Lineage for Protein: Triosephosphate isomerase

  1. Root: SCOP 1.63
  2. 235644Class c: Alpha and beta proteins (a/b) [51349] (117 folds)
  3. 235645Fold c.1: TIM beta/alpha-barrel [51350] (26 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 235646Superfamily c.1.1: Triosephosphate isomerase (TIM) [51351] (1 family) (S)
  5. 235647Family c.1.1.1: Triosephosphate isomerase (TIM) [51352] (1 protein)
  6. 235648Protein Triosephosphate isomerase [51353] (15 species)

Species:

  1. 235649Amoeba (Entamoeba histolytica) [82236] (1 PDB entry)
  2. 235652Archaeon Pyrococcus woesei [TaxId:2262] [63891] (1 PDB entry)
  3. 235661Bacillus stearothermophilus [TaxId:1422] [51363] (2 PDB entries)
    1. Domains for 1btm:
      1. 235664Domain d1btma_: 1btm A: [28513]
      2. 235665Domain d1btmb_: 1btm B: [28514]
        complexed with pga
    2. Domains for 2btm:
      1. 235662Domain d2btma_: 2btm A: [28511]
      2. 235663Domain d2btmb_: 2btm B: [28512]
        complexed with pga; mutant
  4. 235666Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51356] (7 PDB entries)
    1. Domains for 1i45:
      1. 235671Domain d1i45a_: 1i45 A: [61665]
      2. 235672Domain d1i45b_: 1i45 B: [61666]
        complexed with ftr; mutant
    2. Domains for 1ney:
      1. 235667Domain d1neya_: 1ney A: [80449]
      2. 235668Domain d1neyb_: 1ney B: [80450]
        complexed with 13p, ftr; mutant
    3. Domains for 1nf0:
      1. 235669Domain d1nf0a_: 1nf0 A: [80451]
      2. 235670Domain d1nf0b_: 1nf0 B: [80452]
        complexed with 13p, ftr; mutant
    4. Domains for 1ypi:
      1. 235675Domain d1ypia_: 1ypi A: [28459]
      2. 235676Domain d1ypib_: 1ypi B: [28460]
    5. Domains for 2ypi:
      1. 235677Domain d2ypia_: 2ypi A: [28461]
      2. 235678Domain d2ypib_: 2ypi B: [28462]
        complexed with pga
    6. Domains for 3ypi:
      1. 235679Domain d3ypia_: 3ypi A: [28463]
      2. 235680Domain d3ypib_: 3ypi B: [28464]
        complexed with pgh; mutant
    7. Domains for 7tim:
      1. 235673Domain d7tima_: 7tim A: [28457]
      2. 235674Domain d7timb_: 7tim B: [28458]
        complexed with pgh
  5. 235681Chicken (Gallus gallus) [TaxId:9031] [51354] (8 PDB entries)
    1. Domains for 1tim:
      1. 235696Domain d1tima_: 1tim A: [28453]
      2. 235697Domain d1timb_: 1tim B: [28454]
    2. Domains for 1tpb:
      1. 235686Domain d1tpb1_: 1tpb 1: [28445]
      2. 235687Domain d1tpb2_: 1tpb 2: [28446]
        complexed with pgh; mutant
    3. Domains for 1tpc:
      1. 235688Domain d1tpc1_: 1tpc 1: [28447]
      2. 235689Domain d1tpc2_: 1tpc 2: [28448]
        complexed with pgh; mutant
    4. Domains for 1tph:
      1. 235682Domain d1tph1_: 1tph 1: [28439]
      2. 235683Domain d1tph2_: 1tph 2: [28440]
        complexed with pgh
    5. Domains for 1tpu:
      1. 235684Domain d1tpua_: 1tpu A: [28441]
      2. 235685Domain d1tpub_: 1tpu B: [28442]
        complexed with pgh; mutant
    6. Domains for 1tpv:
      1. 235690Domain d1tpva_: 1tpv A: [28443]
      2. 235691Domain d1tpvb_: 1tpv B: [28444]
        complexed with pgh; mutant
    7. Domains for 1tpw:
      1. 235692Domain d1tpwa_: 1tpw A: [28449]
      2. 235693Domain d1tpwb_: 1tpw B: [28450]
        complexed with pgh; mutant
    8. Domains for 8tim:
      1. 235694Domain d8tima_: 8tim A: [28451]
      2. 235695Domain d8timb_: 8tim B: [28452]
        complexed with so4
  6. 235698Escherichia coli [TaxId:562] [51361] (1 PDB entry)
  7. 235701Human (Homo sapiens) [TaxId:9606] [51355] (1 PDB entry)
  8. 235704Hybrid between Escherichia coli and chicken TIM [51362] (1 PDB entry)
  9. 235709Leishmania mexicana [TaxId:5665] [51360] (4 PDB entries)
    1. Domain for 1amk:
    2. Domain for 1if2:
    3. Domain for 1n55:
      • 235710Domain d1n55a_: 1n55 A: [80007]
        ultra-high resolution structure
        complexed with acy, gol, pga; mutant
    4. Domain for 1qds:
  10. 235714Nematode (Caenorhabditis elegans) [TaxId:6239] [82235] (1 PDB entry)
  11. 235717Plasmodium falciparum [51359] (5 PDB entries)
    1. Domain for 1lyx:
    2. Domains for 1lzo:
      1. 235725Domain d1lzoa_: 1lzo A: [78307]
      2. 235726Domain d1lzob_: 1lzo B: [78308]
      3. 235727Domain d1lzoc_: 1lzo C: [78309]
      4. 235728Domain d1lzod_: 1lzo D: [78310]
        complexed with pga
    3. Domains for 1m7o:
      1. 235723Domain d1m7oa_: 1m7o A: [78740]
      2. 235724Domain d1m7ob_: 1m7o B: [78741]
        complexed with 3pg
    4. Domains for 1m7p:
      1. 235721Domain d1m7pa_: 1m7p A: [78742]
      2. 235722Domain d1m7pb_: 1m7p B: [78743]
        complexed with g3p
    5. Domains for 1ydv:
      1. 235719Domain d1ydva_: 1ydv A: [28501]
      2. 235720Domain d1ydvb_: 1ydv B: [28502]
  12. 235729Thermotoga maritima [TaxId:243274] [51365] (1 PDB entry)
  13. 235732Trypanosoma brucei [TaxId:5691] [51357] (19 PDB entries)
    1. Domains for 1ag1:
      1. 235744Domain d1ag1o_: 1ag1 O: [28474]
      2. 235745Domain d1ag1t_: 1ag1 T: [28475]
        complexed with po4
    2. Domains for 1dkw:
      1. 235764Domain d1dkwa_: 1dkw A: [28487]
      2. 235765Domain d1dkwb_: 1dkw B: [28488]
        modified substrate binding site
        complexed with tbu
    3. Domains for 1iig:
      1. 235748Domain d1iiga_: 1iig A: [62428]
      2. 235749Domain d1iigb_: 1iig B: [62429]
        complexed with 3pp
    4. Domains for 1iih:
      1. 235740Domain d1iiha_: 1iih A: [62430]
      2. 235741Domain d1iihb_: 1iih B: [62431]
        complexed with 3pg
    5. Domains for 1kv5:
      1. 235733Domain d1kv5a_: 1kv5 A: [73052]
      2. 235734Domain d1kv5b_: 1kv5 B: [73053]
        complexed with dtt, gol, pga, so4; mutant
    6. Domains for 1ml1:
      1. 235758Domain d1ml1a_: 1ml1 A: [28489]
      2. 235759Domain d1ml1c_: 1ml1 C: [28490]
      3. 235760Domain d1ml1e_: 1ml1 E: [28491]
      4. 235761Domain d1ml1g_: 1ml1 G: [28492]
      5. 235762Domain d1ml1i_: 1ml1 I: [28493]
      6. 235763Domain d1ml1k_: 1ml1 K: [28494]
        complexed with pga
    7. Domains for 1mss:
      1. 235769Domain d1mssa_: 1mss A: [28480]
      2. 235770Domain d1mssb_: 1mss B: [28481]
        different dimerisation mode mutant
    8. Domains for 1tpd:
      1. 235742Domain d1tpda_: 1tpd A: [28470]
      2. 235743Domain d1tpdb_: 1tpd B: [28471]
    9. Domain for 1tpe:
    10. Domains for 1tpf:
      1. 235737Domain d1tpfa_: 1tpf A: [28467]
      2. 235738Domain d1tpfb_: 1tpf B: [28468]
        complexed with dms
    11. Domains for 1trd:
      1. 235750Domain d1trda_: 1trd A: [28476]
      2. 235751Domain d1trdb_: 1trd B: [28477]
        complexed with pgh
    12. Domain for 1tri:
    13. Domains for 1tsi:
      1. 235756Domain d1tsia_: 1tsi A: [28485]
      2. 235757Domain d1tsib_: 1tsi B: [28486]
        complexed with 4pb
    14. Domain for 1tti:
    15. Domain for 1ttj:
    16. Domains for 3tim:
      1. 235754Domain d3tima_: 3tim A: [28483]
      2. 235755Domain d3timb_: 3tim B: [28484]
    17. Domains for 4tim:
      1. 235746Domain d4tima_: 4tim A: [28472]
      2. 235747Domain d4timb_: 4tim B: [28473]
        complexed with 2pg
    18. Domains for 5tim:
      1. 235735Domain d5tima_: 5tim A: [28465]
      2. 235736Domain d5timb_: 5tim B: [28466]
        complexed with dtt, so4
    19. Domains for 6tim:
      1. 235766Domain d6tima_: 6tim A: [28495]
      2. 235767Domain d6timb_: 6tim B: [28496]
        complexed with g3p
  14. 235771Trypanosoma cruzi [TaxId:5693] [51358] (2 PDB entries)
    1. Domains for 1ci1:
      1. 235774Domain d1ci1a_: 1ci1 A: [28499]
      2. 235775Domain d1ci1b_: 1ci1 B: [28500]
        structure in hexane
        complexed with hex
    2. Domains for 1tcd:
      1. 235772Domain d1tcda_: 1tcd A: [28497]
      2. 235773Domain d1tcdb_: 1tcd B: [28498]
  15. 235776Vibrio marinus [TaxId:90736] [51364] (2 PDB entries)
    1. Domains for 1aw1:
      1. 235777Domain d1aw1a_: 1aw1 A: [28515]
      2. 235778Domain d1aw1b_: 1aw1 B: [28516]
      3. 235779Domain d1aw1d_: 1aw1 D: [28517]
      4. 235780Domain d1aw1e_: 1aw1 E: [28518]
      5. 235781Domain d1aw1g_: 1aw1 G: [28519]
      6. 235782Domain d1aw1h_: 1aw1 H: [28520]
      7. 235783Domain d1aw1j_: 1aw1 J: [28521]
      8. 235784Domain d1aw1k_: 1aw1 K: [28522]
        complexed with pga
    2. Domains for 1aw2:
      1. 235785Domain d1aw2a_: 1aw2 A: [28523]
      2. 235786Domain d1aw2b_: 1aw2 B: [28524]
      3. 235787Domain d1aw2d_: 1aw2 D: [28525]
      4. 235788Domain d1aw2e_: 1aw2 E: [28526]
      5. 235789Domain d1aw2g_: 1aw2 G: [28527]
      6. 235790Domain d1aw2h_: 1aw2 H: [28528]
      7. 235791Domain d1aw2j_: 1aw2 J: [28529]
      8. 235792Domain d1aw2k_: 1aw2 K: [28530]
        complexed with so4

More info for Protein Triosephosphate isomerase from c.1.1.1: Triosephosphate isomerase (TIM)

Timeline for Protein Triosephosphate isomerase from c.1.1.1: Triosephosphate isomerase (TIM):