Lineage for Family c.1.8.1: Amylase, catalytic domain

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 968086Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 969862Superfamily c.1.8: (Trans)glycosidases [51445] (15 families) (S)
  5. 969863Family c.1.8.1: Amylase, catalytic domain [51446] (26 proteins)
    members of the family may contain various insert subdomains
    in alpha-amylases and closer relatives this domain is usually followed by a common all-beta domain

Proteins:

  1. 9698641,4-alpha-glucan branching enzyme, central domain [82244] (1 species)
  2. 9698704-alpha-glucanotransferase [75062] (1 species)
  3. 969876A4 beta-galactosidase [82246] (1 species)
    the catalytic domain is very similar to that of the bacterial beta-amylase; but contains a typical alpha-amylase extra domain
  4. 969880Amylomaltase MalQ [51478] (3 species)
    4-alpha-glucanotransferase; single-domain amylase with several insertions in the common fold
    1. 969881Species Aquifex aeolicus [TaxId:63363] [141770] (1 PDB entry)
      Uniprot O66937 1-485
    2. 969884Species Potato (Solanum tuberosum) [TaxId:4113] [141771] (1 PDB entry)
      Uniprot Q06801 54-576
    3. 969886Species Thermus aquaticus [TaxId:271] [51479] (4 PDB entries)
      synonym: Thermus thermophilus
  5. 969891Amylosucrase [69384] (1 species)
  6. 969903Animal alpha-amylase [51458] (3 species)
    contains Ca2+-binding subdomain, residues 100-170
    1. 969904Species Human (Homo sapiens) [TaxId:9606] [51460] (42 PDB entries)
      Uniprot P04746 16-511 ! SQ 04746
    2. 969948Species Pig (Sus scrofa) [TaxId:9823] [51459] (14 PDB entries)
    3. 969969Species Yellow mealworm (Tenebrio molitor), larva [TaxId:7067] [51461] (4 PDB entries)
  7. 969974Bacterial alpha-amylase [51447] (10 species)
    1. 969975Species Bacillus halmapalus [TaxId:79882] [141768] (3 PDB entries)
      Uniprot P19571 38-431
    2. 969979Species Bacillus licheniformis [TaxId:1402] [51448] (4 PDB entries)
    3. 969984Species Bacillus sp. 707 [TaxId:1416] [117366] (4 PDB entries)
      Uniprot P19571 38-518
    4. 969989Species Bacillus sp., ksm-k38 [TaxId:1409] [89463] (6 PDB entries)
    5. 969996Species Bacillus stearothermophilus [TaxId:1422] [51451] (1 PDB entry)
    6. 969998Species Bacillus subtilis [TaxId:1423] [51450] (2 PDB entries)
      Uniprot P00691
    7. 970001Species Chimera (Bacillus amyloliquefaciens) and (Bacillus licheniformis) [TaxId:1390] [63903] (4 PDB entries)
      the N-terminal 300 residues are from B. amyloliquefaciens
    8. 970006Species Halothermothrix orenii [TaxId:31909] [141767] (1 PDB entry)
      Uniprot Q8GPL8 28-436
    9. 970008Species Pseudoalteromonas haloplanktis [TaxId:228] [51449] (9 PDB entries)
    10. 970018Species Pyrococcus woesei [TaxId:2262] [89464] (3 PDB entries)
  8. 970022Bacterial beta-amylase [51485] (1 species)
    protein contains additional starch-binding domain
  9. 970056beta-Amylase [51481] (3 species)
    Common fold covers whole protein structure
    1. 970057Species Barley (Hordeum vulgare) [TaxId:4513] [51483] (1 PDB entry)
    2. 970059Species Soybean (Glycine max) [TaxId:3847] [51482] (18 PDB entries)
      Uniprot P10538
    3. 970084Species Sweet potato (Ipomoea batatas) [TaxId:4120] [51484] (1 PDB entry)
  10. 970086Cyclodextrin glycosyltransferase [51452] (6 species)
    contains two more all-beta domains, one is Immunoglobulin-like and the other is trasthyretin-like
    1. 970087Species Bacillus circulans, different strains [TaxId:1397] [51453] (36 PDB entries)
    2. 970128Species Bacillus sp. 1011, alkaliphilic [TaxId:1410] [51456] (8 PDB entries)
      Uniprot P05618
    3. 970145Species Bacillus stearothermophilus [TaxId:1422] [51454] (1 PDB entry)
    4. 970147Species Bacillus stearothermophilus, maltogenic alpha-amylase [TaxId:1422] [51455] (2 PDB entries)
    5. 970150Species Thermoanaerobacterium thermosulfurigenes, EM1 [TaxId:33950] [51457] (2 PDB entries)
    6. 970153Species Thermoanaerobacterium [TaxId:28895] [159380] (2 PDB entries)
  11. 970156Cyclomaltodextrinase, central domain [102058] (1 species)
    protein shares similar domain organization with maltogenic amylases but differs in the spatial arrangement of its domains
  12. 970160Fungal alpha-amylases [51462] (2 species)
    1. 970161Species Aspergillus niger, acid amylase [TaxId:5061] [51463] (1 PDB entry)
    2. 970163Species Aspergillus oryzae, Taka-amylase [TaxId:5062] [51464] (5 PDB entries)
  13. 970172G4-amylase (1,4-alpha-D-glucan maltotetrahydrolase) [51472] (1 species)
  14. 970183Glycosyltrehalose trehalohydrolase, central domain [51468] (2 species)
    contains an additional N-terminal domain
    1. 970184Species Deinococcus radiodurans [TaxId:1299] [141769] (9 PDB entries)
      Uniprot Q9RX51 111-528
    2. 970194Species Sulfolobus solfataricus, km1 [TaxId:2287] [51469] (2 PDB entries)
  15. 970197Isoamylase, central domain [51470] (1 species)
  16. 970200Isomaltulose synthase PalI [89466] (1 species)
  17. 970203Maltogenic amylase, central domain [51465] (4 species)
    contains an additional N-terminal domain
    1. 970204Species Bacillus sp., cyclomaltodextrinase [TaxId:1409] [75060] (1 PDB entry)
    2. 970207Species Thermoactinomyces vulgaris, TVAI [TaxId:2026] [75061] (9 PDB entries)
    3. 970218Species Thermoactinomyces vulgaris, TVAII [TaxId:2026] [51467] (16 PDB entries)
    4. 970251Species Thermus sp. [TaxId:275] [51466] (2 PDB entries)
  18. 970256Maltooligosyl trehalose synthase [82242] (1 species)
    elaborated with several large insertions in the common fold
  19. 970259Maltosyltransferase [63904] (1 species)
    similar to bacterial alpha-amylase; contains larger insertion domain
  20. 970263Melibiase [75064] (4 species)
    1. 970264Species Chicken (Gallus gallus) [TaxId:9031] [75065] (2 PDB entries)
      alpha-N-acetylgalactosaminidase
    2. 970267Species Human (Homo sapiens) [TaxId:9606] [102062] (2 PDB entries)
      alpha-galactosidase A
    3. 970272Species Rice (Oryza sativa) [TaxId:4530] [89468] (1 PDB entry)
      alpha-galactosidase
    4. 970274Species Trichoderma reesei [TaxId:51453] [110349] (2 PDB entries)
      Alpha-galactosidase agl1
      Uniprot Q92456
  21. 970277Neopullulanase, central domain [82240] (1 species)
    homologous to Maltogenic amylase
  22. 970287Oligo-1,6, glucosidase [51476] (1 species)
  23. 970290Plant alpha-amylase [51474] (2 species)
    1. 970291Species Barley (Hordeum vulgare), AMY1 isozyme [TaxId:4513] [89465] (8 PDB entries)
    2. 970302Species Barley (Hordeum vulgare), seeds, AMY2 isozyme [TaxId:4513] [51475] (3 PDB entries)
  24. 970307Pullulanase PulA [159381] (1 species)
  25. 970312Sucrose phosphorylase [102060] (1 species)
    sequence and close structural relationship to amylosucrase; variations in the C-terminal domain fold
  26. 970320automated matches [190099] (3 species)
    not a true protein
    1. 970321Species Soybean (Glycine max) [TaxId:3847] [186821] (2 PDB entries)
    2. 970324Species Thermus brockianus [TaxId:56956] [189542] (1 PDB entry)
    3. 970326Species Thermus thermophilus [TaxId:274] [188525] (3 PDB entries)

More info for Family c.1.8.1: Amylase, catalytic domain

Timeline for Family c.1.8.1: Amylase, catalytic domain: