Lineage for Family c.1.8.1: Amylase, catalytic domain

  1. Root: SCOP 1.71
  2. 570216Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
  3. 570217Fold c.1: TIM beta/alpha-barrel [51350] (32 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 571086Superfamily c.1.8: (Trans)glycosidases [51445] (13 families) (S)
  5. 571087Family c.1.8.1: Amylase, catalytic domain [51446] (24 proteins)
    members of the family may contain various insert subdomains
    in alpha-amylases and closer relatives this domain is usually followed by a common all-beta domain

Proteins:

  1. 5710881,4-alpha-glucan branching enzyme, central domain [82244] (1 species)
  2. 5710944-alpha-glucanotransferase [75062] (1 species)
  3. 571100A4 beta-galactosidase [82246] (1 species)
    the catalytic domain is very similar to that of the bacterial beta-amylase; but contains a typical alpha-amylase extra domain
  4. 571104Amylomaltase MalQ [51478] (1 species)
    4-alpha-glucanotransferase; single-domain amylase with several insertions in the common fold
  5. 571110Amylosucrase [69384] (1 species)
  6. 571121Animal alpha-amylase [51458] (3 species)
    contains Ca2+-binding subdomain, residues 100-170
    1. 571122Species Human (Homo sapiens) [TaxId:9606] [51460] (27 PDB entries)
    2. 571150Species Pig (Sus scrofa) [TaxId:9823] [51459] (12 PDB entries)
    3. 571169Species Yellow mealworm (Tenebrio molitor), larva [TaxId:7067] [51461] (4 PDB entries)
  7. 571174Bacterial alpha-amylase [51447] (8 species)
    1. 571175Species Archaeon Pyrococcus woesei [TaxId:2262] [89464] (3 PDB entries)
    2. 571179Species Bacillus licheniformis [TaxId:1402] [51448] (4 PDB entries)
    3. 571184Species Bacillus sp. strain 707 [117366] (2 PDB entries)
    4. 571187Species Bacillus sp., ksm-k38 [TaxId:1409] [89463] (6 PDB entries)
    5. 571194Species Bacillus stearothermophilus [TaxId:1422] [51451] (1 PDB entry)
    6. 571196Species Bacillus subtilis [TaxId:1423] [51450] (2 PDB entries)
    7. 571199Species Chimera (Bacillus amyloliquefaciens) and (Bacillus licheniformis) [TaxId:1390] [63903] (4 PDB entries)
      the N-terminal 300 residues are from B. amyloliquefaciens
    8. 571204Species Pseudoalteromonas haloplanctis (Alteromonas haloplanctis) [51449] (9 PDB entries)
  8. 571214Bacterial beta-amylase [51485] (1 species)
    protein contains additional starch-binding domain
  9. 571244beta-Amylase [51481] (3 species)
    Common fold covers whole protein structure
    1. 571245Species Barley (Hordeum vulgare) [TaxId:4513] [51483] (1 PDB entry)
    2. 571247Species Soybean (Glycine max) [TaxId:3847] [51482] (15 PDB entries)
    3. 571269Species Sweet potato (Ipomoea batatas) [TaxId:4120] [51484] (1 PDB entry)
  10. 571271Cyclodextrin glycosyltransferase [51452] (5 species)
    contains two more all-beta domains, one is Immunoglobulin-like and the other is trasthyretin-like
    1. 571272Species Alkalophilic bacillus sp., strain 1011 [51456] (8 PDB entries)
    2. 571289Species Bacillus circulans, different strains [TaxId:1397] [51453] (36 PDB entries)
    3. 571330Species Bacillus stearothermophilus [TaxId:1422] [51454] (1 PDB entry)
    4. 571332Species Bacillus stearothermophilus, maltogenic alpha-amylase [TaxId:1422] [51455] (2 PDB entries)
    5. 571335Species Thermoanaerobacterium thermosulfurigenes, EM1 [TaxId:33950] [51457] (2 PDB entries)
  11. 571338Cyclomaltodextrinase, central domain [102058] (1 species)
    protein shares similar domain organization with maltogenic amylases but differs in the spatial arrangement of its domains
  12. 571342Fungal alpha-amylases [51462] (2 species)
    1. 571343Species Aspergillus niger, acid amylase [TaxId:5061] [51463] (1 PDB entry)
    2. 571345Species Aspergillus oryzae, Taka-amylase [TaxId:5062] [51464] (3 PDB entries)
  13. 571349G4-amylase (1,4-alpha-D-glucan maltotetrahydrolase) [51472] (1 species)
  14. 571360Glycosyltrehalose trehalohydrolase, central domain [51468] (1 species)
    contains an additional N-terminal domain
  15. 571364Isoamylase, central domain [51470] (1 species)
  16. 571367Isomaltulose synthase PalI [89466] (1 species)
  17. 571370Maltogenic amylase, central domain [51465] (4 species)
    contains an additional N-terminal domain
    1. 571371Species Bacillus sp., cyclomaltodextrinase [TaxId:1409] [75060] (1 PDB entry)
    2. 571374Species Thermoactinomyces vulgaris, TVAI [TaxId:2026] [75061] (6 PDB entries)
    3. 571382Species Thermoactinomyces vulgaris, TVAII [TaxId:2026] [51467] (7 PDB entries)
    4. 571397Species Thermus sp. [TaxId:275] [51466] (2 PDB entries)
  18. 571402Maltooligosyl trehalose synthase [82242] (1 species)
    elaborated with several large insertions in the common fold
  19. 571405Maltosyltransferase [63904] (1 species)
    similar to bacterial alpha-amylase; contains larger insertion domain
  20. 571409Melibiase [75064] (4 species)
    1. 571410Species Chicken (Gallus gallus) [TaxId:9031] [75065] (2 PDB entries)
      alpha-N-acetylgalactosaminidase
    2. 571413Species Human (Homo sapiens) [TaxId:9606] [102062] (2 PDB entries)
      alpha-galactosidase A
    3. 571418Species Rice (Oryza sativa) [TaxId:4530] [89468] (1 PDB entry)
      alpha-galactosidase
    4. 571420Species Trichoderma reesei [TaxId:51453] [110349] (2 PDB entries)
      Alpha-galactosidase agl1
  21. 571423Neopullulanase, central domain [82240] (1 species)
    homologous to Maltogenic amylase
  22. 571433Oligo-1,6, glucosidase [51476] (1 species)
  23. 571436Plant alpha-amylase [51474] (2 species)
    1. 571437Species Barley (Hordeum vulgare), AMY1 isozyme [TaxId:4513] [89465] (2 PDB entries)
    2. 571440Species Barley (Hordeum vulgare), seeds, AMY2 isozyme [TaxId:4513] [51475] (3 PDB entries)
  24. 571445Sucrose phosphorylase [102060] (1 species)
    sequence and close structural relationship to amylosucrase; variations in the C-terminal domain fold

More info for Family c.1.8.1: Amylase, catalytic domain

Timeline for Family c.1.8.1: Amylase, catalytic domain: