SCOPe 2.06: Family b.69.4.1: WD40-repeat

Lineage for Family b.69.4.1: WD40-repeat

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.69: 7-bladed beta-propeller [50964] (15 superfamilies)
   consists of seven 4-stranded beta-sheet motifs; meander

4. Superfamily b.69.4: WD40 repeat-like [50978] (4 families)
   also contains 8-bladed propellers

5. Family b.69.4.1: WD40-repeat [50979] (13 proteins)
   this is a repeat family; one repeat unit is 1tyq C:201-243 found in domain

Proteins:

1. Actin interacting protein 1 [89378] (2 species)
   14 repeats are arranged into two seven-bladed beta-propeller domains swapped with the N-terminal strands

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89380] (2 PDB entries)

   2. Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89379] (2 PDB entries)

2. Antiviral protein Ski8 (Ski8p) [110287] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [110288] (2 PDB entries)
     Uniprot Q02793

3. Arp2/3 complex 41 kDa subunit ARPC1 [69313] (1 species)

   • Species Cow (Bos taurus) [TaxId:9913] [69314] (3 PDB entries)
     Uniprot Q58CQ2

4. beta1-subunit of the signal-transducing G protein heterotrimer [50980] (1 species)

   • Species Cow (Bos taurus) [TaxId:9913] [50981] (29 PDB entries)

5. Cdc4 propeller domain [82169] (1 species)
   8-bladed beta-propeller without perfect 8-fold symmetry

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82170] (2 PDB entries)

6. Chromatin Assembly Factor 1 (CAF1) p55 subunit [310796] (1 species)
   Includes Pfam PF12265

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [311056] (2 PDB entries)

7. F-box/WD repeat-containing protein 7, FBXW7 [159259] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [159260] (3 PDB entries)
     Uniprot Q969H0 365-706

8. F-box/WD-repeat protein 1 (beta-TRCP1) [89376] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89377] (1 PDB entry)

9. Groucho/tle1, C-terminal domain [75009] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75010] (4 PDB entries)

10. Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1 or RACK1) [267639] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [267698] (2 PDB entries)

11. Platelet-activating factor acetylhydrolase IB subunit alpha [159257] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [159258] (1 PDB entry)
      Uniprot P43034 91-407

12. Tup1, C-terminal domain [50983] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [50984] (1 PDB entry)

13. automated matches [190346] (4 species)
    not a true protein

    1. Species Cow (Bos taurus) [TaxId:9913] [187173] (14 PDB entries)

    2. Species Cryptococcus neoformans [TaxId:235443] [270243] (1 PDB entry)

    3. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [311262] (1 PDB entry)

    4. Species Human (Homo sapiens) [TaxId:9606] [311290] (1 PDB entry)

More info for Family b.69.4.1: WD40-repeat

Timeline for Family b.69.4.1: WD40-repeat:

• Family b.69.4.1: WD40-repeat first appeared (with stable ids) in SCOP 1.55, called Family b.69.4.1: Trp-Asp repeat (WD-repeat)
  
• Family b.69.4.1: WD40-repeat appears in SCOPe 2.05
  
• Family b.69.4.1: WD40-repeat appears in SCOPe 2.07
  
• Family b.69.4.1: WD40-repeat appears in the current release, SCOPe 2.08