SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Class c: Alpha and beta proteins (a/b)

  1. Root: SCOP 1.55
  2. 18352Class c: Alpha and beta proteins (a/b) [51349] (97 folds)

Folds:

  1. 18353c.1: TIM beta/alpha-barrel [51350] (23 superfamilies)
  2. 19977c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
  3. 20781c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
  4. 21132c.4: Nucleotide-binding domain [51970] (1 superfamily)
  5. 21197c.5: N-terminal domain of MurD (UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase) [51983] (1 superfamily)
  6. 21208c.6: Cellulases [51988] (1 superfamily)
  7. 21232c.7: PFL-like glycyl radical enzymes [51997] (1 superfamily)
  8. 21274c.8: The "swivelling" beta/beta/alpha domain [52008] (5 superfamilies)
  9. 21426c.9: Barstar-like [52037] (2 superfamilies)
  10. 21460c.10: Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [52046] (2 superfamilies)
  11. 21517c.11: Outer arm dynein light chain 1 [52074] (1 superfamily)
  12. 21523c.12: Ribosomal proteins L15p and L18e [52079] (1 superfamily)
  13. 21532c.13: SpoIIaa-like [52086] (2 superfamilies)
  14. 21544c.14: ClpP/crotonase [52095] (1 superfamily)
  15. 21601c.15: BRCT domain [52112] (1 superfamily)
  16. 21611c.16: beta-subunit of the lumazine synthase/riboflavin synthase complex [52120] (1 superfamily)
  17. 21684c.17: Caspase-like [52128] (1 superfamily)
  18. 21711c.18: DNA glycosylase [52140] (1 superfamily)
  19. 21745c.19: Catalytic domain of malonyl-CoA ACP transacylase [52150] (1 superfamily)
  20. 21751c.20: Initiation factor IF2/eIF5b, domain 3 [52155] (1 superfamily)
  21. 21759c.21: Ribosomal protein L13 [52160] (1 superfamily)
  22. 21765c.22: Ribosomal protein L4 [52165] (1 superfamily)
  23. 21773c.23: Flavodoxin-like [52171] (16 superfamilies)
  24. 22377c.24: Methylglyoxal synthase-like [52334] (1 superfamily)
  25. 22422c.25: Ferredoxin reductase-like, C-terminal NADP-linked domain [52342] (1 superfamily)
  26. 22501c.26: Adenine nucleotide alpha hydrolase-like [52373] (3 superfamilies)
  27. 22604c.27: Pyrimidine nucleoside phosphorylase central domain [52417] (1 superfamily)
  28. 22618c.28: N-terminal domain of DNA photolyase [52424] (1 superfamily)
  29. 22627c.29: ETFP adenine nucleotide-binding domain-like [52430] (1 superfamily)
  30. 22644c.30: Biotin carboxylase N-terminal domain-like [52439] (1 superfamily)
  31. 22757c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
  32. 22803c.32: Tubulin, GTPase domain [52489] (1 superfamily)
  33. 22815c.33: Cysteine hydrolase [52498] (1 superfamily)
  34. 22829c.34: Halotolerance protein Hal3 [52506] (1 superfamily)
  35. 22835c.35: Glucosamine 6-phosphate deaminase/isomerase [52511] (1 superfamily)
  36. 22854c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
  37. 22942c.37: P-loop containing nucleotide triphosphate hydrolases [52539] (1 superfamily)
  38. 23766c.38: Fructose permease, subunit IIb [52727] (1 superfamily)
  39. 23772c.39: Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) [52732] (1 superfamily)
  40. 23779c.40: Methylesterase CheB, C-terminal domain [52737] (1 superfamily)
  41. 23787c.41: Subtilisin-like [52742] (1 superfamily)
  42. 23890c.42: Arginase/deacetylase [52767] (1 superfamily)
  43. 23950c.43: CoA-dependent acyltransferases [52776] (1 superfamily)
  44. 23986c.44: Phosphotyrosine protein phosphatases I-like [52787] (2 superfamilies)
  45. 24013c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
  46. 24082c.46: Rhodanese/Cell cycle control phosphatase [52820] (1 superfamily)
  47. 24115c.47: Thioredoxin fold [52832] (3 superfamilies)
  48. 24575c.48: Transketolase C-terminal domain-like [52921] (1 superfamily)
  49. 24606c.49: Pyruvate kinase C-terminal domain-like [52934] (2 superfamilies)
  50. 24678c.50: Leucine aminopeptidase, N-terminal domain [52948] (1 superfamily)
  51. 24691c.51: Anticodon-binding domain-like [52953] (4 superfamilies)
  52. 24772c.52: Restriction endonuclease-like [52979] (3 superfamilies)
  53. 24949c.53: Resolvase-like [53040] (2 superfamilies)
  54. 25001c.54: IIA domain of mannose transporter, IIA-Man [53061] (1 superfamily)
  55. 25007c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
  56. 25480c.56: Phosphorylase/hydrolase-like [53162] (6 superfamilies)
  57. 25644c.57: Molybdenumm cofactor biosynthesis protein MogA [53217] (1 superfamily)
  58. 25651c.58: Aminoacid dehydrogenase-like, N-terminal domain [53222] (1 superfamily)
  59. 25758c.59: Glutamate ligase domain [53243] (1 superfamily)
  60. 25777c.60: Phosphoglycerate mutase-like [53253] (1 superfamily)
  61. 25845c.61: PRTase-like [53270] (1 superfamily)
  62. 25985c.62: Integrin A (or I) domain [53299] (1 superfamily)
  63. 26032c.63: Glutaconate-CoA transferase subunits [53315] (1 superfamily)
  64. 26043c.64: Pyruvate-ferredoxin oxidoreductase, PFOR, domain III [53322] (1 superfamily)
  65. 26052c.65: Formyltransferase [53327] (1 superfamily)
  66. 26076c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
  67. 26196c.67: PLP-dependent transferases [53382] (1 superfamily)
  68. c.68: Nucleotide-diphospho-sugar transferases [53447] (1 superfamily)
  69. 26618c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
  70. 26963c.70: Nucleoside hydrolase [53589] (1 superfamily)
  71. 26980c.71: Dihydrofolate reductases [53596] (1 superfamily)
  72. 27104c.72: Ribokinase-like [53612] (2 superfamilies)
  73. 27159c.73: Carbamate kinase-like [53632] (1 superfamily)
  74. 27171c.74: Class II aldolase [53638] (1 superfamily)
  75. 27193c.75: Cytosolic phospholipase A2 catalytic domain [53643] (1 superfamily)
  76. 27200c.76: Phosphatase/sulphatase [53648] (1 superfamily)
  77. 27255c.77: Isocitrate & isopropylmalate dehydrogenases [53658] (1 superfamily)
  78. 27322c.78: ATC-like [53670] (2 superfamilies)
  79. 27517c.79: Tryptophan synthase beta subunit-like PLP-dependent enzymes [53685] (1 superfamily)
  80. 27562c.80: SIS domain [53696] (1 superfamily)
  81. 27580c.81: Formate dehydrogenase/DMSO reductase, domains 1-3 [53705] (1 superfamily)
  82. 27618c.82: Aldehyde reductase (dehydrogenase), ALDH [53719] (1 superfamily)
  83. 27688c.83: Aconitase, first 3 domains [53731] (1 superfamily)
  84. 27709c.84: Phosphoglucomutase, first 3 domains [53737] (1 superfamily)
  85. 27750c.85: L-fucose isomerase, N-terminal and second domains [53742] (1 superfamily)
  86. 27761c.86: Phosphoglycerate kinase [53747] (1 superfamily)
  87. 27778c.87: UDP-Glycosyltransferase/glycogen phosphorylase [53755] (1 superfamily)
  88. 27887c.88: Glutaminase/Asparaginase [53773] (1 superfamily)
  89. 27922c.89: Phosphofructokinase [53783] (1 superfamily)
  90. 27940c.90: Cobalt precorrin-4 methyltransferase CbiF [53789] (1 superfamily)
  91. 27947c.91: Phosphoenolpyruvate carboxykinase (ATP-oxaloacetate carboxy-liase) [53794] (1 superfamily)
  92. 27955c.92: Chelatase-like [53799] (2 superfamilies)
  93. 28022c.93: Periplasmic binding protein-like I [53821] (1 superfamily)
  94. 28131c.94: Periplasmic binding protein-like II [53849] (1 superfamily)
  95. c.95: Thiolase-like [53900] (1 superfamily)
  96. 28498c.96: Fe-only hydrogenase [53919] (1 superfamily)
  97. 28510c.97: Cytidine deaminase [53926] (1 superfamily)

More info for Class c: Alpha and beta proteins (a/b)

Timeline for Class c: Alpha and beta proteins (a/b):