SCOP 1.73: Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase)

Lineage for Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.62: Cyclophilin-like [50890] (1 superfamily)
   barrel, closed; n=8, S=10; complex topology

4. Superfamily b.62.1: Cyclophilin-like [50891] (3 families)

5. Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase) [50892] (12 proteins)

Proteins:

1. Cyclophilin (eukaryotic) [50893] (13 species)

   1. Species Aspergillus fumigatus [TaxId:5085] [141499] (1 PDB entry)

   2. Species Baker's yeast (Saccharomyces cerevisiae), variant A [TaxId:4932] [101878] (2 PDB entries)

   3. Species Caenorhabditis elegans, isoform 3 [TaxId:6239] [50899] (3 PDB entries)

   4. Species Caenorhabditis elegans, isoform 5 [TaxId:6239] [82161] (1 PDB entry)

   5. Species Human (Homo sapiens), U4/U6 snRNP-specific cyclophilin snucyp-20 [TaxId:9606] [50896] (2 PDB entries)

   6. Species Human (Homo sapiens), variant A [TaxId:9606] [50894] (48 PDB entries)

   7. Species Human (Homo sapiens), variant B [TaxId:9606] [50895] (1 PDB entry)

   8. Species Human (Homo sapiens), variant C [TaxId:9606] [141498] (1 PDB entry)

   9. Species Mouse (Mus musculus), variant C [TaxId:10090] [50897] (1 PDB entry)

   10. Species Nematode (Brugia malayi) [TaxId:6279] [50898] (3 PDB entries)

   11. Species Plasmodium falciparum [TaxId:5833] [50900] (2 PDB entries)

   12. Species Plasmodium yoelii [TaxId:5861] [141500] (1 PDB entry)

   13. Species Trypanosoma cruzi [TaxId:5693] [117269] (2 PDB entries)

2. Cyclophilin 40 isomerase domain [63814] (1 species)
   the other domain is formed by TPR repeats

   • Species Cow (Bos taurus) [TaxId:9913] [63815] (2 PDB entries)

3. Cyclophilin-like allergen Mal s 6 [141501] (1 species)

   • Species Malassezia sympodialis [TaxId:76777] [141502] (1 PDB entry)

4. Cyclophilin-like protein PPIL3B [141509] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141510] (1 PDB entry)

5. Cyclophilin-like protein PY00693 [141507] (1 species)

   • Species Plasmodium yoelii [TaxId:5861] [141508] (1 PDB entry)

6. Mitochondrial peptidyl-prolyl cis-trans isomerase, cyclophilin F [141511] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141512] (2 PDB entries)

7. Peptidyl-prolyl cis-trans isomerase A, PpiA [50901] (2 species)

   1. Species Escherichia coli [TaxId:562] [50902] (6 PDB entries)

   2. Species Mycobacterium tuberculosis [TaxId:1773] [117270] (1 PDB entry)

8. Peptidyl-prolyl cis-trans isomerase E, PPIE, C-terminal domain [141503] (1 species)
   N-terminal domain belongs to the RBD family (scop_fa 54929)

   • Species Human (Homo sapiens) [TaxId:9606] [141504] (2 PDB entries)
     structure of the N-terminal RBD is known, PDB 2cqb

9. Peptidyl-prolyl cis-trans isomerase-like 1, PPIL1 [141517] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141518] (1 PDB entry)

10. Peptidyl-prolyl cis-trans isomerase-like 2, Cyclophilin-60, PPI domain [141505] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141506] (1 PDB entry)

11. Peptidylprolyl isomerase domain and WD repeat-containing protein 1, PPWD1, C-terminal domain [141515] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141516] (1 PDB entry)

12. Putative cyclophilin PFE0505w [141513] (1 species)
    PPWD1 homologue

    • Species Plasmodium falciparum [TaxId:5833] [141514] (1 PDB entry)

More info for Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase)

Timeline for Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase):

• Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase) first appeared (with stable ids) in SCOP 1.55
  
• Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase) appears in SCOP 1.71
  
• Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase) appears in SCOP 1.75
  
• Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase) appears in the current release, SCOPe 2.08