Lineage for Family c.1.10.1: Class I aldolase

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2413227Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2420459Superfamily c.1.10: Aldolase [51569] (9 families) (S)
    Common fold covers whole protein structure
  5. 2420460Family c.1.10.1: Class I aldolase [51570] (13 protein domains)
    the catalytic lysine forms schiff-base intermediate with substrate
    possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels

Protein Domains:

  1. 24204612-keto-3-deoxy gluconate aldolase Eda [110360] (1 species)
  2. 2420479Archaeal fructose 1,6-bisphosphate aldolase [102088] (1 species)
  3. 2420522Decameric fructose-6-phosphate aldolase/transaldolase [75085] (3 species)
    forms helix-swapped pentamers
    1. 2420523Species Escherichia coli [TaxId:562] [75086] (1 PDB entry)
    2. 2420534Species Thermotoga maritima [TaxId:2336] [117379] (1 PDB entry)
      Uniprot Q9WYD1
    3. 2420555Species Thermus thermophilus [TaxId:274] [141836] (1 PDB entry)
      Uniprot Q5SJE8 1-211
      clear orthologue of the E.coli protein; annotated as transaldolase in UniProt
  4. 2420557Deoxyribose-phosphate aldolase DeoC [69394] (6 species)
    1. 2420558Species Aeropyrum pernix [TaxId:56636] [89493] (1 PDB entry)
    2. 2420561Species Aquifex aeolicus [TaxId:63363] [82271] (1 PDB entry)
    3. 2420564Species Escherichia coli [TaxId:562] [69395] (4 PDB entries)
      Uniprot P00882
    4. 2420573Species Pyrobaculum aerophilum [TaxId:13773] [141830] (1 PDB entry)
      Uniprot Q8ZXK7 1-226
    5. 2420575Species Thermotoga maritima [TaxId:2336] [82270] (3 PDB entries)
      TM1559
    6. 2420582Species Thermus thermophilus [TaxId:274] [89492] (2 PDB entries)
  5. 2420591Dihydrodipicolinate synthase [51574] (13 species)
    1. 2420592Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [141832] (2 PDB entries)
      Uniprot Q81WN7 1-292
    2. 2420601Species Campylobacter jejuni [TaxId:192222] [189204] (3 PDB entries)
    3. 2420614Species Clostridium botulinum [TaxId:441770] [189380] (1 PDB entry)
    4. 2420617Species Clostridium botulinum [TaxId:441771] [189048] (2 PDB entries)
    5. 2420620Species Corynebacterium glutamicum [TaxId:1718] [188663] (1 PDB entry)
    6. 2420623Species Escherichia coli K-12 [TaxId:83333] [188673] (3 PDB entries)
    7. 2420630Species Escherichia coli [TaxId:562] [51575] (16 PDB entries)
    8. 2420663Species Escherichia coli [TaxId:585034] [323806] (2 PDB entries)
    9. 2420668Species Methanocaldococcus jannaschii [TaxId:243232] [188258] (1 PDB entry)
    10. 2420673Species Mycobacterium tuberculosis [TaxId:1773] [141831] (2 PDB entries)
      Uniprot P63945 5-300
    11. 2420683Species Pseudomonas aeruginosa [TaxId:287] [189992] (1 PDB entry)
    12. 2420686Species Pseudomonas aeruginosa, PA01 [TaxId:208964] [189575] (2 PDB entries)
    13. 2420691Species Thermotoga maritima [TaxId:2336] [102090] (1 PDB entry)
  6. 2420694Fructose-1,6-bisphosphate aldolase [51576] (11 species)
    1. 2420695Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [51579] (1 PDB entry)
    2. 2420700Species Human (Homo sapiens) [TaxId:9606] [254964] (2 PDB entries)
    3. 2420716Species Human (Homo sapiens), brain isozyme [TaxId:9606] [141834] (1 PDB entry)
      Uniprot P09972 2-343
    4. 2420718Species Human (Homo sapiens), liver isozyme [TaxId:9606] [51578] (2 PDB entries)
    5. 2420738Species Human (Homo sapiens), muscle isozyme [TaxId:9606] [51577] (4 PDB entries)
    6. 2420746Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [51581] (1 PDB entry)
    7. 2420749Species Plasmodium yoelii yoelii [TaxId:73239] [141833] (1 PDB entry)
      Uniprot Q7RMC9 3-258
    8. 2420752Species Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId:9986] [63920] (1 PDB entry)
    9. 2420757Species Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId:9986] [51580] (31 PDB entries)
    10. Species Trypanosome (Leishmania mexicana) [TaxId:5665] [51582] (1 PDB entry)
    11. 2420884Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [51583] (1 PDB entry)
  7. 2420886Hypothetical protein HI0047 [102092] (1 species)
    putative KHG/KDPG aldolase
  8. 2420894KDPG aldolase [51584] (3 species)
    1. 2420895Species Escherichia coli [TaxId:562] [51585] (7 PDB entries)
    2. 2420915Species Pseudomonas putida [TaxId:303] [102091] (1 PDB entry)
    3. 2420917Species Thermotoga maritima [TaxId:2336] [110357] (1 PDB entry)
      Uniprot Q9WXS1
  9. 2420921N-acetylneuraminate lyase [51571] (2 species)
    1. 2420922Species Escherichia coli [TaxId:562] [51572] (4 PDB entries)
    2. 2420939Species Haemophilus influenzae [TaxId:727] [51573] (6 PDB entries)
  10. 2420958Putative aldolase YihT [110358] (1 species)
  11. 2420961Transaldolase [51588] (3 species)
    probably related to class I aldolases by a circular permutation
    1. 2420962Species Escherichia coli [TaxId:562] [51589] (7 PDB entries)
    2. 2420977Species Human (Homo sapiens) [TaxId:9606] [51590] (1 PDB entry)
    3. 2420980Species Mouse (Mus musculus) [TaxId:10090] [141835] (1 PDB entry)
      Uniprot Q93092 13-331
  12. 2420982Type I 3-dehydroquinate dehydratase [51586] (4 species)
    1. 2420983Species Salmonella enterica [TaxId:90370] [260153] (5 PDB entries)
    2. 2420995Species Salmonella typhi [TaxId:90370] [51587] (3 PDB entries)
    3. 2421003Species Staphylococcus aureus [TaxId:1280] [117378] (2 PDB entries)
      Uniprot Q6GII7
    4. 2421008Species Streptococcus pyogenes [TaxId:301447] [225216] (1 PDB entry)
  13. 2421010automated matches [190095] (23 species)
    not a true protein
    1. 2421011Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [189130] (1 PDB entry)
    2. 2421016Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [188824] (1 PDB entry)
    3. 2421019Species Colwellia psychrerythraea [TaxId:167879] [312672] (1 PDB entry)
    4. 2421024Species Colwellia psychrerythraea [TaxId:28229] [312816] (1 PDB entry)
    5. 2421027Species Escherichia coli K-12 [TaxId:83333] [225841] (10 PDB entries)
    6. 2421066Species Escherichia coli [TaxId:469008] [189446] (6 PDB entries)
    7. 2421086Species Escherichia coli [TaxId:562] [189174] (7 PDB entries)
    8. 2421107Species Escherichia coli [TaxId:83333] [277890] (10 PDB entries)
    9. 2421168Species Human (Homo sapiens) [TaxId:9606] [254965] (1 PDB entry)
    10. 2421180Species Mouse (Mus musculus) [TaxId:10090] [187041] (2 PDB entries)
    11. 2421184Species Mycobacterium tuberculosis [TaxId:1773] [189568] (1 PDB entry)
    12. 2421191Species Oleispira antarctica [TaxId:188908] [189374] (1 PDB entry)
    13. 2421193Species Oryctolagus cuniculus [311133] (1 PDB entry)
    14. 2421198Species Pasteurella multocida [TaxId:1169409] [228765] (5 PDB entries)
    15. 2421219Species Pseudomonas aeruginosa, PA01 [TaxId:208964] [189421] (1 PDB entry)
    16. 2421222Species Pyrobaculum aerophilum [TaxId:13773] [187314] (1 PDB entry)
    17. 2421224Species Salmonella enterica [TaxId:99287] [189300] (4 PDB entries)
    18. 2421236Species Salmonella typhimurium [TaxId:90371] [189452] (5 PDB entries)
    19. 2421248Species Sulfolobus solfataricus [TaxId:2287] [195677] (1 PDB entry)
    20. 2421251Species Thermoplasma acidophilum [TaxId:273075] [189712] (6 PDB entries)
    21. 2421282Species Thermoproteus tenax [TaxId:2271] [186816] (2 PDB entries)
    22. 2421302Species Thermotoga maritima [TaxId:2336] [186818] (3 PDB entries)
    23. 2421319Species Toxoplasma gondii [TaxId:5811] [259539] (2 PDB entries)

More info for Family c.1.10.1: Class I aldolase

Timeline for Family c.1.10.1: Class I aldolase: