Lineage for Protein: Inosine monophosphate dehydrogenase (IMPDH)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2080656Superfamily c.1.5: Inosine monophosphate dehydrogenase (IMPDH) [51412] (2 families) (S)
    The phosphate moiety of substrate binds in the 'common' phosphate-binding site
  5. 2080657Family c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) [51413] (1 protein)
  6. 2080658Protein Inosine monophosphate dehydrogenase (IMPDH) [51414] (8 species)

Species:

  1. 2080659Chinese hamster (Cricetulus griseus) [TaxId:10029] [63902] (1 PDB entry)
  2. 2080662Human (Homo sapiens), type I [TaxId:9606] [89456] (1 PDB entry)
  3. 2080665Human (Homo sapiens), type II [TaxId:9606] [51418] (3 PDB entries)
    1. Domains for 1b3o:
      1. 2080666Domain d1b3oa1: 1b3o A:10-109,A:232-499 [28640]
        Other proteins in same PDB: d1b3ob4
        contains two CBS domains inserted into the common fold, residues 112-231
        complexed with cpr, sae, unx
      2. 2080667Domain d1b3ob1: 1b3o B:10-111,B:232-499 [28641]
        Other proteins in same PDB: d1b3ob4
        contains two CBS domains inserted into the common fold, residues 112-231
        complexed with cpr, sae, unx
    2. Domains for 1nf7:
      1. 2080668Domain d1nf7a1: 1nf7 A:10-111,A:232-514 [91852]
        Other proteins in same PDB: d1nf7a4, d1nf7b4
        complexed with k, myd, rvp, unk
      2. 2080669Domain d1nf7b1: 1nf7 B:10-111,B:232-514 [91855]
        Other proteins in same PDB: d1nf7a4, d1nf7b4
        complexed with k, myd, rvp, unk
    3. Domains for 1nfb:
      1. 2080670Domain d1nfba1: 1nfb A:10-111,A:232-498 [91858]
        Other proteins in same PDB: d1nfba4, d1nfbb4
        complexed with cpr, nad
      2. 2080671Domain d1nfbb1: 1nfb B:10-111,B:232-498 [91861]
        Other proteins in same PDB: d1nfba4, d1nfbb4
        complexed with cpr, nad
  4. 2080672Lyme disease spirochete (Borrelia burgdorferi) [TaxId:139] [51415] (1 PDB entry)
  5. 2080675Pyrococcus horikoshii [TaxId:53953] [159379] (1 PDB entry)
    Uniprot O58045 3-96,207-480
  6. 2080678Streptococcus pyogenes [TaxId:1314] [51416] (1 PDB entry)
  7. 2080680Thermotoga maritima [TaxId:2336] [159378] (1 PDB entry)
    Uniprot Q9X168 1-85,213-457
  8. 2080683Tritrichomonas foetus [TaxId:5724] [51417] (10 PDB entries)
    1. Domain for 1ak5:
    2. Domains for 1lrt:
      1. 2080697Domain d1lrta1: 1lrt A:2-100,A:231-485 [84685]
        there are two CBS domains in the disordered region 101-230
        complexed with bog, imp, k, tad, trs
      2. 2080698Domain d1lrtb1: 1lrt B:2-100,B:231-485 [84686]
        there are two CBS domains in the disordered region 101-230
        complexed with bog, imp, k, tad, trs
      3. 2080699Domain d1lrtc1: 1lrt C:2-100,C:231-485 [84687]
        there are two CBS domains in the disordered region 101-230
        complexed with bog, imp, k, tad, trs
      4. 2080700Domain d1lrtd1: 1lrt D:2-100,D:231-485 [84688]
        there are two CBS domains in the disordered region 101-230
        complexed with bog, imp, k, tad, trs
    3. Domain for 1me7:
    4. Domain for 1me8:
    5. Domain for 1me9:
    6. Domain for 1meh:
    7. Domain for 1mei:
    8. Domain for 1mew:
    9. Domains for 1mwf:
      1. 2080684Domain d1mwfa1: 1mwf A:2-99,A:231-494 [302742]
        automated match to d1lrta1
        complexed with k, mzp, trs
      2. 2080685Domain d1mwfb1: 1mwf B:2-99,B:231-494 [302743]
        automated match to d1lrta1
        complexed with k, mzp, trs
      3. 2080686Domain d1mwfc1: 1mwf C:2-99,C:231-494 [302744]
        automated match to d1lrta1
        complexed with k, mzp, trs
      4. 2080687Domain d1mwfd1: 1mwf D:2-99,D:231-494 [302745]
        automated match to d1lrta1
        complexed with k, mzp, trs
    10. Domains for 1pvn:
      1. 2080688Domain d1pvna1: 1pvn A:2-99,A:231-494 [88312]
        there are two CBS domains in the disordered region 100-230
        complexed with k, mzp, trs
      2. 2080689Domain d1pvnb1: 1pvn B:2-99,B:231-494 [88313]
        there are two CBS domains in the disordered region 100-230
        complexed with k, mzp, trs
      3. 2080690Domain d1pvnc1: 1pvn C:2-99,C:231-494 [88314]
        there are two CBS domains in the disordered region 100-230
        complexed with k, mzp, trs
      4. 2080691Domain d1pvnd1: 1pvn D:2-99,D:231-494 [88315]
        there are two CBS domains in the disordered region 100-230
        complexed with k, mzp, trs

More info for Protein Inosine monophosphate dehydrogenase (IMPDH) from c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH)

Timeline for Protein Inosine monophosphate dehydrogenase (IMPDH) from c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH):