SCOP 1.63: Family c.1.7.1: Aldo-keto reductases (NADP)

Lineage for Family c.1.7.1: Aldo-keto reductases (NADP)

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (26 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (1 family)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (8 proteins)
   Common fold covers whole protein structure

Proteins:

1. 2,5-diketo-D-gluconic acid reductase A [51443] (1 species)

   • Species Corynebacterium sp. [TaxId:1720] [51444] (2 PDB entries)

2. 3-alpha-hydroxysteroid dehydrogenase [51439] (2 species)

   1. Species Human (Homo sapiens), type III [TaxId:9606] [69383] (2 PDB entries)
      bile acid binding protein

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [51440] (3 PDB entries)

3. Aflatoxin aldehyde reductase (akr7a1) [75056] (1 species)

   • Species Rat (Rattus norvegicus) [TaxId:10116] [75057] (1 PDB entry)

4. Aldose reductase (aldehyde reductase) [51436] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [51437] (13 PDB entries)

   2. Species Pig (Sus scrofa) [TaxId:9823] [51438] (8 PDB entries)

5. CHO reductase [51441] (1 species)

   • Species Chinese hampster (Cricetulus griseus) [51442] (1 PDB entry)

6. FR-1 (fibroblast growth factor-induced) protein [51432] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [51433] (1 PDB entry)

7. Voltage-dependent K+ channel beta subunit [51434] (1 species)

   • Species Rat (Rattus norvegicus) [TaxId:10116] [51435] (2 PDB entries)

8. Xylose reductase [75058] (1 species)

   • Species Fungi (Candida tenuis) [TaxId:45596] [75059] (2 PDB entries)

More info for Family c.1.7.1: Aldo-keto reductases (NADP)

Timeline for Family c.1.7.1: Aldo-keto reductases (NADP):

• Family c.1.7.1: Aldo-keto reductases (NADP) first appeared (with stable ids) in SCOP 1.55
  
• Family c.1.7.1: Aldo-keto reductases (NADP) appears in SCOP 1.61
  
• Family c.1.7.1: Aldo-keto reductases (NADP) appears in SCOP 1.65
  
• Family c.1.7.1: Aldo-keto reductases (NADP) appears in the current release, SCOPe 2.08