Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies) contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678 the first seven superfamilies have similar phosphate-binding sites |
Superfamily c.1.8: (Trans)glycosidases [51445] (15 families) |
c.1.8.1: Amylase, catalytic domain [51446] (26 proteins) members of the family may contain various insert subdomains in alpha-amylases and closer relatives this domain is usually followed by a common all-beta domain |
c.1.8.3: beta-glycanases [51487] (27 proteins) consist of a number of sequence families |
c.1.8.4: Family 1 of glycosyl hydrolase [51521] (6 proteins) |
c.1.8.5: Type II chitinase [51534] (15 proteins) glycosylase family 18 |
c.1.8.6: beta-N-acetylhexosaminidase catalytic domain [51550] (5 proteins) Glycosyl hydrolase family 20, GH20 |
c.1.8.7: NagZ-like [51553] (3 proteins) Pfam PF00933; Glycosyl hydrolase family 3 domain |
c.1.8.8: 1,4-beta-N-acetylmuraminidase [63912] (3 proteins) Glycosyl hydrolase family 25; probably have evolved from a type II chitinase ancestor permutation of the common fold; strand 8 is antiparallel to the rest of the barrel |
c.1.8.9: Bee venom hyaluronidase [69387] (2 proteins) distorted barrel lacks the second strand |
c.1.8.10: alpha-D-glucuronidase/Hyaluronidase catalytic domain [82253] (3 proteins) Glycosyl hydrolase family 67, GH67; structurally related to GH20; contains extra C-terminal alpha-helical subdomain |
c.1.8.11: Putative alpha-L-fucosidase, catalytic domain [102079] (1 protein) glycosyl hydrolase family 29; contains additional beta-barrel with a topological similarity to the C-terminal domain of alpha amylases |
c.1.8.12: Outer surface protein, N-terminal domain [110354] (1 protein) corresponds to the N-terminal part of Pfam PF05913 |
c.1.8.13: YicI catalytic domain-like [117372] (2 proteins) |
c.1.8.14: Glycosyl hydrolases family 35 catalytic domain [117375] (1 protein) Pfam PF01301 |
c.1.8.15: TM1410-like [141796] (1 protein) Pfam PF03537 |
c.1.8.0: automated matches [191314] (1 protein) not a true family |
Timeline for Superfamily c.1.8: (Trans)glycosidases: