Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies) contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678 the first seven superfamilies have similar phosphate-binding sites |
Superfamily c.1.10: Aldolase [51569] (8 families) Common fold covers whole protein structure |
Family c.1.10.1: Class I aldolase [51570] (12 proteins) the catalytic lysine forms schiff-base intermediate with substrate possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels |
2-keto-3-deoxy gluconate aldolase Eda [110360] (1 species) |
Species Sulfolobus solfataricus [TaxId:2287] [110361] (4 PDB entries) Uniprot Q97U28 |
Archaeal fructose 1,6-bisphosphate aldolase [102088] (1 species) |
Species Archaeon Thermoproteus tenax [TaxId:2271] [102089] (5 PDB entries) |
Decameric fructose-6-phosphate aldolase/transaldolase [75085] (3 species) forms helix-swapped pentamers |
Species Escherichia coli [TaxId:562] [75086] (1 PDB entry) |
Species Thermotoga maritima [TaxId:2336] [117379] (1 PDB entry) Uniprot Q9WYD1 |
Species Thermus thermophilus [TaxId:274] [141836] (1 PDB entry) Uniprot Q5SJE8 1-211 clear orthologue of the E.coli protein; annotated as transaldolase in UniProt |
Deoxyribose-phosphate aldolase DeoC [69394] (6 species) |
Species Aquifex aeolicus [TaxId:63363] [82271] (1 PDB entry) |
Species Archaeon Aeropyrum pernix [TaxId:56636] [89493] (1 PDB entry) |
Species Archaeon Pyrobaculum aerophilum [TaxId:13773] [141830] (1 PDB entry) Uniprot Q8ZXK7 1-226 |
Species Escherichia coli [TaxId:562] [69395] (4 PDB entries) Uniprot P00882 |
Species Thermotoga maritima [TaxId:2336] [82270] (1 PDB entry) TM1559 |
Species Thermus thermophilus [TaxId:274] [89492] (2 PDB entries) |
Dihydrodipicolinate synthase [51574] (4 species) |
Species Bacillus anthracis [TaxId:1392] [141832] (2 PDB entries) Uniprot Q81WN7 1-292 |
Species Escherichia coli [TaxId:562] [51575] (9 PDB entries) |
Species Mycobacterium tuberculosis [TaxId:1773] [141831] (1 PDB entry) Uniprot P63945 5-300 |
Species Thermotoga maritima [TaxId:2336] [102090] (1 PDB entry) |
Fructose-1,6-bisphosphate aldolase [51576] (10 species) |
Species Drosophila melanogaster [TaxId:7227] [51579] (1 PDB entry) |
Species Human (Homo sapiens), brain isozyme [TaxId:9606] [141834] (1 PDB entry) Uniprot P09972 2-343 |
Species Human (Homo sapiens), liver isozyme [TaxId:9606] [51578] (3 PDB entries) |
Species Human (Homo sapiens), muscle isozyme [TaxId:9606] [51577] (3 PDB entries) |
Species Plasmodium falciparum [TaxId:5833] [51581] (1 PDB entry) |
Species Plasmodium yoelii yoelii [TaxId:73239] [141833] (1 PDB entry) Uniprot Q7RMC9 3-258 |
Species Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId:9986] [63920] (1 PDB entry) |
Species Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId:9986] [51580] (15 PDB entries) |
Species Trypanosome (Leishmania mexicana) [TaxId:5665] [51582] (4 PDB entries) |
Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [51583] (1 PDB entry) |
Hypothetical protein HI0047 [102092] (1 species) putative KHG/KDPG aldolase |
Species Haemophilus influenzae [TaxId:727] [102093] (1 PDB entry) |
KDPG aldolase [51584] (3 species) |
Species Escherichia coli [TaxId:562] [51585] (7 PDB entries) |
Species Pseudomonas putida [TaxId:303] [102091] (1 PDB entry) |
Species Thermotoga maritima [TaxId:2336] [110357] (2 PDB entries) Uniprot Q9WXS1 |
N-acetylneuraminate lyase [51571] (2 species) |
Species Escherichia coli [TaxId:562] [51572] (4 PDB entries) |
Species Haemophilus influenzae [TaxId:727] [51573] (6 PDB entries) |
Putative aldolase YihT [110358] (1 species) |
Species Salmonella typhimurium [TaxId:90371] [110359] (1 PDB entry) Uniprot Q9L7R9 |
Transaldolase [51588] (3 species) probably related to class I aldolases by a circular permutation |
Species Escherichia coli [TaxId:562] [51589] (7 PDB entries) |
Species Human (Homo sapiens) [TaxId:9606] [51590] (1 PDB entry) |
Species Mouse (Mus musculus) [TaxId:10090] [141835] (2 PDB entries) Uniprot Q93092 13-331 |
Type I 3-dehydroquinate dehydratase [51586] (2 species) |
Species Salmonella typhi [TaxId:90370] [51587] (3 PDB entries) |
Species Staphylococcus aureus [TaxId:1280] [117378] (2 PDB entries) Uniprot Q6GII7 |
Timeline for Family c.1.10.1: Class I aldolase: