Lineage for Protein: 3-alpha-hydroxysteroid dehydrogenase

  1. Root: SCOPe 2.07
  2. 2434694Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2434695Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2437818Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families) (S)
  5. 2437819Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
    Common fold covers whole protein structure
  6. 2437839Protein 3-alpha-hydroxysteroid dehydrogenase [51439] (2 species)

Species:

  1. 2437840Human (Homo sapiens), type III [TaxId:9606] [69383] (16 PDB entries)
    bile acid binding protein
    1. Domains for 1ihi:
      1. 2437871Domain d1ihia_: 1ihi A: [66142]
        complexed with iu5, nap
      2. 2437872Domain d1ihib_: 1ihi B: [66143]
        complexed with iu5, nap
    2. Domains for 1j96:
      1. 2437841Domain d1j96a1: 1j96 A:2-323 [71616]
        Other proteins in same PDB: d1j96a2, d1j96b2
        complexed with act, nap, tes
      2. 2437842Domain d1j96b1: 1j96 B:2-323 [71617]
        Other proteins in same PDB: d1j96a2, d1j96b2
        complexed with act, nap, tes
    3. Domains for 1xjb:
      1. 2437855Domain d1xjba2: 1xjb A:2-323 [122032]
        Other proteins in same PDB: d1xjba3
        automated match to d1j96a_
        complexed with act, bme, cit, edo, nap, so4
      2. 2437856Domain d1xjbb_: 1xjb B: [122033]
        Other proteins in same PDB: d1xjba3
        automated match to d1j96a_
        complexed with act, bme, cit, edo, nap, so4
    4. Domains for 2hdj:
      1. 2437863Domain d2hdja_: 2hdj A: [136343]
        automated match to d1j96a_
        complexed with edo, ndp, so4
      2. 2437864Domain d2hdjb_: 2hdj B: [136344]
        automated match to d1j96a_
        complexed with edo, ndp, so4
    5. Domains for 2ipj:
      1. 2437853Domain d2ipja_: 2ipj A: [165634]
        automated match to d1j96a_
        complexed with bme, edo, ffa, nap, so4; mutant
      2. 2437854Domain d2ipjb_: 2ipj B: [165635]
        automated match to d1j96a_
        complexed with bme, edo, ffa, nap, so4; mutant
    6. Domains for 4jq1:
      1. 2437857Domain d4jq1a_: 4jq1 A: [252997]
        automated match to d4jqab_
        complexed with edo, nap, nps, po4, tla
      2. 2437858Domain d4jq1b_: 4jq1 B: [252998]
        automated match to d4jqab_
        complexed with edo, nap, nps, po4, tla
    7. Domains for 4jq2:
      1. 2437859Domain d4jq2a_: 4jq2 A: [252999]
        automated match to d4jqab_
        complexed with edo, nap, po4, suz, tla
      2. 2437860Domain d4jq2b_: 4jq2 B: [253000]
        automated match to d4jqab_
        complexed with edo, nap, po4, suz, tla
    8. Domains for 4jq3:
      1. 2437861Domain d4jq3a_: 4jq3 A: [253001]
        automated match to d4jqab_
        complexed with edo, nap, po4, tla, zom
      2. 2437862Domain d4jq3b_: 4jq3 B: [253002]
        automated match to d4jqab_
        complexed with edo, nap, po4, tla, zom
    9. Domains for 4jq4:
      1. 2437851Domain d4jq4a_: 4jq4 A: [253003]
        automated match to d4jqab_
        complexed with edo, imn, nap, po4, tla
      2. 2437852Domain d4jq4b_: 4jq4 B: [253004]
        automated match to d4jqab_
        complexed with edo, imn, nap, po4, tla
    10. Domains for 4jqa:
      1. 2437847Domain d4jqaa_: 4jqa A: [240348]
        automated match to d4jqab_
        complexed with edo, id8, na, nap, po4, tla
      2. 2437848Domain d4jqab_: 4jqa B: [238145]
        automated match to d2fgba_
        complexed with edo, id8, na, nap, po4, tla
    11. Domains for 4jtq:
      1. 2437849Domain d4jtqa_: 4jtq A: [253030]
        automated match to d4jqab_
        complexed with edo, flp, nap, po4, tla
      2. 2437850Domain d4jtqb_: 4jtq B: [253031]
        automated match to d4jqab_
        complexed with edo, flp, nap, po4, tla
    12. Domains for 4jtr:
      1. 2437843Domain d4jtra_: 4jtr A: [253032]
        automated match to d4jqab_
        complexed with edo, ibp, izp, nap, po4, tla
      2. 2437844Domain d4jtrb_: 4jtr B: [253033]
        automated match to d4jqab_
        complexed with edo, ibp, izp, nap, po4, tla
    13. Domains for 4l1w:
      1. 2437869Domain d4l1wa1: 4l1w A:2-323 [256963]
        Other proteins in same PDB: d4l1wa2, d4l1wb2
        automated match to d1xjba_
        complexed with nap, so4, str
      2. 2437870Domain d4l1wb1: 4l1w B:2-323 [256964]
        Other proteins in same PDB: d4l1wa2, d4l1wb2
        automated match to d1xjba_
        complexed with nap, so4, str
    14. Domains for 4l1x:
      1. 2437865Domain d4l1xa1: 4l1x A:2-323 [256965]
        Other proteins in same PDB: d4l1xa2, d4l1xb2
        automated match to d1xjba_
        complexed with nap, so4, str; mutant
      2. 2437866Domain d4l1xb1: 4l1x B:2-323 [262898]
        Other proteins in same PDB: d4l1xa2, d4l1xb2
        automated match to d1xjba_
        complexed with nap, so4, str; mutant
    15. Domains for 4xo6:
      1. 2437845Domain d4xo6a1: 4xo6 A:2-323 [316445]
        Other proteins in same PDB: d4xo6a2, d4xo6b2
        automated match to d2fgba_
        complexed with 5sd, aox, edo, gol, nap, so4
      2. 2437846Domain d4xo6b1: 4xo6 B:2-323 [316496]
        Other proteins in same PDB: d4xo6a2, d4xo6b2
        automated match to d2fgba_
        complexed with 5sd, aox, edo, gol, nap, so4
    16. Domains for 4xo7:
      1. 2437867Domain d4xo7a_: 4xo7 A: [311882]
        automated match to d1ihia_
        complexed with asd, nap, so4
      2. 2437868Domain d4xo7b_: 4xo7 B: [311829]
        automated match to d1ihia_
        complexed with asd, nap, so4
  2. 2437873Norway rat (Rattus norvegicus) [TaxId:10116] [51440] (3 PDB entries)
    1. Domains for 1afs:
      1. 2437874Domain d1afsa_: 1afs A: [28694]
        complexed with nap, tes
      2. 2437875Domain d1afsb_: 1afs B: [28695]
        complexed with nap, tes
    2. Domains for 1lwi:
      1. 2437876Domain d1lwia_: 1lwi A: [28696]
        complexed with nap
      2. 2437877Domain d1lwib_: 1lwi B: [28697]
        complexed with nap
    3. Domain for 1ral:

More info for Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP)

Timeline for Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP):