SCOP 1.75: Family b.69.4.1: WD40-repeat

Lineage for Family b.69.4.1: WD40-repeat

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.69: 7-bladed beta-propeller [50964] (14 superfamilies)
   consists of seven 4-stranded beta-sheet motifs; meander

4. Superfamily b.69.4: WD40 repeat-like [50978] (2 families)
   also contains 8-bladed propellers

5. Family b.69.4.1: WD40-repeat [50979] (10 proteins)
   this is a repeat family; one repeat unit is 1tyq C:201-243 found in domain

Proteins:

1. Actin interacting protein 1 [89378] (2 species)
   14 repeats are arranged into two seven-bladed beta-propeller domains swapped with the N-terminal strands

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89380] (2 PDB entries)

   2. Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89379] (2 PDB entries)

2. Antiviral protein Ski8 (Ski8p) [110287] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [110288] (2 PDB entries)
     Uniprot Q02793

3. Arp2/3 complex 41 kDa subunit ARPC1 [69313] (1 species)

   • Species Cow (Bos taurus) [TaxId:9913] [69314] (10 PDB entries)
     Uniprot Q58CQ2

4. beta1-subunit of the signal-transducing G protein heterotrimer [50980] (2 species)

   1. Species Cow (Bos taurus) [TaxId:9913] [50981] (11 PDB entries)

   2. Species Homo sapiens [TaxId:9606] [159256] (1 PDB entry)

5. Cdc4 propeller domain [82169] (1 species)
   8-bladed beta-propeller without perfect 8-fold symmetry

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82170] (1 PDB entry)

6. F-box/WD repeat-containing protein 7, FBXW7 [159259] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [159260] (3 PDB entries)
     Uniprot Q969H0 365-706

7. F-box/WD-repeat protein 1 (beta-TRCP1) [89376] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89377] (1 PDB entry)

8. Groucho/tle1, C-terminal domain [75009] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75010] (3 PDB entries)

9. Platelet-activating factor acetylhydrolase IB subunit alpha [159257] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [159258] (1 PDB entry)
     Uniprot P43034 91-407

10. Tup1, C-terminal domain [50983] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [50984] (1 PDB entry)

More info for Family b.69.4.1: WD40-repeat

Timeline for Family b.69.4.1: WD40-repeat:

• Family b.69.4.1: WD40-repeat first appeared (with stable ids) in SCOP 1.55, called Family b.69.4.1: Trp-Asp repeat (WD-repeat)
  
• Family b.69.4.1: WD40-repeat appears in SCOP 1.73
  
• Family b.69.4.1: WD40-repeat appears in SCOPe 2.01
  
• Family b.69.4.1: WD40-repeat appears in the current release, SCOPe 2.08