SCOP 1.71: Family c.1.10.1: Class I aldolase

Lineage for Family c.1.10.1: Class I aldolase

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (32 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.10: Aldolase [51569] (6 families)
   Common fold covers whole protein structure

5. Family c.1.10.1: Class I aldolase [51570] (12 proteins)
   the catalytic lysine forms schiff-base intermediate with substrate
   possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels

Proteins:

1. 2-keto-3-deoxy gluconate aldolase Eda [110360] (1 species)

   • Species Sulfolobus solfataricus [TaxId:2287] [110361] (4 PDB entries)

2. Archaeal fructose 1,6-bisphosphate aldolase [102088] (1 species)

   • Species Archaeon Thermoproteus tenax [TaxId:2271] [102089] (3 PDB entries)

3. Decameric fructose-6-phosphate aldolase/transaldolase [75085] (2 species)
   forms helix-swapped pentamers

   1. Species Escherichia coli [TaxId:562] [75086] (1 PDB entry)

   2. Species Thermotoga maritima [TaxId:243274] [117379] (1 PDB entry)

4. Deoxyribose-phosphate aldolase DeoC [69394] (5 species)

   1. Species Aquifex aeolicus [TaxId:63363] [82271] (1 PDB entry)

   2. Species Archaeon Aeropyrum pernix [TaxId:56636] [89493] (1 PDB entry)

   3. Species Escherichia coli [TaxId:562] [69395] (4 PDB entries)

   4. Species Thermotoga maritima [TaxId:243274] [82270] (1 PDB entry)
      TM1559

   5. Species Thermus thermophilus [TaxId:274] [89492] (2 PDB entries)

5. Dihydrodipicolinate synthase [51574] (2 species)

   1. Species Escherichia coli [TaxId:562] [51575] (4 PDB entries)

   2. Species Thermotoga maritima [TaxId:243274] [102090] (1 PDB entry)

6. Fructose-1,6-bisphosphate aldolase [51576] (8 species)

   1. Species Drosophila melanogaster [TaxId:7227] [51579] (1 PDB entry)

   2. Species Human (Homo sapiens), liver isozyme [TaxId:9606] [51578] (1 PDB entry)

   3. Species Human (Homo sapiens), muscle isozyme [TaxId:9606] [51577] (3 PDB entries)

   4. Species Plasmodium falciparum [51581] (1 PDB entry)

   5. Species Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId:9986] [63920] (1 PDB entry)

   6. Species Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId:9986] [51580] (7 PDB entries)

   7. Species Trypanosome (Leishmania mexicana) [TaxId:5665] [51582] (1 PDB entry)

   8. Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [51583] (1 PDB entry)

7. Hypothetical protein HI0047 [102092] (1 species)
   putative KHG/KDPG aldolase

   • Species Haemophilus influenzae [TaxId:727] [102093] (1 PDB entry)

8. KDPG aldolase [51584] (3 species)

   1. Species Escherichia coli [TaxId:562] [51585] (4 PDB entries)

   2. Species Pseudomonas putida [TaxId:303] [102091] (1 PDB entry)

   3. Species Thermotoga maritima [TaxId:243274] [110357] (1 PDB entry)

9. N-acetylneuraminate lyase [51571] (2 species)

   1. Species Escherichia coli [TaxId:562] [51572] (4 PDB entries)

   2. Species Haemophilus influenzae [TaxId:727] [51573] (6 PDB entries)

10. Putative aldolase YihT [110358] (1 species)

    • Species Salmonella typhimurium [TaxId:90371] [110359] (1 PDB entry)

11. Transaldolase [51588] (2 species)
    probably related to class I aldolases by a circular permutation

    1. Species Escherichia coli [TaxId:562] [51589] (7 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [51590] (1 PDB entry)

12. Type I 3-dehydroquinate dehydratase [51586] (2 species)

    1. Species Salmonella typhi [TaxId:90370] [51587] (3 PDB entries)

    2. Species Staphylococcus aureus [TaxId:1280] [117378] (2 PDB entries)

More info for Family c.1.10.1: Class I aldolase

Timeline for Family c.1.10.1: Class I aldolase:

• Family c.1.10.1: Class I aldolase first appeared (with stable ids) in SCOP 1.55
  
• Family c.1.10.1: Class I aldolase appears in SCOP 1.69
  
• Family c.1.10.1: Class I aldolase appears in SCOP 1.73
  
• Family c.1.10.1: Class I aldolase appears in the current release, SCOPe 2.08