Lineage for Protein: Fructose-1,6-bisphosphate aldolase

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 968086Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 972170Superfamily c.1.10: Aldolase [51569] (9 families) (S)
    Common fold covers whole protein structure
  5. 972171Family c.1.10.1: Class I aldolase [51570] (13 proteins)
    the catalytic lysine forms schiff-base intermediate with substrate
    possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels
  6. 972386Protein Fructose-1,6-bisphosphate aldolase [51576] (10 species)

Species:

  1. 972387Fruit fly (Drosophila melanogaster) [TaxId:7227] [51579] (1 PDB entry)
  2. 972392Human (Homo sapiens), brain isozyme [TaxId:9606] [141834] (1 PDB entry)
    Uniprot P09972 2-343
  3. 972405Human (Homo sapiens), liver isozyme [TaxId:9606] [51578] (3 PDB entries)
    1. Domains for 1qo5:
      1. 972406Domain d1qo5a_: 1qo5 A: [29102]
        complexed with so4
      2. 972407Domain d1qo5b_: 1qo5 B: [29103]
        complexed with so4
      3. 972408Domain d1qo5c_: 1qo5 C: [29104]
        complexed with so4
      4. 972409Domain d1qo5d_: 1qo5 D: [29105]
        complexed with so4
      5. 972410Domain d1qo5e_: 1qo5 E: [29106]
        complexed with so4
      6. 972411Domain d1qo5f_: 1qo5 F: [29107]
        complexed with so4
      7. 972412Domain d1qo5g_: 1qo5 G: [29108]
        complexed with so4
      8. 972413Domain d1qo5h_: 1qo5 H: [29109]
        complexed with so4
      9. 972414Domain d1qo5i_: 1qo5 I: [29110]
        complexed with so4
      10. 972415Domain d1qo5j_: 1qo5 J: [29111]
        complexed with so4
      11. 972416Domain d1qo5k_: 1qo5 K: [29112]
        complexed with so4
      12. 972417Domain d1qo5l_: 1qo5 L: [29113]
        complexed with so4
      13. 972418Domain d1qo5m_: 1qo5 M: [29114]
        complexed with so4
      14. 972419Domain d1qo5n_: 1qo5 N: [29115]
        complexed with so4
      15. 972420Domain d1qo5o_: 1qo5 O: [29116]
        complexed with so4
      16. 972421Domain d1qo5p_: 1qo5 P: [29117]
        complexed with so4
      17. 972422Domain d1qo5q_: 1qo5 Q: [29118]
        complexed with so4
      18. 972423Domain d1qo5r_: 1qo5 R: [29119]
        complexed with so4
    2. Domains for 1xdl:
      1. 972432Domain d1xdla1: 1xdl A:6-343 [121872]
        complexed with so4
      2. 972433Domain d1xdlb1: 1xdl B:6-343 [121873]
        automatically matched to 1XDL A:6-343
        complexed with so4
      3. 972434Domain d1xdlc1: 1xdl C:6-343 [121874]
        automatically matched to 1XDL A:6-343
        complexed with so4
      4. 972435Domain d1xdld1: 1xdl D:6-343 [121875]
        automatically matched to 1XDL A:6-343
        complexed with so4
      5. 972436Domain d1xdlw1: 1xdl W:6-343 [121876]
        automatically matched to 1XDL A:6-343
        complexed with so4
      6. 972437Domain d1xdlx1: 1xdl X:6-343 [121877]
        automatically matched to 1XDL A:6-343
        complexed with so4
      7. 972438Domain d1xdly1: 1xdl Y:6-343 [121878]
        automatically matched to 1XDL A:6-343
        complexed with so4
      8. 972439Domain d1xdlz1: 1xdl Z:6-342 [121879]
        automatically matched to 1XDL A:6-343
        complexed with so4
    3. Domains for 1xdm:
      1. 972424Domain d1xdma1: 1xdm A:6-342 [121880]
        automatically matched to 1XDL A:6-343
        complexed with so4
      2. 972425Domain d1xdmb1: 1xdm B:6-343 [121881]
        automatically matched to 1XDL A:6-343
        complexed with so4
      3. 972426Domain d1xdmc1: 1xdm C:6-343 [121882]
        automatically matched to 1XDL A:6-343
        complexed with so4
      4. 972427Domain d1xdmd1: 1xdm D:6-342 [121883]
        automatically matched to 1XDL A:6-343
        complexed with so4
      5. 972428Domain d1xdmw1: 1xdm W:6-343 [121884]
        automatically matched to 1XDL A:6-343
        complexed with so4
      6. 972429Domain d1xdmx1: 1xdm X:6-343 [121885]
        automatically matched to 1XDL A:6-343
        complexed with so4
      7. 972430Domain d1xdmy1: 1xdm Y:6-343 [121886]
        automatically matched to 1XDL A:6-343
        complexed with so4
      8. 972431Domain d1xdmz1: 1xdm Z:6-342 [121887]
        automatically matched to 1XDL A:6-343
        complexed with so4
  4. 972440Human (Homo sapiens), muscle isozyme [TaxId:9606] [51577] (3 PDB entries)
    1. Domain for 1ald:
    2. Domain for 2ald:
    3. Domain for 4ald:
  5. 972444Malaria parasite (Plasmodium falciparum) [TaxId:5833] [51581] (1 PDB entry)
  6. 972447Plasmodium yoelii yoelii [TaxId:73239] [141833] (1 PDB entry)
    Uniprot Q7RMC9 3-258
  7. 972450Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId:9986] [63920] (1 PDB entry)
  8. 972455Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId:9986] [51580] (24 PDB entries)
    1. Domains for 1ado:
      1. 972484Domain d1adoa_: 1ado A: [29124]
        complexed with 13p, so4
      2. 972485Domain d1adob_: 1ado B: [29125]
        complexed with 13p, so4
      3. 972486Domain d1adoc_: 1ado C: [29126]
        complexed with 13p, so4
      4. 972487Domain d1adod_: 1ado D: [29127]
        complexed with 13p, so4
    2. Domains for 1ewd:
      1. 972536Domain d1ewda_: 1ewd A: [29132]
      2. 972537Domain d1ewdb_: 1ewd B: [29133]
      3. 972538Domain d1ewdc_: 1ewd C: [29134]
      4. 972539Domain d1ewdd_: 1ewd D: [29135]
    3. Domains for 1ewe:
      1. 972540Domain d1ewea_: 1ewe A: [29136]
        complexed with so4
      2. 972541Domain d1eweb_: 1ewe B: [29137]
        complexed with so4
      3. 972542Domain d1ewec_: 1ewe C: [29138]
        complexed with so4
      4. 972543Domain d1ewed_: 1ewe D: [29139]
        complexed with so4
    4. Domains for 1ex5:
      1. 972532Domain d1ex5a_: 1ex5 A: [29140]
      2. 972533Domain d1ex5b_: 1ex5 B: [29141]
      3. 972534Domain d1ex5c_: 1ex5 C: [29142]
      4. 972535Domain d1ex5d_: 1ex5 D: [29143]
    5. Domains for 1j4e:
      1. 972548Domain d1j4ea_: 1j4e A: [66375]
        complexed with 13p
      2. 972549Domain d1j4eb_: 1j4e B: [66376]
        complexed with 13p
      3. 972550Domain d1j4ec_: 1j4e C: [66377]
        complexed with 13p
      4. 972551Domain d1j4ed_: 1j4e D: [66378]
        complexed with 13p
    6. Domains for 1zah:
      1. 972468Domain d1zaha1: 1zah A:1-363 [124824]
      2. 972469Domain d1zahb_: 1zah B: [124825]
        automated match to d1adoa_
      3. 972470Domain d1zahc_: 1zah C: [124826]
        automated match to d1adoa_
      4. 972471Domain d1zahd_: 1zah D: [124827]
        automated match to d1adoa_
    7. Domains for 1zai:
      1. 972456Domain d1zaia_: 1zai A: [124828]
        automated match to d1adoa_
        complexed with 2fp
      2. 972457Domain d1zaib_: 1zai B: [124829]
        automated match to d1adoa_
        complexed with 2fp
      3. 972458Domain d1zaic_: 1zai C: [124830]
        automated match to d1adoa_
        complexed with 2fp
      4. 972459Domain d1zaid_: 1zai D: [124831]
        automated match to d1adoa_
        complexed with 2fp
    8. Domains for 1zaj:
      1. 972488Domain d1zaja_: 1zaj A: [124832]
        automated match to d1adoa_
        complexed with m2p
      2. 972489Domain d1zajb_: 1zaj B: [124833]
        automated match to d1adoa_
        complexed with m2p
      3. 972490Domain d1zajc_: 1zaj C: [124834]
        automated match to d1adoa_
        complexed with m2p
      4. 972491Domain d1zajd_: 1zaj D: [124835]
        automated match to d1adoa_
        complexed with m2p
    9. Domains for 1zal:
      1. 972492Domain d1zala_: 1zal A: [124836]
        automated match to d1adoa_
        complexed with po4
      2. 972493Domain d1zalb_: 1zal B: [124837]
        automated match to d1adoa_
        complexed with po4
      3. 972494Domain d1zalc_: 1zal C: [124838]
        automated match to d1adoa_
        complexed with po4
      4. 972495Domain d1zald_: 1zal D: [124839]
        automated match to d1adoa_
        complexed with po4
    10. Domains for 2ot0:
      1. 972516Domain d2ot0a_: 2ot0 A: [139303]
        automated match to d1adoa_
      2. 972517Domain d2ot0b_: 2ot0 B: [139304]
        automated match to d1adoa_
      3. 972518Domain d2ot0c_: 2ot0 C: [139305]
        automated match to d1adoa_
      4. 972519Domain d2ot0d_: 2ot0 D: [139306]
        automated match to d1adoa_
    11. Domains for 2ot1:
      1. 972508Domain d2ot1a_: 2ot1 A: [139307]
        automated match to d1adoa_
        complexed with n3p
      2. 972509Domain d2ot1b_: 2ot1 B: [139308]
        automated match to d1adoa_
        complexed with n3p
      3. 972510Domain d2ot1c_: 2ot1 C: [139309]
        automated match to d1adoa_
        complexed with n3p
      4. 972511Domain d2ot1d_: 2ot1 D: [139310]
        automated match to d1adoa_
        complexed with n3p
    12. Domains for 2qut:
      1. 972472Domain d2quta_: 2qut A: [151376]
        automated match to d1adoa_
        complexed with 13p
      2. 972473Domain d2qutb_: 2qut B: [151377]
        automated match to d1adoa_
        complexed with 13p
      3. 972474Domain d2qutc_: 2qut C: [151378]
        automated match to d1adoa_
        complexed with 13p
      4. 972475Domain d2qutd_: 2qut D: [151379]
        automated match to d1adoa_
        complexed with 13p
    13. Domains for 2quu:
      1. 972500Domain d2quua_: 2quu A: [167814]
        automated match to d1adoa_
        complexed with 13p; mutant
      2. 972501Domain d2quub_: 2quu B: [167815]
        automated match to d1adoa_
        complexed with 13p; mutant
      3. 972502Domain d2quuc_: 2quu C: [167816]
        automated match to d1adoa_
        complexed with 13p; mutant
      4. 972503Domain d2quud_: 2quu D: [167817]
        automated match to d1adoa_
        complexed with 13p; mutant
    14. Domains for 2quv:
      1. 972520Domain d2quva_: 2quv A: [151380]
        automated match to d1adoa_
        complexed with po4
      2. 972521Domain d2quvb_: 2quv B: [151381]
        automated match to d1adoa_
        complexed with po4
      3. 972522Domain d2quvc_: 2quv C: [151382]
        automated match to d1adoa_
        complexed with po4
      4. 972523Domain d2quvd_: 2quv D: [151383]
        automated match to d1adoa_
        complexed with po4
    15. Domains for 3b8d:
      1. 972528Domain d3b8da_: 3b8d A: [154951]
        automated match to d1adoa_
        complexed with so4
      2. 972529Domain d3b8db_: 3b8d B: [154952]
        automated match to d1adoa_
        complexed with so4
      3. 972530Domain d3b8dc_: 3b8d C: [154953]
        automated match to d1adoa_
        complexed with so4
      4. 972531Domain d3b8dd_: 3b8d D: [154954]
        automated match to d1adoa_
        complexed with so4
    16. Domains for 3dfn:
      1. 972464Domain d3dfna_: 3dfn A: [173892]
        automated match to d1adoa_
        mutant
      2. 972465Domain d3dfnb_: 3dfn B: [173893]
        automated match to d1adoa_
        mutant
      3. 972466Domain d3dfnc_: 3dfn C: [173894]
        automated match to d1adoa_
        mutant
      4. 972467Domain d3dfnd_: 3dfn D: [173895]
        automated match to d1adoa_
        mutant
    17. Domains for 3dfo:
      1. 972480Domain d3dfoa_: 3dfo A: [173896]
        automated match to d1adoa_
        complexed with 13p; mutant
      2. 972481Domain d3dfob_: 3dfo B: [173897]
        automated match to d1adoa_
        complexed with 13p; mutant
      3. 972482Domain d3dfoc_: 3dfo C: [173898]
        automated match to d1adoa_
        complexed with 13p; mutant
      4. 972483Domain d3dfod_: 3dfo D: [173899]
        automated match to d1adoa_
        complexed with 13p; mutant
    18. Domains for 3dfp:
      1. 972504Domain d3dfpa_: 3dfp A: [173900]
        automated match to d1adoa_
        complexed with po4; mutant
      2. 972505Domain d3dfpb_: 3dfp B: [173901]
        automated match to d1adoa_
        complexed with po4; mutant
      3. 972506Domain d3dfpc_: 3dfp C: [173902]
        automated match to d1adoa_
        complexed with po4; mutant
      4. 972507Domain d3dfpd_: 3dfp D: [173903]
        automated match to d1adoa_
        complexed with po4; mutant
    19. Domains for 3dfq:
      1. 972460Domain d3dfqa_: 3dfq A: [173904]
        automated match to d1adoa_
        mutant
      2. 972461Domain d3dfqb_: 3dfq B: [173905]
        automated match to d1adoa_
        mutant
      3. 972462Domain d3dfqc_: 3dfq C: [173906]
        automated match to d1adoa_
        mutant
      4. 972463Domain d3dfqd_: 3dfq D: [173907]
        automated match to d1adoa_
        mutant
    20. Domains for 3dfs:
      1. 972496Domain d3dfsa_: 3dfs A: [173908]
        automated match to d1adoa_
        complexed with 13p; mutant
      2. 972497Domain d3dfsb_: 3dfs B: [173909]
        automated match to d1adoa_
        complexed with 13p; mutant
      3. 972498Domain d3dfsc_: 3dfs C: [173910]
        automated match to d1adoa_
        complexed with 13p; mutant
      4. 972499Domain d3dfsd_: 3dfs D: [173911]
        automated match to d1adoa_
        complexed with 13p; mutant
    21. Domains for 3dft:
      1. 972476Domain d3dfta_: 3dft A: [173912]
        automated match to d1adoa_
        complexed with po4; mutant
      2. 972477Domain d3dftb_: 3dft B: [173913]
        automated match to d1adoa_
        complexed with po4; mutant
      3. 972478Domain d3dftc_: 3dft C: [173914]
        automated match to d1adoa_
        complexed with po4; mutant
      4. 972479Domain d3dftd_: 3dft D: [173915]
        automated match to d1adoa_
        complexed with po4; mutant
    22. Domains for 3lge:
      1. 972524Domain d3lgea_: 3lge A: [180274]
        automated match to d1adoa_
      2. 972525Domain d3lgeb_: 3lge B: [180275]
        automated match to d1adoa_
      3. 972526Domain d3lgec_: 3lge C: [180276]
        automated match to d1adoa_
      4. 972527Domain d3lged_: 3lge D: [180277]
        automated match to d1adoa_
    23. Domains for 3tu9:
      1. 972512Domain d3tu9a_: 3tu9 A: [185952]
        automated match to d1adoa_
        complexed with 5mm
      2. 972513Domain d3tu9b_: 3tu9 B: [185953]
        automated match to d1adoa_
        complexed with 5mm
      3. 972514Domain d3tu9c_: 3tu9 C: [185954]
        automated match to d1adoa_
        complexed with 5mm
      4. 972515Domain d3tu9d_: 3tu9 D: [185955]
        automated match to d1adoa_
        complexed with 5mm
    24. Domains for 6ald:
      1. 972544Domain d6alda_: 6ald A: [29144]
        complexed with 2fp
      2. 972545Domain d6aldb_: 6ald B: [29145]
        complexed with 2fp
      3. 972546Domain d6aldc_: 6ald C: [29146]
        complexed with 2fp
      4. 972547Domain d6aldd_: 6ald D: [29147]
        complexed with 2fp
  9. 972552Trypanosome (Leishmania mexicana) [TaxId:5665] [51582] (4 PDB entries)
    1. Domains for 1epx:
      1. 972557Domain d1epxa_: 1epx A: [29150]
      2. 972558Domain d1epxb_: 1epx B: [29151]
      3. 972559Domain d1epxc_: 1epx C: [29152]
      4. 972560Domain d1epxd_: 1epx D: [29153]
    2. Domains for 2qap:
      1. 972553Domain d2qapa1: 2qap A:1-357 [150320]
        automatically matched to d1epxa_
        complexed with po4
      2. 972554Domain d2qapb1: 2qap B:1-357 [150321]
        automatically matched to d1epxa_
        complexed with po4
      3. 972555Domain d2qapc1: 2qap C:1-357 [150322]
        automatically matched to d1epxa_
        complexed with po4
      4. 972556Domain d2qapd1: 2qap D:1-357 [150323]
        automatically matched to d1epxa_
        complexed with po4
    3. Domains for 2qdg:
      1. 972565Domain d2qdga1: 2qdg A:1-357 [150662]
        automatically matched to d1epxa_
        complexed with 2fp, po4
      2. 972566Domain d2qdgb1: 2qdg B:1-357 [150663]
        automatically matched to d1epxa_
        complexed with 2fp, po4
      3. 972567Domain d2qdgc1: 2qdg C:1-357 [150664]
        automatically matched to d1epxa_
        complexed with 2fp, po4
      4. 972568Domain d2qdgd1: 2qdg D:1-357 [150665]
        automatically matched to d1epxa_
        complexed with 2fp, po4
    4. Domains for 2qdh:
      1. 972561Domain d2qdha1: 2qdh A:1-357 [150666]
        automatically matched to d1epxa_
        complexed with m2p
      2. 972562Domain d2qdhb1: 2qdh B:1-357 [150667]
        automatically matched to d1epxa_
        complexed with m2p
      3. 972563Domain d2qdhc1: 2qdh C:1-357 [150668]
        automatically matched to d1epxa_
        complexed with m2p
      4. 972564Domain d2qdhd1: 2qdh D:1-357 [150669]
        automatically matched to d1epxa_
        complexed with m2p
  10. 972569Trypanosome (Trypanosoma brucei) [TaxId:5691] [51583] (1 PDB entry)

More info for Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase

Timeline for Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase: