SCOPe 2.08: Protein: Adenosine deaminase (ADA)

Lineage for Protein: Adenosine deaminase (ADA)

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites

Superfamily c.1.9: Metallo-dependent hydrolases [51556] (19 families)
the beta-sheet barrel is similarly distorted and capped by a C-terminal helix
has transition metal ions bound inside the barrel
Family c.1.9.1: Adenosine/AMP deaminase [51557] (3 proteins)
Protein Adenosine deaminase (ADA) [51558] (4 species)
Common fold covers the whole protein structure

Species:

Cow (Bos taurus) [TaxId:9913] [82257] (13 PDB entries)
Uniprot P56658 3-350 ! Uniprot P56658
1. Domain for 1krm:
  - Domain d1krma_: 1krm A: [77513]
    complexed with prh, zn
2. Domain for 1ndv:
  - Domain d1ndva_: 1ndv A: [91824]
    complexed with fr0, zn
3. Domain for 1ndw:
  - Domain d1ndwa_: 1ndw A: [91825]
    complexed with fr2, zn
4. Domain for 1ndy:
  - Domain d1ndya_: 1ndy A: [91826]
    complexed with fr3, zn
5. Domain for 1ndz:
  - Domain d1ndza_: 1ndz A: [91827]
    complexed with fr5, zn
6. Domain for 1o5r:
  - Domain d1o5ra_: 1o5r A: [103890]
    complexed with fr9, zn
7. Domain for 1qxl:
  - Domain d1qxla_: 1qxl A: [104644]
    complexed with fr8, zn
8. Domain for 1uml:
  - Domain d1umla_: 1uml A: [107957]
    complexed with fr4, zn
9. Domain for 1v78:
  - Domain d1v78a_: 1v78 A: [303201]
    automated match to d1ndya_
    complexed with fr6, zn
10. Domain for 1v79:
  - Domain d1v79a_: 1v79 A: [113559]
    complexed with fr7, zn
11. Domain for 1v7a:
  - Domain d1v7aa_: 1v7a A: [113560]
    complexed with frc, zn
12. Domains for 1w1i:
  1. Domain d1w1ie_: 1w1i E: [109051]
    Other proteins in same PDB: d1w1ia1, d1w1ia2, d1w1ib1, d1w1ib2, d1w1ic1, d1w1ic2, d1w1id1, d1w1id2
    complexed with nag, zn
  2. Domain d1w1if_: 1w1i F: [109052]
    Other proteins in same PDB: d1w1ia1, d1w1ia2, d1w1ib1, d1w1ib2, d1w1ic1, d1w1ic2, d1w1id1, d1w1id2
    complexed with nag, zn
  3. Domain d1w1ig_: 1w1i G: [109053]
    Other proteins in same PDB: d1w1ia1, d1w1ia2, d1w1ib1, d1w1ib2, d1w1ic1, d1w1ic2, d1w1id1, d1w1id2
    complexed with nag, zn
  4. Domain d1w1ih_: 1w1i H: [109054]
    Other proteins in same PDB: d1w1ia1, d1w1ia2, d1w1ib1, d1w1ib2, d1w1ic1, d1w1ic2, d1w1id1, d1w1id2
    complexed with nag, zn
13. Domains for 2bgn:
  1. Domain d2bgne1: 2bgn E:4-355 [128492]
    Other proteins in same PDB: d2bgna1, d2bgna2, d2bgnb1, d2bgnb2, d2bgnc1, d2bgnc2, d2bgnd1, d2bgnd2
    automatically matched to d1w1ie_
    complexed with nag, zn
  2. Domain d2bgnf1: 2bgn F:4-355 [128493]
    Other proteins in same PDB: d2bgna1, d2bgna2, d2bgnb1, d2bgnb2, d2bgnc1, d2bgnc2, d2bgnd1, d2bgnd2
    automatically matched to d1w1ie_
    complexed with nag, zn
  3. Domain d2bgng1: 2bgn G:4-355 [128494]
    Other proteins in same PDB: d2bgna1, d2bgna2, d2bgnb1, d2bgnb2, d2bgnc1, d2bgnc2, d2bgnd1, d2bgnd2
    automatically matched to d1w1ie_
    complexed with nag, zn
  4. Domain d2bgnh1: 2bgn H:4-355 [128495]
    Other proteins in same PDB: d2bgna1, d2bgna2, d2bgnb1, d2bgnb2, d2bgnc1, d2bgnc2, d2bgnd1, d2bgnd2
    automatically matched to d1w1ie_
    complexed with nag, zn
Human (Homo sapiens) [TaxId:9606] [224876] (1 PDB entry)
- Domain for 3iar:
  - Domain d3iara1: 3iar A:5-363 [178216]
    Other proteins in same PDB: d3iara2
    automated match to d1w1ie_
    complexed with 3d1, gol, ni, no3
Mouse (Mus musculus) [TaxId:10090] [51559] (10 PDB entries)
1. Domains for 1a4l:
  1. Domain d1a4la_: 1a4l A: [29023]
    complexed with dcf, zn
  2. Domain d1a4lb_: 1a4l B: [29024]
    complexed with dcf, zn
  3. Domain d1a4lc_: 1a4l C: [29025]
    complexed with dcf, zn
  4. Domain d1a4ld_: 1a4l D: [29026]
    complexed with dcf, zn
2. Domains for 1a4m:
  1. Domain d1a4ma_: 1a4m A: [29014]
    complexed with prh, zn
  2. Domain d1a4mb_: 1a4m B: [29015]
    complexed with prh, zn
  3. Domain d1a4mc_: 1a4m C: [29016]
    complexed with prh, zn
  4. Domain d1a4md_: 1a4m D: [29017]
    complexed with prh, zn
3. Domain for 1add:
  - Domain d1adda_: 1add A: [29020]
    complexed with 1da, zn
4. Domain for 1fkw:
  - Domain d1fkwa_: 1fkw A: [29019]
    complexed with pur, zn
5. Domain for 1fkx:
  - Domain d1fkxa_: 1fkx A: [29018]
    complexed with prh, zn
6. Domain for 1uio:
  - Domain d1uioa_: 1uio A: [29021]
    complexed with hpr, zn; mutant
7. Domain for 1uip:
  - Domain d1uipa_: 1uip A: [29022]
    complexed with pur, zn; mutant
8. Domain for 2ada:
  - Domain d2adaa_: 2ada A: [29027]
    complexed with hpr, zn; mutant
9. Domains for 3mvi:
  1. Domain d3mvia_: 3mvi A: [213590]
    automated match to d1a4ma_
    complexed with gol, zn
  2. Domain d3mvib_: 3mvi B: [213591]
    automated match to d1a4ma_
    complexed with gol, zn
10. Domains for 3mvt:
  1. Domain d3mvta_: 3mvt A: [213609]
    automated match to d1a4ma_
    complexed with cl, gol
  2. Domain d3mvtc_: 3mvt C: [213610]
    automated match to d1a4ma_
    complexed with cl, gol
Plasmodium yoelii [TaxId:5861] [141799] (1 PDB entry)
Uniprot Q7RMV2 8-364
- Domain for 2amx:
  - Domain d2amxa1: 2amx A:20-376 [127024]
    Other proteins in same PDB: d2amxa2, d2amxb2, d2amxb3
    complexed with co, unx

More info for Protein Adenosine deaminase (ADA) from c.1.9.1: Adenosine/AMP deaminase

Timeline for Protein Adenosine deaminase (ADA) from c.1.9.1: Adenosine/AMP deaminase:

Protein Adenosine deaminase (ADA) from c.1.9.1: Adenosine/AMP deaminase first appeared (with stable ids) in SCOP 1.55, called Protein Adenosine deaminase (ADA) from c.1.9.1: Adenosine deaminase (ADA)
Protein Adenosine deaminase (ADA) from c.1.9.1: Adenosine/AMP deaminase appears in SCOPe 2.07