SCOPe 2.01: Family b.82.3.2: cAMP-binding domain

Lineage for Family b.82.3.2: cAMP-binding domain

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
   one turn of helix is made by two pairs of antiparallel strands linked with short turns
   has appearance of a sandwich of distinct architecture and jelly-roll topology

4. Superfamily b.82.3: cAMP-binding domain-like [51206] (3 families)

5. Family b.82.3.2: cAMP-binding domain [51210] (13 proteins)
   Pfam PF00027

Proteins:

1. Catabolite gene activator protein, N-terminal domain [51211] (1 species)

   • Species Escherichia coli [TaxId:562] [51212] (19 PDB entries)

2. Chlorophenol reduction protein CprK [159314] (2 species)

   1. Species Desulfitobacterium dehalogenans [TaxId:36854] [159316] (1 PDB entry)
      Uniprot Q9LAS2 19-147

   2. Species Desulfitobacterium hafniense [TaxId:49338] [159315] (3 PDB entries)
      Uniprot Q18R04 3-147! Uniprot Q18R04 9-147

3. CRP-like transcriptional regulator TM1171, N-terminal domain [101991] (1 species)

   • Species Thermotoga maritima [TaxId:2336] [101992] (1 PDB entry)

4. Cyclic AMP receptor-like protein Vfr [159312] (1 species)

   • Species Pseudomonas aeruginosa [TaxId:287] [159313] (1 PDB entry)
     Uniprot P55222 9-142

5. HCN pacemaker channel [101993] (1 species)
   potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel

   • Species Mouse (Mus musculus) [TaxId:10090] [101994] (5 PDB entries)

6. Probable cyclic nucleotide-gated ion channel 6 [117323] (1 species)

   • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [117324] (1 PDB entry)
     Uniprot O82226 509-632

7. Probable transcription regulator BT4300, N-terminal domain [141639] (1 species)

   • Species Bacteroides thetaiotaomicron [TaxId:818] [141640] (1 PDB entry)
     Uniprot Q89ZS6 1-147

8. Putative ion channel CnbD [110321] (1 species)

   • Species Mesorhizobium loti [TaxId:381] [110322] (2 PDB entries)
     Uniprot Q98GN8 218-350 # mll3241

9. Regulatory domain of Epac2, domains 1 and 3 [82197] (1 species)
   duplication: two homologous domains of this fold are separated in the sequence by a DEP domain

   • Species Mouse (Mus musculus) [TaxId:10090] [82198] (1 PDB entry)

10. Regulatory subunit of Protein kinase A [51213] (2 species)
    duplication: consists of two similar domains

    1. Species Cow (Bos taurus) [TaxId:9913] [51214] (4 PDB entries)
       Uniprot P00514 109-376

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [63861] (1 PDB entry)

11. Transcriptional regulator PG0396, N-terminal domain [141643] (1 species)

    • Species Porphyromonas gingivalis [TaxId:837] [141644] (1 PDB entry)
      Uniprot Q7MAW7 10-151

12. Transcriptional regulator TTHA1359, N-terminal domain [141641] (1 species)

    • Species Thermus thermophilus [TaxId:274] [141642] (1 PDB entry)
      Uniprot Q5SIL0 6-117

13. automated matches [190352] (5 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [189505] (3 PDB entries)

    2. Species Mesorhizobium loti [TaxId:381] [188511] (1 PDB entry)

    3. Species Mouse (Mus musculus) [TaxId:10090] [187178] (3 PDB entries)

    4. Species Purple sea urchin (Strongylocentrotus purpuratus) [TaxId:7668] [188850] (1 PDB entry)

    5. Species Rhizobium loti [TaxId:381] [187243] (2 PDB entries)

More info for Family b.82.3.2: cAMP-binding domain

Timeline for Family b.82.3.2: cAMP-binding domain:

• Family b.82.3.2: cAMP-binding domain first appeared (with stable ids) in SCOP 1.55
  
• Family b.82.3.2: cAMP-binding domain appears in SCOP 1.75
  
• Family b.82.3.2: cAMP-binding domain appears in SCOPe 2.02
  
• Family b.82.3.2: cAMP-binding domain appears in the current release, SCOPe 2.08