SCOP 1.73: Protein: Inosine monophosphate dehydrogenase (IMPDH)

Lineage for Protein: Inosine monophosphate dehydrogenase (IMPDH)

Root: SCOP 1.73
Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites

Superfamily c.1.5: Inosine monophosphate dehydrogenase (IMPDH) [51412] (1 family)
The phosphate moiety of substrate binds in the 'common' phosphate-binding site
Family c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) [51413] (1 protein)
Protein Inosine monophosphate dehydrogenase (IMPDH) [51414] (6 species)

Species:

Chinese hamster (Cricetulus griseus) [TaxId:10029] [63902] (1 PDB entry)
- Domains for 1jr1:
  1. Domain d1jr1a1: 1jr1 A:17-112,A:233-514 [63241]
    Other proteins in same PDB: d1jr1a2, d1jr1a3
  2. Domain d1jr1b1: 1jr1 B:11-112,B:233-514 [63244]
    Other proteins in same PDB: d1jr1a2, d1jr1a3
    contains two CBS domains inserted into the common fold, residues 113-232
    complexed with imp, k, moa

Human (Homo sapiens), type I [TaxId:9606] [89456] (1 PDB entry)

Domains for 1jcn:

Domain d1jcna1: 1jcn A:10-111,A:232-499 [84160]
Other proteins in same PDB: d1jcna2, d1jcna3, d1jcnb2, d1jcnb3

Domain d1jcnb1: 1jcn B:10-111,B:232-499 [84163]
Other proteins in same PDB: d1jcna2, d1jcna3, d1jcnb2, d1jcnb3
contains two CBS domains inserted into the common fold, residues 111-231
complexed with cpr

Human (Homo sapiens), type II [TaxId:9606] [51418] (3 PDB entries)
1. Domains for 1b3o:
  1. Domain d1b3oa1: 1b3o A:10-109,A:232-499 [28640]
    Other proteins in same PDB: d1b3ob2, d1b3ob3
  2. Domain d1b3ob1: 1b3o B:10-111,B:232-499 [28641]
    Other proteins in same PDB: d1b3ob2, d1b3ob3
    contains two CBS domains inserted into the common fold, residues 112-231
    complexed with cpr, sae
2. Domains for 1nf7:
  1. Domain d1nf7a1: 1nf7 A:10-111,A:232-514 [91852]
    Other proteins in same PDB: d1nf7a2, d1nf7a3, d1nf7b2, d1nf7b3
  2. Domain d1nf7b1: 1nf7 B:10-111,B:232-514 [91855]
    Other proteins in same PDB: d1nf7a2, d1nf7a3, d1nf7b2, d1nf7b3
    complexed with k, myd, rvp
3. Domains for 1nfb:
  1. Domain d1nfba1: 1nfb A:10-111,A:232-498 [91858]
    Other proteins in same PDB: d1nfba2, d1nfba3, d1nfbb2, d1nfbb3
  2. Domain d1nfbb1: 1nfb B:10-111,B:232-498 [91861]
    Other proteins in same PDB: d1nfba2, d1nfba3, d1nfbb2, d1nfbb3
    complexed with cpr, nad
Lyme disease spirochete (Borrelia burgdorferi) [TaxId:139] [51415] (1 PDB entry)
- Domains for 1eep:
  1. Domain d1eepa_: 1eep A: [28636]
  2. Domain d1eepb_: 1eep B: [28637]
    complexed with so4
Streptococcus pyogenes [TaxId:1314] [51416] (1 PDB entry)
- Domain for 1zfj:
  - Domain d1zfja1: 1zfj A:2-94,A:221-492 [28638]
    Other proteins in same PDB: d1zfja2, d1zfja3
    contains two CBS domains inserted into the common fold
    complexed with imp
Tritrichomonas foetus [TaxId:5724] [51417] (9 PDB entries)
1. Domain for 1ak5:
  - Domain d1ak5a1: 1ak5 A:2-101,A:222-483 [28639]
    there two CBS domains in the disordered region 102-221
    complexed with so4
2. Domains for 1lrt:
  1. Domain d1lrta1: 1lrt A:2-100,A:231-485 [84685]
  2. Domain d1lrtb1: 1lrt B:2-100,B:231-485 [84686]
  3. Domain d1lrtc1: 1lrt C:2-100,C:231-485 [84687]
  4. Domain d1lrtd1: 1lrt D:2-100,D:231-485 [84688]
    there are two CBS domains in the disordered region 101-230
    complexed with bog, imp, k, tad, trs
3. Domain for 1me7:
  - Domain d1me7a1: 1me7 A:2-107,A:220-492 [79027]
    there two CBS domains in the disordered region 108-219
    complexed with k, moa, na, rvp
4. Domain for 1me8:
  - Domain d1me8a1: 1me8 A:2-101,A:222-492 [79028]
    there two CBS domains in the disordered region 102-221
    complexed with cso, k, na, rvp
5. Domain for 1me9:
  - Domain d1me9a1: 1me9 A:2-101,A:222-483 [91249]
    there two CBS domains in the disordered region 102-221
    complexed with imp, k
6. Domain for 1meh:
  - Domain d1meha1: 1meh A:2-106,A:222-483 [91250]
    there two CBS domains in the disordered region 107-221
    complexed with imp, k, moa
7. Domain for 1mei:
  - Domain d1meia1: 1mei A:2-101,A:222-483 [91251]
    there two CBS domains in the disordered region 102-221
    complexed with k, moa, xmp
8. Domain for 1mew:
  - Domain d1mewa1: 1mew A:2-101,A:222-483 [91256]
    there two CBS domains in the disordered region 102-221
    complexed with k, nad, xmp
9. Domains for 1pvn:
  1. Domain d1pvna1: 1pvn A:2-99,A:231-494 [88312]
  2. Domain d1pvnb1: 1pvn B:2-99,B:231-494 [88313]
  3. Domain d1pvnc1: 1pvn C:2-99,C:231-494 [88314]
  4. Domain d1pvnd1: 1pvn D:2-99,D:231-494 [88315]
    there are two CBS domains in the disordered region 100-230
    complexed with k, mzp, trs

More info for Protein Inosine monophosphate dehydrogenase (IMPDH) from c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH)

Timeline for Protein Inosine monophosphate dehydrogenase (IMPDH) from c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH):

Protein Inosine monophosphate dehydrogenase (IMPDH) from c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) first appeared (with stable ids) in SCOP 1.55
Protein Inosine monophosphate dehydrogenase (IMPDH) from c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) appears in SCOP 1.71
Protein Inosine monophosphate dehydrogenase (IMPDH) from c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) appears in SCOP 1.75
Protein Inosine monophosphate dehydrogenase (IMPDH) from c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) appears in the current release, SCOPe 2.08