Lineage for Family c.1.10.1: Class I aldolase

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 814174Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 817252Superfamily c.1.10: Aldolase [51569] (8 families) (S)
    Common fold covers whole protein structure
  5. 817253Family c.1.10.1: Class I aldolase [51570] (12 proteins)
    the catalytic lysine forms schiff-base intermediate with substrate
    possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels

Proteins:

  1. 8172542-keto-3-deoxy gluconate aldolase Eda [110360] (1 species)
  2. 817272Archaeal fructose 1,6-bisphosphate aldolase [102088] (1 species)
  3. 817324Decameric fructose-6-phosphate aldolase/transaldolase [75085] (3 species)
    forms helix-swapped pentamers
    1. 817325Species Escherichia coli [TaxId:562] [75086] (1 PDB entry)
    2. 817336Species Thermotoga maritima [TaxId:2336] [117379] (1 PDB entry)
      Uniprot Q9WYD1
    3. 817357Species Thermus thermophilus [TaxId:274] [141836] (1 PDB entry)
      Uniprot Q5SJE8 1-211
      clear orthologue of the E.coli protein; annotated as transaldolase in UniProt
  4. 817368Deoxyribose-phosphate aldolase DeoC [69394] (6 species)
    1. 817369Species Aquifex aeolicus [TaxId:63363] [82271] (1 PDB entry)
    2. 817372Species Archaeon Aeropyrum pernix [TaxId:56636] [89493] (1 PDB entry)
    3. 817375Species Archaeon Pyrobaculum aerophilum [TaxId:13773] [141830] (1 PDB entry)
      Uniprot Q8ZXK7 1-226
    4. 817378Species Escherichia coli [TaxId:562] [69395] (4 PDB entries)
      Uniprot P00882
    5. 817387Species Thermotoga maritima [TaxId:2336] [82270] (1 PDB entry)
      TM1559
    6. 817390Species Thermus thermophilus [TaxId:274] [89492] (2 PDB entries)
  5. 817399Dihydrodipicolinate synthase [51574] (4 species)
    1. 817400Species Bacillus anthracis [TaxId:1392] [141832] (2 PDB entries)
      Uniprot Q81WN7 1-292
    2. 817409Species Escherichia coli [TaxId:562] [51575] (9 PDB entries)
    3. 817428Species Mycobacterium tuberculosis [TaxId:1773] [141831] (1 PDB entry)
      Uniprot P63945 5-300
    4. 817437Species Thermotoga maritima [TaxId:2336] [102090] (1 PDB entry)
  6. 817440Fructose-1,6-bisphosphate aldolase [51576] (10 species)
    1. 817441Species Drosophila melanogaster [TaxId:7227] [51579] (1 PDB entry)
    2. 817446Species Human (Homo sapiens), brain isozyme [TaxId:9606] [141834] (1 PDB entry)
      Uniprot P09972 2-343
    3. 817459Species Human (Homo sapiens), liver isozyme [TaxId:9606] [51578] (3 PDB entries)
    4. 817494Species Human (Homo sapiens), muscle isozyme [TaxId:9606] [51577] (3 PDB entries)
    5. 817498Species Plasmodium falciparum [TaxId:5833] [51581] (1 PDB entry)
    6. 817501Species Plasmodium yoelii yoelii [TaxId:73239] [141833] (1 PDB entry)
      Uniprot Q7RMC9 3-258
    7. 817504Species Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId:9986] [63920] (1 PDB entry)
    8. 817509Species Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId:9986] [51580] (15 PDB entries)
    9. 817570Species Trypanosome (Leishmania mexicana) [TaxId:5665] [51582] (4 PDB entries)
    10. 817587Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [51583] (1 PDB entry)
  7. 817589Hypothetical protein HI0047 [102092] (1 species)
    putative KHG/KDPG aldolase
  8. 817597KDPG aldolase [51584] (3 species)
    1. 817598Species Escherichia coli [TaxId:562] [51585] (7 PDB entries)
    2. 817618Species Pseudomonas putida [TaxId:303] [102091] (1 PDB entry)
    3. 817620Species Thermotoga maritima [TaxId:2336] [110357] (2 PDB entries)
      Uniprot Q9WXS1
  9. 817630N-acetylneuraminate lyase [51571] (2 species)
    1. 817631Species Escherichia coli [TaxId:562] [51572] (4 PDB entries)
    2. 817648Species Haemophilus influenzae [TaxId:727] [51573] (6 PDB entries)
  10. 817667Putative aldolase YihT [110358] (1 species)
  11. 817670Transaldolase [51588] (3 species)
    probably related to class I aldolases by a circular permutation
    1. 817671Species Escherichia coli [TaxId:562] [51589] (7 PDB entries)
    2. 817686Species Human (Homo sapiens) [TaxId:9606] [51590] (1 PDB entry)
    3. 817689Species Mouse (Mus musculus) [TaxId:10090] [141835] (2 PDB entries)
      Uniprot Q93092 13-331
  12. 817694Type I 3-dehydroquinate dehydratase [51586] (2 species)
    1. 817695Species Salmonella typhi [TaxId:90370] [51587] (3 PDB entries)
    2. 817703Species Staphylococcus aureus [TaxId:1280] [117378] (2 PDB entries)
      Uniprot Q6GII7

More info for Family c.1.10.1: Class I aldolase

Timeline for Family c.1.10.1: Class I aldolase: