Lineage for Family c.1.10.1: Class I aldolase

  1. Root: SCOP 1.71
  2. 570216Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
  3. 570217Fold c.1: TIM beta/alpha-barrel [51350] (32 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 572455Superfamily c.1.10: Aldolase [51569] (6 families) (S)
    Common fold covers whole protein structure
  5. 572456Family c.1.10.1: Class I aldolase [51570] (12 proteins)
    the catalytic lysine forms schiff-base intermediate with substrate
    possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels

Proteins:

  1. 5724572-keto-3-deoxy gluconate aldolase Eda [110360] (1 species)
  2. 572475Archaeal fructose 1,6-bisphosphate aldolase [102088] (1 species)
  3. 572507Decameric fructose-6-phosphate aldolase/transaldolase [75085] (2 species)
    forms helix-swapped pentamers
    1. 572508Species Escherichia coli [TaxId:562] [75086] (1 PDB entry)
    2. 572519Species Thermotoga maritima [TaxId:243274] [117379] (1 PDB entry)
  4. 572540Deoxyribose-phosphate aldolase DeoC [69394] (5 species)
    1. 572541Species Aquifex aeolicus [TaxId:63363] [82271] (1 PDB entry)
    2. 572544Species Archaeon Aeropyrum pernix [TaxId:56636] [89493] (1 PDB entry)
    3. 572547Species Escherichia coli [TaxId:562] [69395] (4 PDB entries)
    4. 572556Species Thermotoga maritima [TaxId:243274] [82270] (1 PDB entry)
      TM1559
    5. 572559Species Thermus thermophilus [TaxId:274] [89492] (2 PDB entries)
  5. 572568Dihydrodipicolinate synthase [51574] (2 species)
    1. 572569Species Escherichia coli [TaxId:562] [51575] (4 PDB entries)
    2. 572578Species Thermotoga maritima [TaxId:243274] [102090] (1 PDB entry)
  6. 572581Fructose-1,6-bisphosphate aldolase [51576] (8 species)
    1. 572582Species Drosophila melanogaster [TaxId:7227] [51579] (1 PDB entry)
    2. 572587Species Human (Homo sapiens), liver isozyme [TaxId:9606] [51578] (1 PDB entry)
    3. 572606Species Human (Homo sapiens), muscle isozyme [TaxId:9606] [51577] (3 PDB entries)
    4. 572610Species Plasmodium falciparum [51581] (1 PDB entry)
    5. 572613Species Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId:9986] [63920] (1 PDB entry)
    6. 572618Species Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId:9986] [51580] (7 PDB entries)
    7. 572647Species Trypanosome (Leishmania mexicana) [TaxId:5665] [51582] (1 PDB entry)
    8. 572652Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [51583] (1 PDB entry)
  7. 572654Hypothetical protein HI0047 [102092] (1 species)
    putative KHG/KDPG aldolase
  8. 572662KDPG aldolase [51584] (3 species)
    1. 572663Species Escherichia coli [TaxId:562] [51585] (4 PDB entries)
    2. 572676Species Pseudomonas putida [TaxId:303] [102091] (1 PDB entry)
    3. 572678Species Thermotoga maritima [TaxId:243274] [110357] (1 PDB entry)
  9. 572682N-acetylneuraminate lyase [51571] (2 species)
    1. 572683Species Escherichia coli [TaxId:562] [51572] (4 PDB entries)
    2. 572700Species Haemophilus influenzae [TaxId:727] [51573] (6 PDB entries)
  10. 572719Putative aldolase YihT [110358] (1 species)
  11. 572722Transaldolase [51588] (2 species)
    probably related to class I aldolases by a circular permutation
    1. 572723Species Escherichia coli [TaxId:562] [51589] (7 PDB entries)
    2. 572738Species Human (Homo sapiens) [TaxId:9606] [51590] (1 PDB entry)
  12. 572741Type I 3-dehydroquinate dehydratase [51586] (2 species)
    1. 572742Species Salmonella typhi [TaxId:90370] [51587] (3 PDB entries)
    2. 572750Species Staphylococcus aureus [TaxId:1280] [117378] (2 PDB entries)

More info for Family c.1.10.1: Class I aldolase

Timeline for Family c.1.10.1: Class I aldolase: