Lineage for Family c.1.8.1: Amylase, catalytic domain

  1. Root: SCOP 1.69
  2. 473232Class c: Alpha and beta proteins (a/b) [51349] (136 folds)
  3. 473233Fold c.1: TIM beta/alpha-barrel [51350] (31 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 474052Superfamily c.1.8: (Trans)glycosidases [51445] (11 families) (S)
  5. 474053Family c.1.8.1: Amylase, catalytic domain [51446] (24 proteins)
    members of the family may contain various insert subdomains
    in alpha-amylases and closer relatives this domain is usually followed by a common all-beta domain

Proteins:

  1. 4740541,4-alpha-glucan branching enzyme, central domain [82244] (1 species)
  2. 4740604-alpha-glucanotransferase [75062] (1 species)
  3. 474066A4 beta-galactosidase [82246] (1 species)
    the catalytic domain is very similar to that of the bacterial beta-amylase; but contains a typical alpha-amylase extra domain
  4. 474070Amylomaltase MalQ [51478] (1 species)
    4-alpha-glucanotransferase; single-domain amylase with several insertions in the common fold
  5. 474076Amylosucrase [69384] (1 species)
  6. 474087Animal alpha-amylase [51458] (3 species)
    contains Ca2+-binding subdomain, residues 100-170
    1. 474088Species Human (Homo sapiens) [TaxId:9606] [51460] (23 PDB entries)
    2. 474112Species Pig (Sus scrofa) [TaxId:9823] [51459] (12 PDB entries)
    3. 474131Species Yellow mealworm (Tenebrio molitor), larva [TaxId:7067] [51461] (4 PDB entries)
  7. 474136Bacterial alpha-amylase [51447] (7 species)
    1. 474137Species Archaeon Pyrococcus woesei [TaxId:2262] [89464] (3 PDB entries)
    2. 474141Species Bacillus licheniformis [TaxId:1402] [51448] (4 PDB entries)
    3. 474146Species Bacillus sp., ksm-k38 [TaxId:1409] [89463] (6 PDB entries)
    4. 474153Species Bacillus stearothermophilus [TaxId:1422] [51451] (1 PDB entry)
    5. 474155Species Bacillus subtilis [TaxId:1423] [51450] (2 PDB entries)
    6. 474158Species Chimera (Bacillus amyloliquefaciens) and (Bacillus licheniformis) [TaxId:1390] [63903] (4 PDB entries)
      the N-terminal 300 residues are from B. amyloliquefaciens
    7. 474163Species Pseudoalteromonas haloplanctis (Alteromonas haloplanctis) [51449] (9 PDB entries)
  8. 474173Bacterial beta-amylase [51485] (1 species)
    protein contains additional starch-binding domain
  9. 474203beta-Amylase [51481] (3 species)
    Common fold covers whole protein structure
    1. 474204Species Barley (Hordeum vulgare) [TaxId:4513] [51483] (1 PDB entry)
    2. 474206Species Soybean (Glycine max) [TaxId:3847] [51482] (15 PDB entries)
    3. 474228Species Sweet potato (Ipomoea batatas) [TaxId:4120] [51484] (1 PDB entry)
  10. 474230Cyclodextrin glycosyltransferase [51452] (5 species)
    contains two more all-beta domains, one is Immunoglobulin-like and the other is trasthyretin-like
    1. 474231Species Alkalophilic bacillus sp., strain 1011 [51456] (8 PDB entries)
    2. 474248Species Bacillus circulans, different strains [TaxId:1397] [51453] (36 PDB entries)
    3. 474289Species Bacillus stearothermophilus [TaxId:1422] [51454] (1 PDB entry)
    4. 474291Species Bacillus stearothermophilus, maltogenic alpha-amylase [TaxId:1422] [51455] (2 PDB entries)
    5. 474294Species Thermoanaerobacterium thermosulfurigenes, EM1 [TaxId:33950] [51457] (2 PDB entries)
  11. 474297Cyclomaltodextrinase, central domain [102058] (1 species)
    protein shares similar domain organization with maltogenic amylases but differs in the spatial arrangement of its domains
  12. 474301Fungal alpha-amylases [51462] (2 species)
    1. 474302Species Aspergillus niger, acid amylase [TaxId:5061] [51463] (1 PDB entry)
    2. 474304Species Aspergillus oryzae, Taka-amylase [TaxId:5062] [51464] (3 PDB entries)
  13. 474308G4-amylase (1,4-alpha-D-glucan maltotetrahydrolase) [51472] (1 species)
  14. 474319Glycosyltrehalose trehalohydrolase, central domain [51468] (1 species)
    contains an additional N-terminal domain
  15. 474323Isoamylase, central domain [51470] (1 species)
  16. 474326Isomaltulose synthase PalI [89466] (1 species)
  17. 474329Maltogenic amylase, central domain [51465] (4 species)
    contains an additional N-terminal domain
    1. 474330Species Bacillus sp., cyclomaltodextrinase [TaxId:1409] [75060] (1 PDB entry)
    2. 474333Species Thermoactinomyces vulgaris, TVAI [TaxId:2026] [75061] (6 PDB entries)
    3. 474341Species Thermoactinomyces vulgaris, TVAII [TaxId:2026] [51467] (7 PDB entries)
    4. 474356Species Thermus sp. [TaxId:275] [51466] (2 PDB entries)
  18. 474361Maltooligosyl trehalose synthase [82242] (1 species)
    elaborated with several large insertions in the common fold
  19. 474364Maltosyltransferase [63904] (1 species)
    similar to bacterial alpha-amylase; contains larger insertion domain
  20. 474368Melibiase [75064] (4 species)
    1. 474369Species Chicken (Gallus gallus) [TaxId:9031] [75065] (2 PDB entries)
      alpha-N-acetylgalactosaminidase
    2. 474372Species Human (Homo sapiens) [TaxId:9606] [102062] (2 PDB entries)
      alpha-galactosidase A
    3. 474377Species Rice (Oryza sativa) [TaxId:4530] [89468] (1 PDB entry)
      alpha-galactosidase
    4. 474379Species Trichoderma reesei [TaxId:51453] [110349] (1 PDB entry)
      Alpha-galactosidase agl1
  21. 474381Neopullulanase, central domain [82240] (1 species)
    homologous to Maltogenic amylase
  22. 474391Oligo-1,6, glucosidase [51476] (1 species)
  23. 474394Plant alpha-amylase [51474] (2 species)
    1. 474395Species Barley (Hordeum vulgare), AMY1 isozyme [TaxId:4513] [89465] (2 PDB entries)
    2. 474398Species Barley (Hordeum vulgare), seeds, AMY2 isozyme [TaxId:4513] [51475] (3 PDB entries)
  24. 474403Sucrose phosphorylase [102060] (1 species)
    sequence and close structural relationship to amylosucrase; variations in the C-terminal domain fold

More info for Family c.1.8.1: Amylase, catalytic domain

Timeline for Family c.1.8.1: Amylase, catalytic domain: