SCOPe 2.03: Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase)

Lineage for Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.62: Cyclophilin-like [50890] (1 superfamily)
   barrel, closed; n=8, S=10; complex topology

4. Superfamily b.62.1: Cyclophilin-like [50891] (5 families)

5. Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase) [50892] (13 proteins)
   automatically mapped to Pfam PF00160

Proteins:

1. Cyclophilin (eukaryotic) [50893] (13 species)

   1. Species Aspergillus fumigatus [TaxId:5085] [141499] (1 PDB entry)
      Uniprot Q9Y7F6 8-178

   2. Species Baker's yeast (Saccharomyces cerevisiae), variant A [TaxId:4932] [101878] (1 PDB entry)

   3. Species Caenorhabditis elegans, isoform 3 [TaxId:6239] [50899] (3 PDB entries)

   4. Species Caenorhabditis elegans, isoform 5 [TaxId:6239] [82161] (1 PDB entry)

   5. Species Human (Homo sapiens), U4/U6 snRNP-specific cyclophilin snucyp-20 [TaxId:9606] [50896] (2 PDB entries)

   6. Species Human (Homo sapiens), variant A [TaxId:9606] [50894] (58 PDB entries)
      Uniprot P05092

   7. Species Human (Homo sapiens), variant B [TaxId:9606] [50895] (1 PDB entry)

   8. Species Human (Homo sapiens), variant C [TaxId:9606] [141498] (1 PDB entry)
      Uniprot P45877 32-212

   9. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [50900] (2 PDB entries)

   10. Species Mouse (Mus musculus), variant C [TaxId:10090] [50897] (1 PDB entry)

   11. Species Nematode (Brugia malayi) [TaxId:6279] [50898] (3 PDB entries)

   12. Species Plasmodium yoelii [TaxId:5861] [141500] (1 PDB entry)
       Uniprot Q7RSH5 25-210

   13. Species Trypanosoma cruzi [TaxId:5693] [117269] (2 PDB entries)
       Uniprot Q4DPB9 30-194

2. Cyclophilin 40 isomerase domain [63814] (1 species)
   the other domain is formed by TPR repeats

   • Species Cow (Bos taurus) [TaxId:9913] [63815] (2 PDB entries)

3. Cyclophilin-like allergen Mal s 6 [141501] (1 species)

   • Species Malassezia sympodialis [TaxId:76777] [141502] (1 PDB entry)
     Uniprot O93970 1-162

4. Cyclophilin-like protein PPIL3B [141509] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141510] (3 PDB entries)
     Uniprot Q9H2H8 1-160

5. Cyclophilin-like protein PY00693 [141507] (1 species)

   • Species Plasmodium yoelii [TaxId:5861] [141508] (1 PDB entry)
     Uniprot Q7RRM6 29-197

6. Mitochondrial peptidyl-prolyl cis-trans isomerase, cyclophilin F [141511] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141512] (25 PDB entries)
     Uniprot P30405 44-207

7. Peptidyl-prolyl cis-trans isomerase A, PpiA [50901] (2 species)

   1. Species Escherichia coli [TaxId:562] [50902] (6 PDB entries)
      Uniprot P20752

   2. Species Mycobacterium tuberculosis [TaxId:1773] [117270] (1 PDB entry)
      Uniprot P65762

8. Peptidyl-prolyl cis-trans isomerase E, PPIE, C-terminal domain [141503] (1 species)
   N-terminal domain belongs to the RBD family (54929)

   • Species Human (Homo sapiens) [TaxId:9606] [141504] (1 PDB entry)
     Uniprot Q9UNP9 138-301
     structure of the N-terminal RBD is known, PDB 2cqb

9. Peptidyl-prolyl cis-trans isomerase-like 1, PPIL1 [141517] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141518] (1 PDB entry)
     Uniprot Q9Y3C6 1-166

10. Peptidyl-prolyl cis-trans isomerase-like 2, Cyclophilin-60, PPI domain [141505] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141506] (1 PDB entry)
      Uniprot Q13356 280-457

11. Peptidylprolyl isomerase domain and WD repeat-containing protein 1, PPWD1, C-terminal domain [141515] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141516] (1 PDB entry)
      Uniprot Q96BP3 483-646

12. Putative cyclophilin PFE0505w [141513] (1 species)
    PPWD1 homologue

    • Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [141514] (1 PDB entry)
      Uniprot Q8I402 592-746

13. automated matches [190077] (16 species)
    not a true protein

    1. Species Aspergillus fumigatus [TaxId:5085] [187014] (1 PDB entry)

    2. Species Azotobacter vinelandii [TaxId:322710] [195875] (1 PDB entry)

    3. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [186798] (1 PDB entry)

    4. Species Blood fluke (Schistosoma mansoni) [TaxId:6183] [187342] (2 PDB entries)

    5. Species Burkholderia pseudomallei [TaxId:320372] [189985] (1 PDB entry)

    6. Species Fungus (Encephalitozoon cuniculi) [TaxId:6035] [226758] (1 PDB entry)

    7. Species Horse (Equus caballus) [TaxId:9796] [226528] (2 PDB entries)

    8. Species Human (Homo sapiens) [TaxId:9606] [186915] (14 PDB entries)

    9. Species Leishmania donovani [TaxId:5661] [187796] (2 PDB entries)

    10. Species Leishmania major [TaxId:5664] [187822] (1 PDB entry)

    11. Species Moniliophthora perniciosa [TaxId:153609] [189814] (2 PDB entries)

    12. Species Nematode (Brugia malayi) [TaxId:6279] [193907] (1 PDB entry)

    13. Species Nematode (Caenorhabditis elegans) [TaxId:6239] [187239] (2 PDB entries)

    14. Species Piriformospora indica [TaxId:65672] [197083] (1 PDB entry)

    15. Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [189056] (4 PDB entries)

    16. Species Wheat (Triticum aestivum) [TaxId:4565] [196725] (1 PDB entry)

More info for Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase)

Timeline for Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase):

• Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase) first appeared (with stable ids) in SCOP 1.55
  
• Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase) appears in SCOPe 2.02
  
• Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase) appears in SCOPe 2.04
  
• Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase) appears in the current release, SCOPe 2.08