895]
        automated match to d1adoa_
        mutant
    18. Domains for 3dfo:
      1. 1821972Domain d3dfoa_: 3dfo A: [173896]
        automated match to d1adoa_
        complexed with 13p; mutant
      2. 1821973Domain d3dfob_: 3dfo B: [173897]
        automated match to d1adoa_
        complexed with 13p; mutant
      3. 1821974Domain d3dfoc_: 3dfo C: [173898]
        automated match to d1adoa_
        complexed with 13p; mutant
      4. 1821975Domain d3dfod_: 3dfo D: [173899]
        automated match to d1adoa_
        complexed with 13p; mutant
    19. Domains for 3dfp:
      1. 1821996Domain d3dfpa_: 3dfp A: [173900]
        automated match to d1adoa_
        complexed with po4; mutant
      2. 1821997Domain d3dfpb_: 3dfp B: [173901]
        automated match to d1adoa_
        complexed with po4; mutant
      3. 1821998Domain d3dfpc_: 3dfp C: [173902]
        automated match to d1adoa_
        complexed with po4; mutant
      4. 1821999Domain d3dfpd_: 3dfp D: [173903]
        automated match to d1adoa_
        complexed with po4; mutant
    20. Domains for 3dfq:
      1. 1821952Domain d3dfqa_: 3dfq A: [173904]
        automated match to d1adoa_
        mutant
      2. 1821953Domain d3dfqb_: 3dfq B: [173905]
        automated match to d1adoa_
        mutant
      3. 1821954Domain d3dfqc_: 3dfq C: [173906]
        automated match to d1adoa_
        mutant
      4. 1821955Domain d3dfqd_: 3dfq D: [173907]
        automated match to d1adoa_
        mutant
    21. Domains for 3dfs:
      1. 1821988Domain d3dfsa_: 3dfs A: [173908]
        automated match to d1adoa_
        complexed with 13p; mutant
      2. 1821989Domain d3dfsb_: 3dfs B: [173909]
        automated match to d1adoa_
        complexed with 13p; mutant
      3. 1821990Domain d3dfsc_: 3dfs C: [173910]
        automated match to d1adoa_
        complexed with 13p; mutant
      4. 1821991Domain d3dfsd_: 3dfs D: [173911]
        automated match to d1adoa_
        complexed with 13p; mutant
    22. Domains for 3dft:
      1. 1821968Domain d3dfta_: 3dft A: [173912]
        automated match to d1adoa_
        complexed with po4; mutant
      2. 1821969Domain d3dftb_: 3dft B: [173913]
        automated match to d1adoa_
        complexed with po4; mutant
      3. 1821970Domain d3dftc_: 3dft C: [173914]
        automated match to d1adoa_
        complexed with po4; mutant
      4. 1821971Domain d3dftd_: 3dft D: [173915]
        automated match to d1adoa_
        complexed with po4; mutant
    23. Domains for 3lge:
      1. 1822016Domain d3lgea_: 3lge A: [180274]
        automated match to d1adoa_
      2. 1822017Domain d3lgeb_: 3lge B: [180275]
        automated match to d1adoa_
      3. 1822018Domain d3lgec_: 3lge C: [180276]
        automated match to d1adoa_
      4. 1822019Domain d3lged_: 3lge D: [180277]
        automated match to d1adoa_
    24. Domains for 3tu9:
      1. 1822004Domain d3tu9a_: 3tu9 A: [185952]
        automated match to d1adoa_
        complexed with 5mm
      2. 1822005Domain d3tu9b_: 3tu9 B: [185953]
        automated match to d1adoa_
        complexed with 5mm
      3. 1822006Domain d3tu9c_: 3tu9 C: [185954]
        automated match to d1adoa_
        complexed with 5mm
      4. 1822007Domain d3tu9d_: 3tu9 D: [185955]
        automated match to d1adoa_
        complexed with 5mm
    25. Domains for 6ald:
      1. 1822036Domain d6alda_: 6ald A: [29144]
        complexed with 2fp
      2. 1822037Domain d6aldb_: 6ald B: [29145]
        complexed with 2fp
      3. 1822038Domain d6aldc_: 6ald C: [29146]
        complexed with 2fp
      4. 1822039Domain d6aldd_: 6ald D: [29147]
        complexed with 2fp
  10. Trypanosome (Leishmania mexicana) [TaxId:5665] [51582] (1 PDB entry)
  11. 1822049Trypanosome (Trypanosoma brucei) [TaxId:5691] [51583] (1 PDB entry)

More info for Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase

Timeline for Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase: