SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Superfamily b.69.4: WD40 repeat-like

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2065823Fold b.69: 7-bladed beta-propeller [50964] (15 superfamilies)
    consists of seven 4-stranded beta-sheet motifs; meander
  4. 2065971Superfamily b.69.4: WD40 repeat-like [50978] (4 families) (S)
    also contains 8-bladed propellers

Families:

  1. 2065972b.69.4.1: WD40-repeat [50979] (13 protein domains)
  2. 2066095b.69.4.2: Cell cycle arrest protein BUB3 [110289] (2 protein domains)
    possibly related to the WD-repeat family; both sequence similarity between the blades and the WD40 repeat signature are very weak
  3. 2066110b.69.4.3: DDB1-like [254176] (1 protein)
    PubMed 16413485; combines Pfam PF10433 and Pfam PF03178. Distant homology to WD40 proposed in PubMed 10982878
  4. 2066122b.69.4.0: automated matches [191412] (1 protein)
    not a true family

More info for Superfamily b.69.4: WD40 repeat-like

Timeline for Superfamily b.69.4: WD40 repeat-like: