SCOP 1.71: Family c.1.4.1: FMN-linked oxidoreductases

Lineage for Family c.1.4.1: FMN-linked oxidoreductases

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (32 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (1 family)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (15 proteins)

Proteins:

1. 12-oxophytodienoate reductase (OPR, OYE homolog) [63896] (3 species)

   1. Species Thale cress (Arabidopsis thaliana), OPR1 [TaxId:3702] [102040] (1 PDB entry)
      At1G76680

   2. Species Thale cress (Arabidopsis thaliana), OPR3 [TaxId:3702] [102041] (1 PDB entry)

   3. Species Tomato (Lycopersicon esculentum), OPR1 [TaxId:4081] [63897] (3 PDB entries)

2. 2,4-dienoyl-CoA reductase, N-terminal domain [102042] (1 species)

   • Species Escherichia coli [TaxId:562] [102043] (1 PDB entry)

3. Alpha subunit of glutamate synthase, central and FMN domains [69381] (2 species)
   Central domain (residues 423-780) may be a rudiment form of the FMN domain

   1. Species Azospirillum brasilense [TaxId:192] [69382] (1 PDB entry)

   2. Species Synechocystis sp. [TaxId:1143] [75055] (5 PDB entries)

4. Dihydroorotate dehydrogenase [51397] (5 species)

   1. Species Escherichia coli [TaxId:562] [82239] (1 PDB entry)

   2. Species Human (Homo sapiens) [TaxId:9606] [51400] (2 PDB entries)

   3. Species Lactococcus lactis, isozyme A [TaxId:1358] [51398] (9 PDB entries)

   4. Species Lactococcus lactis, isozyme B [TaxId:1358] [51399] (3 PDB entries)
      PyrD subunit

   5. Species Rat (Rattus norvegicus) [TaxId:10116] [102039] (2 PDB entries)

5. Dihydropyrimidine dehydrogenase, domain 4 [51410] (1 species)

   • Species Pig (Sus scrofa) [TaxId:9823] [51411] (5 PDB entries)

6. Flavocytochrome b2, C-terminal domain [51408] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51409] (10 PDB entries)
     N-terminal domain homologous to cytochrome b5

7. Glycolate oxidase [51404] (1 species)

   • Species Spinach (Spinacia oleracea) [TaxId:3562] [51405] (4 PDB entries)

8. Isopentenyl-diphosphate delta-isomerase [89454] (1 species)

   • Species Bacillus subtilis [TaxId:1423] [89455] (2 PDB entries)

9. Membrane-associated (S)-mandelate dehydrogenase [63898] (1 species)

   • Species Pseudomonas putida [TaxId:303] [63899] (3 PDB entries)

10. Morphinone reductase [75053] (1 species)

    • Species Pseudomonas putida [TaxId:303] [75054] (1 PDB entry)

11. Old yellow enzyme (OYE) [51401] (2 species)

    1. Species Brewer's yeast (Saccharomyces carlsbergensis) [51402] (5 PDB entries)

    2. Species Yeast (Candida albicans) [TaxId:5476] [51403] (2 PDB entries)

12. PcrB protein homolog YerE [102046] (1 species)
    provisional classification; it is not known whether this protein binds FMN or not

    • Species Bacillus subtilis [TaxId:1423] [102047] (1 PDB entry)

13. Pentaerythritol tetranirate reductase [63900] (1 species)

    • Species Enterobacter cloacae [TaxId:550] [63901] (13 PDB entries)

14. Putative flavin oxidoreducatase TM0096 [102044] (1 species)
    Dihydrouridine synthase (Dus) homologue; contains extra C-terminal alpha-helical domain

    • Species Thermotoga maritima [TaxId:243274] [102045] (1 PDB entry)

15. Trimethylamine dehydrogenase, N-terminal domain [51406] (1 species)
    two other domains are alpha/beta Rossmann-like fold and beta/beta/alpha fold

    • Species Methylophilus methylotrophus, w3a1 [TaxId:17] [51407] (5 PDB entries)

More info for Family c.1.4.1: FMN-linked oxidoreductases

Timeline for Family c.1.4.1: FMN-linked oxidoreductases:

• Family c.1.4.1: FMN-linked oxidoreductases first appeared (with stable ids) in SCOP 1.55
  
• Family c.1.4.1: FMN-linked oxidoreductases appears in SCOP 1.69
  
• Family c.1.4.1: FMN-linked oxidoreductases appears in SCOP 1.73
  
• Family c.1.4.1: FMN-linked oxidoreductases appears in the current release, SCOPe 2.08