Lineage for Protein: Fructose-1,6-bisphosphate aldolase

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2413227Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2420459Superfamily c.1.10: Aldolase [51569] (9 families) (S)
    Common fold covers whole protein structure
  5. 2420460Family c.1.10.1: Class I aldolase [51570] (13 proteins)
    the catalytic lysine forms schiff-base intermediate with substrate
    possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels
  6. 2420694Protein Fructose-1,6-bisphosphate aldolase [51576] (11 species)

Species:

  1. 2420695Fruit fly (Drosophila melanogaster) [TaxId:7227] [51579] (1 PDB entry)
  2. 2420700Human (Homo sapiens) [TaxId:9606] [254964] (2 PDB entries)
    1. Domains for 1xdl:
      1. 2420709Domain d1xdlb_: 1xdl B: [121873]
        automated match to d1fdja_
        complexed with so4
      2. 2420710Domain d1xdlc_: 1xdl C: [121874]
        automated match to d1fdja_
        complexed with so4
      3. 2420711Domain d1xdld_: 1xdl D: [121875]
        automated match to d1fdja_
        complexed with so4
      4. 2420712Domain d1xdlw_: 1xdl W: [121876]
        automated match to d1fdja_
        complexed with so4
      5. 2420713Domain d1xdlx_: 1xdl X: [121877]
        automated match to d1fdja_
        complexed with so4
      6. 2420714Domain d1xdly_: 1xdl Y: [121878]
        automated match to d1fdja_
        complexed with so4
      7. 2420715Domain d1xdlz_: 1xdl Z: [121879]
        automated match to d1fdja_
        complexed with so4
    2. Domains for 1xdm:
      1. 2420701Domain d1xdma_: 1xdm A: [121880]
        automated match to d1fdja_
        complexed with so4
      2. 2420702Domain d1xdmb_: 1xdm B: [121881]
        automated match to d1fdja_
        complexed with so4
      3. 2420703Domain d1xdmc_: 1xdm C: [121882]
        automated match to d1fdja_
        complexed with so4
      4. 2420704Domain d1xdmd_: 1xdm D: [121883]
        automated match to d1fdja_
        complexed with so4
      5. 2420705Domain d1xdmw_: 1xdm W: [121884]
        automated match to d1fdja_
        complexed with so4
      6. 2420706Domain d1xdmx_: 1xdm X: [121885]
        automated match to d1fdja_
        complexed with so4
      7. 2420707Domain d1xdmy_: 1xdm Y: [121886]
        automated match to d1fdja_
        complexed with so4
      8. 2420708Domain d1xdmz_: 1xdm Z: [121887]
        automated match to d1fdja_
        complexed with so4
  3. 2420716Human (Homo sapiens), brain isozyme [TaxId:9606] [141834] (1 PDB entry)
    Uniprot P09972 2-343
  4. 2420718Human (Homo sapiens), liver isozyme [TaxId:9606] [51578] (2 PDB entries)
    1. Domains for 1qo5:
      1. 2420719Domain d1qo5a_: 1qo5 A: [29102]
        complexed with so4
      2. 2420720Domain d1qo5b_: 1qo5 B: [29103]
        complexed with so4
      3. 2420721Domain d1qo5c_: 1qo5 C: [29104]
        complexed with so4
      4. 2420722Domain d1qo5d_: 1qo5 D: [29105]
        complexed with so4
      5. 2420723Domain d1qo5e_: 1qo5 E: [29106]
        complexed with so4
      6. 2420724Domain d1qo5f_: 1qo5 F: [29107]
        complexed with so4
      7. 2420725Domain d1qo5g_: 1qo5 G: [29108]
        complexed with so4
      8. 2420726Domain d1qo5h_: 1qo5 H: [29109]
        complexed with so4
      9. 2420727Domain d1qo5i_: 1qo5 I: [29110]
        complexed with so4
      10. 2420728Domain d1qo5j_: 1qo5 J: [29111]
        complexed with so4
      11. 2420729Domain d1qo5k_: 1qo5 K: [29112]
        complexed with so4
      12. 2420730Domain d1qo5l_: 1qo5 L: [29113]
        complexed with so4
      13. 2420731Domain d1qo5m_: 1qo5 M: [29114]
        complexed with so4
      14. 2420732Domain d1qo5n_: 1qo5 N: [29115]
        complexed with so4
      15. 2420733Domain d1qo5o_: 1qo5 O: [29116]
        complexed with so4
      16. 2420734Domain d1qo5p_: 1qo5 P: [29117]
        complexed with so4
      17. 2420735Domain d1qo5q_: 1qo5 Q: [29118]
        complexed with so4
      18. 2420736Domain d1qo5r_: 1qo5 R: [29119]
        complexed with so4
    2. Domain for 1xdl:
  5. 2420738Human (Homo sapiens), muscle isozyme [TaxId:9606] [51577] (4 PDB entries)
    1. Domain for 1ald:
    2. Domain for 2ald:
    3. Domain for 4ald:
    4. Domains for 5ky6:
      1. 2420740Domain d5ky6a_: 5ky6 A: [336081]
        automated match to d2alda_
      2. 2420741Domain d5ky6b_: 5ky6 B: [336096]
        automated match to d2alda_
      3. 2420742Domain d5ky6c_: 5ky6 C: [336017]
        automated match to d2alda_
      4. 2420743Domain d5ky6d_: 5ky6 D: [336056]
        automated match to d2alda_
  6. 2420746Malaria parasite (Plasmodium falciparum) [TaxId:5833] [51581] (1 PDB entry)
  7. 2420749Plasmodium yoelii yoelii [TaxId:73239] [141833] (1 PDB entry)
    Uniprot Q7RMC9 3-258
  8. 2420752Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId:9986] [63920] (1 PDB entry)
  9. 2420757Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId:9986] [51580] (31 PDB entries)
    1. Domains for 1ado:
      1. 2420778Domain d1adoa_: 1ado A: [29124]
        complexed with 13p, so4
      2. 2420779Domain d1adob_: 1ado B: [29125]
        complexed with 13p, so4
      3. 2420780Domain d1adoc_: 1ado C: [29126]
        complexed with 13p, so4
      4. 2420781Domain d1adod_: 1ado D: [29127]
        complexed with 13p, so4
    2. Domains for 1ewd:
      1. 2420867Domain d1ewda_: 1ewd A: [29132]
      2. 2420868Domain d1ewdb_: 1ewd B: [29133]
      3. 2420869Domain d1ewdc_: 1ewd C: [29134]
      4. 2420870Domain d1ewdd_: 1ewd D: [29135]
    3. Domains for 1ewe:
      1. 2420875Domain d1ewea_: 1ewe A: [29136]
        complexed with so4
      2. 2420876Domain d1eweb_: 1ewe B: [29137]
        complexed with so4
      3. 2420877Domain d1ewec_: 1ewe C: [29138]
        complexed with so4
      4. 2420878Domain d1ewed_: 1ewe D: [29139]
        complexed with so4
    4. Domains for 1ex5:
      1. 2420863Domain d1ex5a_: 1ex5 A: [29140]
      2. 2420864Domain d1ex5b_: 1ex5 B: [29141]
      3. 2420865Domain d1ex5c_: 1ex5 C: [29142]
      4. 2420866Domain d1ex5d_: 1ex5 D: [29143]
    5. Domains for 1j4e:
      1. 2420843Domain d1j4ea_: 1j4e A: [66375]
        complexed with 13p
      2. 2420844Domain d1j4eb_: 1j4e B: [66376]
        complexed with 13p
      3. 2420845Domain d1j4ec_: 1j4e C: [66377]
        complexed with 13p
      4. 2420846Domain d1j4ed_: 1j4e D: [66378]
        complexed with 13p
    6. Domains for 1zah:
      1. 2420811Domain d1zaha1: 1zah A:1-363 [124824]
      2. 2420812Domain d1zahb_: 1zah B: [124825]
        automated match to d1adoa_
      3. 2420813Domain d1zahc_: 1zah C: [124826]
        automated match to d1adoa_
      4. 2420814Domain d1zahd_: 1zah D: [124827]
        automated match to d1adoa_
    7. Domains for 1zai:
      1. 2420807Domain d1zaia_: 1zai A: [124828]
        automated match to d1adoa_
        complexed with 2fp
      2. 2420808Domain d1zaib_: 1zai B: [124829]
        automated match to d1adoa_
        complexed with 2fp
      3. 2420809Domain d1zaic_: 1zai C: [124830]
        automated match to d1adoa_
        complexed with 2fp
      4. 2420810Domain d1zaid_: 1zai D: [124831]
        automated match to d1adoa_
        complexed with 2fp
    8. Domains for 1zaj:
      1. 2420823Domain d1zaja_: 1zaj A: [124832]
        automated match to d1adoa_
        complexed with m2p
      2. 2420824Domain d1zajb_: 1zaj B: [124833]
        automated match to d1adoa_
        complexed with m2p
      3. 2420825Domain d1zajc_: 1zaj C: [124834]
        automated match to d1adoa_
        complexed with m2p
      4. 2420826Domain d1zajd_: 1zaj D: [124835]
        automated match to d1adoa_
        complexed with m2p
    9. Domains for 1zal:
      1. 2420819Domain d1zala_: 1zal A: [124836]
        automated match to d1adoa_
        complexed with po4
      2. 2420820Domain d1zalb_: 1zal B: [124837]
        automated match to d1adoa_
        complexed with po4
      3. 2420821Domain d1zalc_: 1zal C: [124838]
        automated match to d1adoa_
        complexed with po4
      4. 2420822Domain d1zald_: 1zal D: [124839]
        automated match to d1adoa_
        complexed with po4
    10. Domains for 2ot0:
      1. 2420798Domain d2ot0a_: 2ot0 A: [139303]
        automated match to d1adoa_
      2. 2420799Domain d2ot0b_: 2ot0 B: [139304]
        automated match to d1adoa_
      3. 2420800Domain d2ot0c_: 2ot0 C: [139305]
        automated match to d1adoa_
      4. 2420801Domain d2ot0d_: 2ot0 D: [139306]
        automated match to d1adoa_
    11. Domains for 2ot1:
      1. 2420790Domain d2ot1a_: 2ot1 A: [139307]
        automated match to d1adoa_
        complexed with n3p
      2. 2420791Domain d2ot1b_: 2ot1 B: [139308]
        automated match to d1adoa_
        complexed with n3p
      3. 2420792Domain d2ot1c_: 2ot1 C: [139309]
        automated match to d1adoa_
        complexed with n3p
      4. 2420793Domain d2ot1d_: 2ot1 D: [139310]
        automated match to d1adoa_
        complexed with n3p
    12. Domains for 2qut:
      1. 2420766Domain d2quta_: 2qut A: [151376]
        automated match to d1adoa_
        complexed with 13p
      2. 2420767Domain d2qutb_: 2qut B: [151377]
        automated match to d1adoa_
        complexed with 13p
      3. 2420768Domain d2qutc_: 2qut C: [151378]
        automated match to d1adoa_
        complexed with 13p
      4. 2420769Domain d2qutd_: 2qut D: [151379]
        automated match to d1adoa_
        complexed with 13p
    13. Domains for 2quu:
      1. 2420831Domain d2quua_: 2quu A: [167814]
        automated match to d1adoa_
        complexed with 13p; mutant
      2. 2420832Domain d2quub_: 2quu B: [167815]
        automated match to d1adoa_
        complexed with 13p; mutant
      3. 2420833Domain d2quuc_: 2quu C: [167816]
        automated match to d1adoa_
        complexed with 13p; mutant
      4. 2420834Domain d2quud_: 2quu D: [167817]
        automated match to d1adoa_
        complexed with 13p; mutant
    14. Domains for 2quv:
      1. 2420855Domain d2quva_: 2quv A: [151380]
        automated match to d1adoa_
        complexed with po4
      2. 2420856Domain d2quvb_: 2quv B: [151381]
        automated match to d1adoa_
        complexed with po4
      3. 2420857Domain d2quvc_: 2quv C: [151382]
        automated match to d1adoa_
        complexed with po4
      4. 2420858Domain d2quvd_: 2quv D: [151383]
        automated match to d1adoa_
        complexed with po4
    15. Domains for 3b8d:
      1. 2420835Domain d3b8da_: 3b8d A: [154951]
        automated match to d1adoa_
        complexed with so4
      2. 2420836Domain d3b8db_: 3b8d B: [154952]
        automated match to d1adoa_
        complexed with so4
      3. 2420837Domain d3b8dc_: 3b8d C: [154953]
        automated match to d1adoa_
        complexed with so4
      4. 2420838Domain d3b8dd_: 3b8d D: [154954]
        automated match to d1adoa_
        complexed with so4
    16. Domain for 3bv4:
    17. Domains for 3dfn:
      1. 2420762Domain d3dfna_: 3dfn A: [173892]
        automated match to d1adoa_
        mutant
      2. 2420763Domain d3dfnb_: 3dfn B: [173893]
        automated match to d1adoa_
        mutant
      3. 2420764Domain d3dfnc_: 3dfn C: [173894]
        automated match to d1adoa_
        mutant
      4. 2420765Domain d3dfnd_: 3dfn D: [173895]
        automated match to d1adoa_
        mutant
    18. Domains for 3dfo:
      1. 2420774Domain d3dfoa_: 3dfo A: [173896]
        automated match to d1adoa_
        complexed with 13p; mutant
      2. 2420775Domain d3dfob_: 3dfo B: [173897]
        automated match to d1adoa_
        complexed with 13p; mutant
      3. 2420776Domain d3dfoc_: 3dfo C: [173898]
        automated match to d1adoa_
        complexed with 13p; mutant
      4. 2420777Domain d3dfod_: 3dfo D: [173899]
        automated match to d1adoa_
        complexed with 13p; mutant
    19. Domains for 3dfp:
      1. 2420786Domain d3dfpa_: 3dfp A: [173900]
        automated match to d1adoa_
        complexed with po4; mutant
      2. 2420787Domain d3dfpb_: 3dfp B: [173901]
        automated match to d1adoa_
        complexed with po4; mutant
      3. 2420788Domain d3dfpc_: 3dfp C: [173902]
        automated match to d1adoa_
        complexed with po4; mutant
      4. 2420789Domain d3dfpd_: 3dfp D: [173903]
        automated match to d1adoa_
        complexed with po4; mutant
    20. Domains for 3dfq:
      1. 2420758Domain d3dfqa_: 3dfq A: [173904]
        automated match to d1adoa_
        mutant
      2. 2420759Domain d3dfqb_: 3dfq B: [173905]
        automated match to d1adoa_
        mutant
      3. 2420760Domain d3dfqc_: 3dfq C: [173906]
        automated match to d1adoa_
        mutant
      4. 2420761Domain d3dfqd_: 3dfq D: [173907]
        automated match to d1adoa_
        mutant
    21. Domains for 3dfs:
      1. 2420782Domain d3dfsa_: 3dfs A: [173908]
        automated match to d1adoa_
        complexed with 13p; mutant
      2. 2420783Domain d3dfsb_: 3dfs B: [173909]
        automated match to d1adoa_
        complexed with 13p; mutant
      3. 2420784Domain d3dfsc_: 3dfs C: [173910]
        automated match to d1adoa_
        complexed with 13p; mutant
      4. 2420785Domain d3dfsd_: 3dfs D: [173911]
        automated match to d1adoa_
        complexed with 13p; mutant
    22. Domains for 3dft:
      1. 2420770Domain d3dfta_: 3dft A: [173912]
        automated match to d1adoa_
        complexed with po4; mutant
      2. 2420771Domain d3dftb_: 3dft B: [173913]
        automated match to d1adoa_
        complexed with po4; mutant
      3. 2420772Domain d3dftc_: 3dft C: [173914]
        automated match to d1adoa_
        complexed with po4; mutant
      4. 2420773Domain d3dftd_: 3dft D: [173915]
        automated match to d1adoa_
        complexed with po4; mutant
    23. Domains for 3lge:
      1. 2420851Domain d3lgea_: 3lge A: [180274]
        automated match to d1adoa_
      2. 2420852Domain d3lgeb_: 3lge B: [180275]
        automated match to d1adoa_
      3. 2420853Domain d3lgec_: 3lge C: [180276]
        automated match to d1adoa_
      4. 2420854Domain d3lged_: 3lge D: [180277]
        automated match to d1adoa_
    24. Domains for 3tu9:
      1. 2420794Domain d3tu9a_: 3tu9 A: [185952]
        automated match to d1adoa_
        complexed with 5mm
      2. 2420795Domain d3tu9b_: 3tu9 B: [185953]
        automated match to d1adoa_
        complexed with 5mm
      3. 2420796Domain d3tu9c_: 3tu9 C: [185954]
        automated match to d1adoa_
        complexed with 5mm
      4. 2420797Domain d3tu9d_: 3tu9 D: [185955]
        automated match to d1adoa_
        complexed with 5mm
    25. Domains for 5f4x:
      1. 2420815Domain d5f4xa_: 5f4x A: [327631]
        automated match to d1ewea_
        complexed with gol; mutant
      2. 2420816Domain d5f4xb_: 5f4x B: [327552]
        automated match to d1ewea_
        complexed with gol; mutant
      3. 2420817Domain d5f4xc_: 5f4x C: [327553]
        automated match to d1ewea_
        complexed with gol; mutant
      4. 2420818Domain d5f4xd_: 5f4x D: [327615]
        automated match to d1ewea_
        complexed with gol; mutant
    26. Domains for 5tle:
      1. 2420802Domain d5tlea_: 5tle A: [340613]
        automated match to d1zaha1
        complexed with gol, rd1
      2. 2420803Domain d5tleb_: 5tle B: [340651]
        automated match to d1zaha1
        complexed with gol, rd1
      3. 2420804Domain d5tlec_: 5tle C: [340616]
        automated match to d1zaha1
        complexed with gol, rd1
      4. 2420805Domain d5tled_: 5tle D: [340614]
        automated match to d1zaha1
        complexed with gol, rd1
    27. Domains for 5tlh:
      1. 2420847Domain d5tlha_: 5tlh A: [340659]
        automated match to d1zaha1
        complexed with gol, mdn, rd2
      2. 2420848Domain d5tlhb_: 5tlh B: [340800]
        automated match to d1zaha1
        complexed with gol, mdn, rd2
      3. 2420849Domain d5tlhc_: 5tlh C: [340728]
        automated match to d1zaha1
        complexed with gol, mdn, rd2
      4. 2420850Domain d5tlhd_: 5tlh D: [340776]
        automated match to d1zaha1
        complexed with gol, mdn, rd2
    28. Domains for 5tlw:
      1. 2420859Domain d5tlwa_: 5tlw A: [340637]
        automated match to d1zaha1
        complexed with gol, rd3
      2. 2420860Domain d5tlwb_: 5tlw B: [340734]
        automated match to d1zaha1
        complexed with gol, rd3
      3. 2420861Domain d5tlwc_: 5tlw C: [340793]
        automated match to d1zaha1
        complexed with gol, rd3
      4. 2420862Domain d5tlwd_: 5tlw D: [340646]
        automated match to d1zaha1
        complexed with gol, rd3
    29. Domains for 5tlz:
      1. 2420827Domain d5tlza_: 5tlz A: [340609]
        automated match to d1zaha1
        complexed with gol, n26
      2. 2420828Domain d5tlzb_: 5tlz B: [340610]
        automated match to d1zaha1
        complexed with gol, n26
      3. 2420829Domain d5tlzc_: 5tlz C: [340608]
        automated match to d1zaha1
        complexed with gol, n26
      4. 2420830Domain d5tlzd_: 5tlz D: [340677]
        automated match to d1zaha1
        complexed with gol, n26
    30. Domains for 5vy5:
      1. 2420871Domain d5vy5a_: 5vy5 A: [335478]
        automated match to d1zaha1
      2. 2420872Domain d5vy5b_: 5vy5 B: [335496]
        automated match to d1zaha1
      3. 2420873Domain d5vy5c_: 5vy5 C: [335538]
        automated match to d1zaha1
      4. 2420874Domain d5vy5d_: 5vy5 D: [335473]
        automated match to d1zaha1
    31. Domains for 6ald:
      1. 2420839Domain d6alda_: 6ald A: [29144]
        complexed with 2fp
      2. 2420840Domain d6aldb_: 6ald B: [29145]
        complexed with 2fp
      3. 2420841Domain d6aldc_: 6ald C: [29146]
        complexed with 2fp
      4. 2420842Domain d6aldd_: 6ald D: [29147]
        complexed with 2fp
  10. Trypanosome (Leishmania mexicana) [TaxId:5665] [51582] (1 PDB entry)
  11. 2420884Trypanosome (Trypanosoma brucei) [TaxId:5691] [51583] (1 PDB entry)

More info for Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase

Timeline for Protein Fructose-1,6-bisphosphate aldolase from c.1.10.1: Class I aldolase: