Lineage for Protein: Triosephosphate isomerase

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 814174Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 814175Superfamily c.1.1: Triosephosphate isomerase (TIM) [51351] (1 family) (S)
  5. 814176Family c.1.1.1: Triosephosphate isomerase (TIM) [51352] (1 protein)
  6. 814177Protein Triosephosphate isomerase [51353] (18 species)

Species:

  1. 814178Archaeon Pyrococcus woesei [TaxId:2262] [63891] (1 PDB entry)
  2. 814187Bacillus stearothermophilus [TaxId:1422] [51363] (2 PDB entries)
    1. Domains for 1btm:
      1. 814190Domain d1btma_: 1btm A: [28513]
      2. 814191Domain d1btmb_: 1btm B: [28514]
        complexed with pga
    2. Domains for 2btm:
      1. 814188Domain d2btma_: 2btm A: [28511]
      2. 814189Domain d2btmb_: 2btm B: [28512]
        complexed with pga; mutant
  3. 814192Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51356] (7 PDB entries)
    1. Domains for 1i45:
      1. 814195Domain d1i45a_: 1i45 A: [61665]
      2. 814196Domain d1i45b_: 1i45 B: [61666]
        complexed with ftr; mutant
    2. Domains for 1ney:
      1. 814193Domain d1neya_: 1ney A: [80449]
      2. 814194Domain d1neyb_: 1ney B: [80450]
        complexed with 13p, ftr; mutant
    3. Domains for 1nf0:
      1. 814197Domain d1nf0a_: 1nf0 A: [80451]
      2. 814198Domain d1nf0b_: 1nf0 B: [80452]
        complexed with 13p, ftr; mutant
    4. Domains for 1ypi:
      1. 814201Domain d1ypia_: 1ypi A: [28459]
      2. 814202Domain d1ypib_: 1ypi B: [28460]
    5. Domains for 2ypi:
      1. 814205Domain d2ypia_: 2ypi A: [28461]
      2. 814206Domain d2ypib_: 2ypi B: [28462]
        complexed with pga
    6. Domains for 3ypi:
      1. 814203Domain d3ypia_: 3ypi A: [28463]
      2. 814204Domain d3ypib_: 3ypi B: [28464]
        complexed with pgh; mutant
    7. Domains for 7tim:
      1. 814199Domain d7tima_: 7tim A: [28457]
      2. 814200Domain d7timb_: 7tim B: [28458]
        complexed with pgh
  4. 814207Chicken (Gallus gallus) [TaxId:9031] [51354] (16 PDB entries)
    Uniprot P00940
    1. Domains for 1spq:
      1. 814212Domain d1spqa_: 1spq A: [105878]
      2. 814213Domain d1spqb_: 1spq B: [105879]
        complexed with peg; mutant
    2. Domains for 1sq7:
      1. 814232Domain d1sq7a_: 1sq7 A: [105886]
      2. 814233Domain d1sq7b_: 1sq7 B: [105887]
        mutant
    3. Domains for 1ssd:
      1. 814230Domain d1ssda_: 1ssd A: [105979]
      2. 814231Domain d1ssdb_: 1ssd B: [105980]
        complexed with so4; mutant
    4. Domains for 1ssg:
      1. 814234Domain d1ssga_: 1ssg A: [105984]
      2. 814235Domain d1ssgb_: 1ssg B: [105985]
        complexed with gol, pga, so4; mutant
    5. Domains for 1su5:
      1. 814228Domain d1su5a_: 1su5 A: [106020]
      2. 814229Domain d1su5b_: 1su5 B: [106021]
        complexed with gol, pga, so4; mutant
    6. Domains for 1sw0:
      1. 814210Domain d1sw0a_: 1sw0 A: [106060]
      2. 814211Domain d1sw0b_: 1sw0 B: [106061]
        complexed with pga; mutant
    7. Domains for 1sw3:
      1. 814208Domain d1sw3a_: 1sw3 A: [106065]
      2. 814209Domain d1sw3b_: 1sw3 B: [106066]
        complexed with pga; mutant
    8. Domains for 1sw7:
      1. 814226Domain d1sw7a_: 1sw7 A: [106073]
      2. 814227Domain d1sw7b_: 1sw7 B: [106074]
        complexed with pga; mutant
    9. Domains for 1tim:
      1. 814238Domain d1tima_: 1tim A: [28453]
      2. 814239Domain d1timb_: 1tim B: [28454]
    10. Domains for 1tpb:
      1. 814220Domain d1tpb1_: 1tpb 1: [28445]
      2. 814221Domain d1tpb2_: 1tpb 2: [28446]
        complexed with pgh; mutant
    11. Domains for 1tpc:
      1. 814222Domain d1tpc1_: 1tpc 1: [28447]
      2. 814223Domain d1tpc2_: 1tpc 2: [28448]
        complexed with pgh; mutant
    12. Domains for 1tph:
      1. 814214Domain d1tph1_: 1tph 1: [28439]
      2. 814215Domain d1tph2_: 1tph 2: [28440]
        complexed with pgh
    13. Domains for 1tpu:
      1. 814218Domain d1tpua_: 1tpu A: [28441]
      2. 814219Domain d1tpub_: 1tpu B: [28442]
        complexed with pgh; mutant
    14. Domains for 1tpv:
      1. 814216Domain d1tpva_: 1tpv A: [28443]
      2. 814217Domain d1tpvb_: 1tpv B: [28444]
        complexed with pgh; mutant
    15. Domains for 1tpw:
      1. 814224Domain d1tpwa_: 1tpw A: [28449]
      2. 814225Domain d1tpwb_: 1tpw B: [28450]
        complexed with pgh; mutant
    16. Domains for 8tim:
      1. 814236Domain d8tima_: 8tim A: [28451]
      2. 814237Domain d8timb_: 8tim B: [28452]
        complexed with so4
  5. 814240Entamoeba histolytica [TaxId:5759] [82236] (1 PDB entry)
  6. 814243Escherichia coli [TaxId:562] [51361] (1 PDB entry)
  7. 814246Human (Homo sapiens) [TaxId:9606] [51355] (3 PDB entries)
    1. Domains for 1hti:
      1. 814251Domain d1htia_: 1hti A: [28455]
      2. 814252Domain d1htib_: 1hti B: [28456]
        complexed with pga
    2. Domains for 1wyi:
      1. 814249Domain d1wyia1: 1wyi A:1-248 [121446]
        automatically matched to d1htia_
      2. 814250Domain d1wyib1: 1wyi B:1-248 [121447]
        automatically matched to d1htia_
    3. Domains for 2jk2:
      1. 814247Domain d2jk2a1: 2jk2 A:4-248 [148134]
        automatically matched to d1htia_
      2. 814248Domain d2jk2b1: 2jk2 B:4-248 [148135]
        automatically matched to d1htia_
  8. 814253Leishmania mexicana [TaxId:5665] [51360] (4 PDB entries)
    1. Domain for 1amk:
    2. Domain for 1if2:
    3. Domain for 1n55:
      • 814254Domain d1n55a_: 1n55 A: [80007]
        ultra-high resolution structure
        complexed with acy, gol, pga; mutant
    4. Domain for 1qds:
  9. 814258Nematode (Caenorhabditis elegans) [TaxId:6239] [82235] (1 PDB entry)
  10. 814261Plasmodium falciparum [TaxId:5833] [51359] (9 PDB entries)
    Uniprot Q07412
    1. Domain for 1lyx:
    2. Domains for 1lzo:
      1. 814283Domain d1lzoa_: 1lzo A: [78307]
      2. 814284Domain d1lzob_: 1lzo B: [78308]
      3. 814285Domain d1lzoc_: 1lzo C: [78309]
      4. 814286Domain d1lzod_: 1lzo D: [78310]
        complexed with pga
    3. Domains for 1m7o:
      1. 814271Domain d1m7oa_: 1m7o A: [78740]
      2. 814272Domain d1m7ob_: 1m7o B: [78741]
        complexed with 3pg
    4. Domains for 1m7p:
      1. 814273Domain d1m7pa_: 1m7p A: [78742]
      2. 814274Domain d1m7pb_: 1m7p B: [78743]
        complexed with g3p
    5. Domains for 1o5x:
      1. 814262Domain d1o5xa_: 1o5x A: [92528]
      2. 814263Domain d1o5xb_: 1o5x B: [92529]
        complexed with 2pg, 3py, po3; mutant
    6. Domains for 1vga:
      1. 814264Domain d1vgaa_: 1vga A: [113641]
      2. 814265Domain d1vgab_: 1vga B: [113642]
      3. 814266Domain d1vgac_: 1vga C: [113643]
      4. 814267Domain d1vgad_: 1vga D: [113644]
        mutant
    7. Domains for 1woa:
      1. 814279Domain d1woaa_: 1woa A: [114770]
      2. 814280Domain d1woab_: 1woa B: [114771]
      3. 814281Domain d1woac_: 1woa C: [114772]
      4. 814282Domain d1woad_: 1woa D: [114773]
        complexed with g2h; mutant
    8. Domains for 1wob:
      1. 814275Domain d1woba_: 1wob A: [114774]
      2. 814276Domain d1wobb_: 1wob B: [114775]
      3. 814277Domain d1wobc_: 1wob C: [114776]
      4. 814278Domain d1wobd_: 1wob D: [114777]
        complexed with so4; mutant
    9. Domains for 1ydv:
      1. 814269Domain d1ydva_: 1ydv A: [28501]
      2. 814270Domain d1ydvb_: 1ydv B: [28502]
  11. 814287Rabbit (Oryctolagus cuniculus) [TaxId:9986] [102035] (3 PDB entries)
    1. Domains for 1r2r:
      1. 814288Domain d1r2ra_: 1r2r A: [96875]
      2. 814289Domain d1r2rb_: 1r2r B: [96876]
      3. 814290Domain d1r2rc_: 1r2r C: [96877]
      4. 814291Domain d1r2rd_: 1r2r D: [96878]
        complexed with dms, mo2, mo6, trs
    2. Domains for 1r2s:
      1. 814294Domain d1r2sa_: 1r2s A: [96879]
      2. 814295Domain d1r2sb_: 1r2s B: [96880]
      3. 814296Domain d1r2sc_: 1r2s C: [96881]
      4. 814297Domain d1r2sd_: 1r2s D: [96882]
    3. Domains for 1r2t:
      1. 814292Domain d1r2ta_: 1r2t A: [96883]
      2. 814293Domain d1r2tb_: 1r2t B: [96884]
  12. 814298Synthetic, hybrid between Escherichia coli and chicken TIM [51362] (1 PDB entry)
  13. 814303Thermoproteus tenax [TaxId:2271] [110342] (1 PDB entry)
    Uniprot Q8NKN9
  14. 814312Thermotoga maritima [TaxId:2336] [51365] (1 PDB entry)
  15. 814315Trypanosoma (Trypanozoon) brucei brucei (Trypanosoma brucei brucei) [TaxId:39700] [159375] (1 PDB entry)
  16. 814318Trypanosoma brucei [TaxId:5691] [51357] (19 PDB entries)
    1. Domains for 1ag1:
      1. 814332Domain d1ag1o_: 1ag1 O: [28474]
      2. 814333Domain d1ag1t_: 1ag1 T: [28475]
        complexed with po4
    2. Domains for 1dkw:
      1. 814339Domain d1dkwa_: 1dkw A: [28487]
        modified substrate binding site
      2. 814340Domain d1dkwb_: 1dkw B: [28488]
        modified substrate binding site
        complexed with tbu
    3. Domains for 1iig:
      1. 814334Domain d1iiga_: 1iig A: [62428]
      2. 814335Domain d1iigb_: 1iig B: [62429]
        complexed with 3pp
    4. Domains for 1iih:
      1. 814325Domain d1iiha_: 1iih A: [62430]
      2. 814326Domain d1iihb_: 1iih B: [62431]
        complexed with 3pg
    5. Domains for 1kv5:
      1. 814319Domain d1kv5a_: 1kv5 A: [73052]
      2. 814320Domain d1kv5b_: 1kv5 B: [73053]
        complexed with dtt, gol, pga, so4; mutant
    6. Domains for 1ml1:
      1. 814341Domain d1ml1a_: 1ml1 A: [28489]
      2. 814342Domain d1ml1c_: 1ml1 C: [28490]
      3. 814343Domain d1ml1e_: 1ml1 E: [28491]
      4. 814344Domain d1ml1g_: 1ml1 G: [28492]
      5. 814345Domain d1ml1i_: 1ml1 I: [28493]
      6. 814346Domain d1ml1k_: 1ml1 K: [28494]
        complexed with pga
    7. Domains for 1mss:
      1. 814355Domain d1mssa_: 1mss A: [28480]
        different dimerisation mode mutant
      2. 814356Domain d1mssb_: 1mss B: [28481]
        different dimerisation mode mutant
    8. Domains for 1tpd:
      1. 814327Domain d1tpda_: 1tpd A: [28470]
      2. 814328Domain d1tpdb_: 1tpd B: [28471]
    9. Domain for 1tpe:
    10. Domains for 1tpf:
      1. 814321Domain d1tpfa_: 1tpf A: [28467]
      2. 814322Domain d1tpfb_: 1tpf B: [28468]
        complexed with dms
    11. Domains for 1trd:
      1. 814337Domain d1trda_: 1trd A: [28476]
      2. 814338Domain d1trdb_: 1trd B: [28477]
        complexed with pgh
    12. Domain for 1tri:
    13. Domains for 1tsi:
      1. 814350Domain d1tsia_: 1tsi A: [28485]
      2. 814351Domain d1tsib_: 1tsi B: [28486]
        complexed with 4pb
    14. Domain for 1tti:
    15. Domain for 1ttj:
    16. Domains for 3tim:
      1. 814347Domain d3tima_: 3tim A: [28483]
      2. 814348Domain d3timb_: 3tim B: [28484]
    17. Domains for 4tim:
      1. 814330Domain d4tima_: 4tim A: [28472]
      2. 814331Domain d4timb_: 4tim B: [28473]
        complexed with 2pg
    18. Domains for 5tim:
      1. 814323Domain d5tima_: 5tim A: [28465]
      2. 814324Domain d5timb_: 5tim B: [28466]
        complexed with dtt, so4
    19. Domains for 6tim:
      1. 814352Domain d6tima_: 6tim A: [28495]
      2. 814353Domain d6timb_: 6tim B: [28496]
        complexed with g3p
  17. 814357Trypanosoma cruzi [TaxId:5693] [51358] (4 PDB entries)
    Uniprot P52270
    1. Domains for 1ci1:
      1. 814362Domain d1ci1a_: 1ci1 A: [28499]
        structure in hexane
      2. 814363Domain d1ci1b_: 1ci1 B: [28500]
        structure in hexane
        complexed with hex
    2. Domains for 1sux:
      1. 814358Domain d1suxa_: 1sux A: [106031]
      2. 814359Domain d1suxb_: 1sux B: [106032]
        complexed with bts, so4
    3. Domains for 1tcd:
      1. 814360Domain d1tcda_: 1tcd A: [28497]
      2. 814361Domain d1tcdb_: 1tcd B: [28498]
    4. Domains for 2oma:
      1. 814364Domain d2omaa1: 2oma A:2-251 [148869]
        automatically matched to d1suxa_
        complexed with cs1, peg, pge, so4
      2. 814365Domain d2omab1: 2oma B:2-251 [148870]
        automatically matched to d1suxa_
        complexed with cs1, peg, pge, so4
  18. 814366Vibrio marinus [TaxId:90736] [51364] (2 PDB entries)
    1. Domains for 1aw1:
      1. 814367Domain d1aw1a_: 1aw1 A: [28515]
      2. 814368Domain d1aw1b_: 1aw1 B: [28516]
      3. 814369Domain d1aw1d_: 1aw1 D: [28517]
      4. 814370Domain d1aw1e_: 1aw1 E: [28518]
      5. 814371Domain d1aw1g_: 1aw1 G: [28519]
      6. 814372Domain d1aw1h_: 1aw1 H: [28520]
      7. 814373Domain d1aw1j_: 1aw1 J: [28521]
      8. 814374Domain d1aw1k_: 1aw1 K: [28522]
        complexed with pga
    2. Domains for 1aw2:
      1. 814375Domain d1aw2a_: 1aw2 A: [28523]
      2. 814376Domain d1aw2b_: 1aw2 B: [28524]
      3. 814377Domain d1aw2d_: 1aw2 D: [28525]
      4. 814378Domain d1aw2e_: 1aw2 E: [28526]
      5. 814379Domain d1aw2g_: 1aw2 G: [28527]
      6. 814380Domain d1aw2h_: 1aw2 H: [28528]
      7. 814381Domain d1aw2j_: 1aw2 J: [28529]
      8. 814382Domain d1aw2k_: 1aw2 K: [28530]
        complexed with so4

More info for Protein Triosephosphate isomerase from c.1.1.1: Triosephosphate isomerase (TIM)

Timeline for Protein Triosephosphate isomerase from c.1.1.1: Triosephosphate isomerase (TIM):