SCOP 1.73: Protein: Fructose-1,6-bisphosphate aldolase

Lineage for Protein: Fructose-1,6-bisphosphate aldolase

Root: SCOP 1.73
Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites

Superfamily c.1.10: Aldolase [51569] (8 families)
Common fold covers whole protein structure

Family c.1.10.1: Class I aldolase [51570] (12 proteins)
the catalytic lysine forms schiff-base intermediate with substrate
possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels

Protein Fructose-1,6-bisphosphate aldolase [51576] (10 species)

Species:

Drosophila melanogaster [TaxId:7227] [51579] (1 PDB entry)
- Domains for 1fba:
  1. Domain d1fbaa_: 1fba A: [29120]
  2. Domain d1fbab_: 1fba B: [29121]
  3. Domain d1fbac_: 1fba C: [29122]
  4. Domain d1fbad_: 1fba D: [29123]
Human (Homo sapiens), brain isozyme [TaxId:9606] [141834] (1 PDB entry)
- Domains for 1xfb:
  1. Domain d1xfba1: 1xfb A:3-344 [121922]
  2. Domain d1xfbb1: 1xfb B:3-344 [121923]
    automatically matched to 1XFB A:3-344
  3. Domain d1xfbc1: 1xfb C:3-344 [121924]
    automatically matched to 1XFB A:3-344
  4. Domain d1xfbd1: 1xfb D:3-344 [121925]
    automatically matched to 1XFB A:3-344
  5. Domain d1xfbe1: 1xfb E:3-344 [121926]
    automatically matched to 1XFB A:3-344
  6. Domain d1xfbf1: 1xfb F:3-344 [121927]
    automatically matched to 1XFB A:3-344
  7. Domain d1xfbg1: 1xfb G:3-344 [121928]
    automatically matched to 1XFB A:3-344
  8. Domain d1xfbh1: 1xfb H:3-344 [121929]
    automatically matched to 1XFB A:3-344
  9. Domain d1xfbi1: 1xfb I:3-344 [121930]
    automatically matched to 1XFB A:3-344
  10. Domain d1xfbj1: 1xfb J:3-344 [121931]
    automatically matched to 1XFB A:3-344
  11. Domain d1xfbk1: 1xfb K:3-344 [121932]
    automatically matched to 1XFB A:3-344
  12. Domain d1xfbl1: 1xfb L:3-344 [121933]
    automatically matched to 1XFB A:3-344
Human (Homo sapiens), liver isozyme [TaxId:9606] [51578] (3 PDB entries)
1. Domains for 1qo5:
  1. Domain d1qo5a_: 1qo5 A: [29102]
  2. Domain d1qo5b_: 1qo5 B: [29103]
  3. Domain d1qo5c_: 1qo5 C: [29104]
  4. Domain d1qo5d_: 1qo5 D: [29105]
  5. Domain d1qo5e_: 1qo5 E: [29106]
  6. Domain d1qo5f_: 1qo5 F: [29107]
  7. Domain d1qo5g_: 1qo5 G: [29108]
  8. Domain d1qo5h_: 1qo5 H: [29109]
  9. Domain d1qo5i_: 1qo5 I: [29110]
  10. Domain d1qo5j_: 1qo5 J: [29111]
  11. Domain d1qo5k_: 1qo5 K: [29112]
  12. Domain d1qo5l_: 1qo5 L: [29113]
  13. Domain d1qo5m_: 1qo5 M: [29114]
  14. Domain d1qo5n_: 1qo5 N: [29115]
  15. Domain d1qo5o_: 1qo5 O: [29116]
  16. Domain d1qo5p_: 1qo5 P: [29117]
  17. Domain d1qo5q_: 1qo5 Q: [29118]
  18. Domain d1qo5r_: 1qo5 R: [29119]
    complexed with so4
2. Domains for 1xdl:
  1. Domain d1xdla1: 1xdl A:6-343 [121872]
    complexed with so4; mutant
  2. Domain d1xdlb1: 1xdl B:6-343 [121873]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  3. Domain d1xdlc1: 1xdl C:6-343 [121874]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  4. Domain d1xdld1: 1xdl D:6-343 [121875]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  5. Domain d1xdlw1: 1xdl W:6-343 [121876]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  6. Domain d1xdlx1: 1xdl X:6-343 [121877]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  7. Domain d1xdly1: 1xdl Y:6-343 [121878]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  8. Domain d1xdlz1: 1xdl Z:6-342 [121879]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
