Lineage for Family c.1.10.1: Class I aldolase

  1. Root: SCOPe 2.08
  2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. Superfamily c.1.10: Aldolase [51569] (9 families) (S)
    Common fold covers whole protein structure
  5. Family c.1.10.1: Class I aldolase [51570] (13 proteins)
    the catalytic lysine forms schiff-base intermediate with substrate
    possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels

Proteins:

  1. 2-keto-3-deoxy gluconate aldolase Eda [110360] (1 species)
  2. Archaeal fructose 1,6-bisphosphate aldolase [102088] (1 species)
  3. Decameric fructose-6-phosphate aldolase/transaldolase [75085] (3 species)
    forms helix-swapped pentamers
    1. Species Escherichia coli [TaxId:562] [75086] (1 PDB entry)
    2. Species Thermotoga maritima [TaxId:2336] [117379] (1 PDB entry)
      Uniprot Q9WYD1
    3. Species Thermus thermophilus [TaxId:274] [141836] (1 PDB entry)
      Uniprot Q5SJE8 1-211
      clear orthologue of the E.coli protein; annotated as transaldolase in UniProt
  4. Deoxyribose-phosphate aldolase DeoC [69394] (6 species)
    1. Species Aeropyrum pernix [TaxId:56636] [89493] (1 PDB entry)
    2. Species Aquifex aeolicus [TaxId:63363] [82271] (1 PDB entry)
    3. Species Escherichia coli [TaxId:562] [69395] (4 PDB entries)
      Uniprot P00882
    4. Species Pyrobaculum aerophilum [TaxId:13773] [141830] (1 PDB entry)
      Uniprot Q8ZXK7 1-226
    5. Species Thermotoga maritima [TaxId:2336] [82270] (3 PDB entries)
      TM1559
    6. Species Thermus thermophilus [TaxId:274] [89492] (2 PDB entries)
  5. Dihydrodipicolinate synthase [51574] (13 species)
    1. Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [141832] (2 PDB entries)
      Uniprot Q81WN7 1-292
    2. Species Campylobacter jejuni [TaxId:192222] [189204] (3 PDB entries)
    3. Species Clostridium botulinum [TaxId:441770] [189380] (1 PDB entry)
    4. Species Clostridium botulinum [TaxId:441771] [189048] (2 PDB entries)
    5. Species Corynebacterium glutamicum [TaxId:1718] [188663] (1 PDB entry)
    6. Species Escherichia coli K-12 [TaxId:83333] [188673] (3 PDB entries)
    7. Species Escherichia coli [TaxId:562] [51575] (17 PDB entries)
    8. Species Escherichia coli [TaxId:585034] [323806] (2 PDB entries)
    9. Species Methanocaldococcus jannaschii [TaxId:243232] [188258] (1 PDB entry)
    10. Species Mycobacterium tuberculosis [TaxId:1773] [141831] (2 PDB entries)
      Uniprot P63945 5-300
    11. Species Pseudomonas aeruginosa [TaxId:287] [189992] (1 PDB entry)
    12. Species Pseudomonas aeruginosa, PA01 [TaxId:208964] [189575] (2 PDB entries)
    13. Species Thermotoga maritima [TaxId:2336] [102090] (1 PDB entry)
  6. Fructose-1,6-bisphosphate aldolase [51576] (11 species)
    1. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [51579] (1 PDB entry)
    2. Species Human (Homo sapiens), brain isozyme [TaxId:9606] [141834] (1 PDB entry)
      Uniprot P09972 2-343
    3. Species Human (Homo sapiens), liver isozyme [TaxId:9606] [51578] (2 PDB entries)
    4. Species Human (Homo sapiens), muscle isozyme [TaxId:9606] [51577] (4 PDB entries)
    5. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [51581] (1 PDB entry)
    6. Species Plasmodium yoelii yoelii [TaxId:73239] [141833] (1 PDB entry)
      Uniprot Q7RMC9 3-258
    7. Species Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId:9986] [63920] (1 PDB entry)
    8. Species Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId:9986] [51580] (33 PDB entries)
    9. Species Trypanosome (Leishmania mexicana) [TaxId:5665] [51582] (1 PDB entry)
    10. Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [51583] (1 PDB entry)
    11. Species Human (Homo sapiens) [TaxId:9606] [254964] (6 PDB entries)
  7. Hypothetical protein HI0047 [102092] (1 species)
    putative KHG/KDPG aldolase
  8. KDPG aldolase [51584] (3 species)
    1. Species Escherichia coli [TaxId:562] [51585] (7 PDB entries)
    2. Species Pseudomonas putida [TaxId:303] [102091] (1 PDB entry)
    3. Species Thermotoga maritima [TaxId:2336] [110357] (1 PDB entry)
      Uniprot Q9WXS1
  9. N-acetylneuraminate lyase [51571] (2 species)
    1. Species Escherichia coli [TaxId:562] [51572] (4 PDB entries)
    2. Species Haemophilus influenzae [TaxId:727] [51573] (6 PDB entries)
  10. Putative aldolase YihT [110358] (1 species)
  11. Transaldolase [51588] (3 species)
    probably related to class I aldolases by a circular permutation
    1. Species Escherichia coli [TaxId:562] [51589] (7 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [51590] (1 PDB entry)
    3. Species Mouse (Mus musculus) [TaxId:10090] [141835] (1 PDB entry)
      Uniprot Q93092 13-331
  12. Type I 3-dehydroquinate dehydratase [51586] (4 species)
    1. Species Salmonella enterica [TaxId:90370] [260153] (11 PDB entries)
    2. Species Salmonella typhi [TaxId:90370] [51587] (3 PDB entries)
    3. Species Staphylococcus aureus [TaxId:1280] [117378] (2 PDB entries)
      Uniprot Q6GII7
    4. Species Streptococcus pyogenes [TaxId:301447] [225216] (1 PDB entry)
  13. automated matches [190095] (28 species)
    not a true protein
    1. Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [189130] (1 PDB entry)
    2. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [383110] (2 PDB entries)
    3. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [188824] (1 PDB entry)
    4. Species Campylobacter jejuni [TaxId:192222] [377840] (1 PDB entry)
    5. Species Campylobacter jejuni [TaxId:197] [377859] (1 PDB entry)
    6. Species Colwellia psychrerythraea [TaxId:167879] [312672] (1 PDB entry)
    7. Species Colwellia psychrerythraea [TaxId:28229] [312816] (1 PDB entry)
    8. Species Escherichia coli K-12 [TaxId:83333] [225841] (10 PDB entries)
    9. Species Escherichia coli [TaxId:469008] [189446] (6 PDB entries)
    10. Species Escherichia coli [TaxId:562] [189174] (10 PDB entries)
    11. Species Escherichia coli [TaxId:83333] [277890] (11 PDB entries)
    12. Species Human (Homo sapiens) [TaxId:9606] [254965] (1 PDB entry)
    13. Species Mouse (Mus musculus) [TaxId:10090] [187041] (2 PDB entries)
    14. Species Mycobacterium tuberculosis [TaxId:1773] [189568] (1 PDB entry)
    15. Species Oleispira antarctica [TaxId:188908] [189374] (1 PDB entry)
    16. Species Oryctolagus cuniculus [311133] (1 PDB entry)
    17. Species Pasteurella multocida [TaxId:1169409] [228765] (5 PDB entries)
    18. Species Pseudomonas aeruginosa [TaxId:287] [372682] (1 PDB entry)
    19. Species Pseudomonas aeruginosa, PA01 [TaxId:208964] [189421] (1 PDB entry)
    20. Species Pyrobaculum aerophilum [TaxId:13773] [187314] (1 PDB entry)
    21. Species Salmonella enterica [TaxId:99287] [189300] (4 PDB entries)
    22. Species Salmonella typhimurium [TaxId:90371] [189452] (5 PDB entries)
    23. Species Staphylococcus aureus [TaxId:1280] [383730] (1 PDB entry)
    24. Species Sulfolobus solfataricus [TaxId:2287] [195677] (7 PDB entries)
    25. Species Thermoplasma acidophilum [TaxId:273075] [189712] (12 PDB entries)
    26. Species Thermoproteus tenax [TaxId:2271] [186816] (2 PDB entries)
    27. Species Thermotoga maritima [TaxId:2336] [186818] (3 PDB entries)
    28. Species Toxoplasma gondii [TaxId:5811] [259539] (2 PDB entries)

More info for Family c.1.10.1: Class I aldolase

Timeline for Family c.1.10.1: Class I aldolase: