SCOP 1.75: Family c.1.2.1: Histidine biosynthesis enzymes

Lineage for Family c.1.2.1: Histidine biosynthesis enzymes

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.2: Ribulose-phoshate binding barrel [51366] (6 families)

5. Family c.1.2.1: Histidine biosynthesis enzymes [51367] (2 proteins)
   structural evidence for the gene duplication within the barrel fold

Proteins:

1. Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF [51370] (4 species)

   1. Species Archaeon Pyrobaculum aerophilum [TaxId:13773] [69380] (1 PDB entry)

   2. Species Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId:4932] [69379] (4 PDB entries)

   3. Species Thermotoga maritima [TaxId:2336] [51371] (4 PDB entries)

   4. Species Thermus thermophilus [TaxId:274] [82237] (1 PDB entry)

2. Phosphoribosylformimino-5-aminoimidazole carboxamide ribotite isomerase HisA [51368] (2 species)

   1. Species Streptomyces coelicolor [TaxId:1902] [141744] (2 PDB entries)
      Uniprot P16250 2-240

   2. Species Thermotoga maritima [TaxId:2336] [51369] (1 PDB entry)

More info for Family c.1.2.1: Histidine biosynthesis enzymes

Timeline for Family c.1.2.1: Histidine biosynthesis enzymes:

• Family c.1.2.1: Histidine biosynthesis enzymes first appeared (with stable ids) in SCOP 1.55
  
• Family c.1.2.1: Histidine biosynthesis enzymes appears in SCOP 1.73
  
• Family c.1.2.1: Histidine biosynthesis enzymes appears in SCOPe 2.01
  
• Family c.1.2.1: Histidine biosynthesis enzymes appears in the current release, SCOPe 2.08