3. Domains for 1xdm:
  1. Domain d1xdma1: 1xdm A:6-342 [121880]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  2. Domain d1xdmb1: 1xdm B:6-343 [121881]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  3. Domain d1xdmc1: 1xdm C:6-343 [121882]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  4. Domain d1xdmd1: 1xdm D:6-342 [121883]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  5. Domain d1xdmw1: 1xdm W:6-343 [121884]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  6. Domain d1xdmx1: 1xdm X:6-343 [121885]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  7. Domain d1xdmy1: 1xdm Y:6-343 [121886]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
  8. Domain d1xdmz1: 1xdm Z:6-342 [121887]
    automatically matched to 1XDL A:6-343
    complexed with so4; mutant
Human (Homo sapiens), muscle isozyme [TaxId:9606] [51577] (3 PDB entries)
1. Domain for 1ald:
  - Domain d1alda_: 1ald A: [29100]
2. Domain for 2ald:
  - Domain d2alda_: 2ald A: [29099]
3. Domain for 4ald:
  - Domain d4alda_: 4ald A: [29101]
    complexed with 2fp
Plasmodium falciparum [TaxId:5833] [51581] (1 PDB entry)
- Domains for 1a5c:
  1. Domain d1a5ca_: 1a5c A: [29148]
  2. Domain d1a5cb_: 1a5c B: [29149]
Plasmodium yoelii yoelii [TaxId:73239] [141833] (1 PDB entry)
- Domains for 2a4a:
  1. Domain d2a4aa1: 2a4a A:3-258 [126150]
  2. Domain d2a4ab1: 2a4a B:3-258 [126151]
    automatically matched to 2A4A A:3-258
Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId:9986] [63920] (1 PDB entry)
- Domains for 1fdj:
  1. Domain d1fdja_: 1fdj A: [59772]
  2. Domain d1fdjb_: 1fdj B: [59773]
  3. Domain d1fdjc_: 1fdj C: [59774]
  4. Domain d1fdjd_: 1fdj D: [59775]
    complexed with 13p, 2fp, g3p, so4
Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId:9986] [51580] (13 PDB entries)
1. Domains for 1ado:
  1. Domain d1adoa_: 1ado A: [29124]
  2. Domain d1adob_: 1ado B: [29125]
  3. Domain d1adoc_: 1ado C: [29126]
  4. Domain d1adod_: 1ado D: [29127]
    complexed with 13p, so4
2. Domains for 1ewd:
  1. Domain d1ewda_: 1ewd A: [29132]
  2. Domain d1ewdb_: 1ewd B: [29133]
  3. Domain d1ewdc_: 1ewd C: [29134]
  4. Domain d1ewdd_: 1ewd D: [29135]
    mutant
3. Domains for 1ewe:
  1. Domain d1ewea_: 1ewe A: [29136]
  2. Domain d1eweb_: 1ewe B: [29137]
  3. Domain d1ewec_: 1ewe C: [29138]
  4. Domain d1ewed_: 1ewe D: [29139]
    complexed with so4; mutant
4. Domains for 1ewg:
  1. Domain d1ewga_: 1ewg A: [29128]
  2. Domain d1ewgb_: 1ewg B: [29129]
  3. Domain d1ewgc_: 1ewg C: [29130]
  4. Domain d1ewgd_: 1ewg D: [29131]
    mutant
5. Domains for 1ex5:
  1. Domain d1ex5a_: 1ex5 A: [29140]
  2. Domain d1ex5b_: 1ex5 B: [29141]
  3. Domain d1ex5c_: 1ex5 C: [29142]
  4. Domain d1ex5d_: 1ex5 D: [29143]
    mutant
6. Domains for 1j4e:
  1. Domain d1j4ea_: 1j4e A: [66375]
  2. Domain d1j4eb_: 1j4e B: [66376]
  3. Domain d1j4ec_: 1j4e C: [66377]
  4. Domain d1j4ed_: 1j4e D: [66378]
    complexed with 13p; mutant
7. Domains for 1zah:
  1. Domain d1zaha1: 1zah A:1-363 [124824]
  2. Domain d1zahb1: 1zah B:1-363 [124825]
    automatically matched to 1ZAH A:1-363
  3. Domain d1zahc1: 1zah C:1-363 [124826]
    automatically matched to 1ZAH A:1-363
  4. Domain d1zahd1: 1zah D:1-363 [124827]
    automatically matched to 1ZAH A:1-363
8. Domains for 1zai:
  1. Domain d1zaia1: 1zai A:1-363 [124828]
    automatically matched to 1ZAH A:1-363
    complexed with 2fp
  2. Domain d1zaib1: 1zai B:1-363 [124829]
    automatically matched to 1ZAH A:1-363
    complexed with 2fp
  3. Domain d1zaic1: 1zai C:1-363 [124830]
    automatically matched to 1ZAH A:1-363
    complexed with 2fp
  4. Domain d1zaid1: 1zai D:1-363 [124831]
    automatically matched to 1ZAH A:1-363
    complexed with 2fp
9. Domains for 1zaj:
  1. Domain d1zaja1: 1zaj A:1-363 [124832]
    automatically matched to 1ZAH A:1-363
    complexed with m2p
  2. Domain d1zajb1: 1zaj B:1-363 [124833]
    automatically matched to 1ZAH A:1-363
    complexed with m2p
  3. Domain d1zajc1: 1zaj C:1-363 [124834]
    automatically matched to 1ZAH A:1-363
    complexed with m2p
  4. Domain d1zajd1: 1zaj D:1-363 [124835]
    automatically matched to 1ZAH A:1-363
    complexed with m2p
10. Domains for 1zal:
  1. Domain d1zala1: 1zal A:1-363 [124836]
    automatically matched to 1ZAH A:1-363
    complexed with po4
  2. Domain d1zalb1: 1zal B:1-363 [124837]
    automatically matched to 1ZAH A:1-363
    complexed with po4
  3. Domain d1zalc1: 1zal C:1-363 [124838]
    automatically matched to 1ZAH A:1-363
    complexed with po4
  4. Domain d1zald1: 1zal D:1-363 [124839]
    automatically matched to 1ZAH A:1-363
    complexed with po4
11. Domains for 2ot0:
  1. Domain d2ot0a1: 2ot0 A:1-363 [139303]
    automatically matched to 1ZAH A:1-363
  2. Domain d2ot0b1: 2ot0 B:1-363 [139304]
    automatically matched to 1ZAH A:1-363
  3. Domain d2ot0c1: 2ot0 C:1-363 [139305]
    automatically matched to 1ZAH A:1-363
  4. Domain d2ot0d1: 2ot0 D:1-363 [139306]
    automatically matched to 1ZAH A:1-363
12. Domains for 2ot1:
  1. Domain d2ot1a1: 2ot1 A:1-363 [139307]
    automatically matched to 1ZAH A:1-363
    complexed with n3p
  2. Domain d2ot1b1: 2ot1 B:1-363 [139308]
    automatically matched to 1ZAH A:1-363
    complexed with n3p
  3. Domain d2ot1c1: 2ot1 C:1-363 [139309]
    automatically matched to 1ZAH A:1-363
    complexed with n3p
  4. Domain d2ot1d1: 2ot1 D:1-363 [139310]
    automatically matched to 1ZAH A:1-363
    complexed with n3p
13. Domains for 6ald:
  1. Domain d6alda_: 6ald A: [29144]
  2. Domain d6aldb_: 6ald B: [29145]
  3. Domain d6aldc_: 6ald C: [29146]
  4. Domain d6aldd_: 6ald D: [29147]
Trypanosome (Leishmania mexicana) [TaxId:5665] [51582] (1 PDB entry)
- Domains for 1epx:
  1. Domain d1epxa_: 1epx A: [29150]
  2. Domain d1epxb_: 1epx B: [29151]
  3. Domain d1epxc_: 1epx C: [29152]
  4. Domain d1epxd_: 1epx D: [29153]
Trypanosome (Trypanosoma brucei) [TaxId:5691] [51583] (1 PDB entry)
- Domain for 1f2j:
  - Domain d1f2ja_: 1f2j A: [29154]

More info for Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase

Timeline for Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase:

Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase first appeared (with stable ids) in SCOP 1.55
Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase appears in SCOP 1.71
Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase appears in SCOP 1.75
Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase appears in the current release, SCOPe 2.08