SCOP 1.69: Superfamily c.1.10: Aldolase

Lineage for Superfamily c.1.10: Aldolase

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (31 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.10: Aldolase [51569] (6 families)
   Common fold covers whole protein structure

Families:

1. c.1.10.1: Class I aldolase [51570] (12 proteins)
   the catalytic lysine forms schiff-base intermediate with substrate
   possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels

2. c.1.10.2: Class II FBP aldolase [51591] (2 proteins)
   metal-dependent

3. c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51594] (1 protein)
   hybrid of classes I and II aldolase

4. c.1.10.4: Class I DAHP synthetase [51599] (2 proteins)

5. c.1.10.5: HMGL-like (Pfam 00682) [89494] (3 proteins)

6. c.1.10.6: NeuB-like (Pfam 03102) [110368] (1 protein)

More info for Superfamily c.1.10: Aldolase

Timeline for Superfamily c.1.10: Aldolase:

• Superfamily c.1.10: Aldolase first appeared (with stable ids) in SCOP 1.55
  
• Superfamily c.1.10: Aldolase appears in SCOP 1.67
  
• Superfamily c.1.10: Aldolase appears in SCOP 1.71
  
• Superfamily c.1.10: Aldolase appears in the current release, SCOPe 2.08